Diagnostic Value of Serum Procalcitonin and C-reactive Protein for Infections after Allogeneic Hematopoietic Stem Cell Transplantation versus Nontransplant Setting
スポンサーリンク
概要
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Objective Procalcitonin (PCT) has been increasingly used as a biomarker of infection. The purpose of this study was to evaluate its diagnostic value after hematopoietic stem cell transplantation (HSCT), where non-infectious febrile complications such as graft-versus-host disease frequently develop. Methods We retrospectively analyzed 144 febrile episodes (infections: 82, and noninfections: 62) in adult patients with hematological disorders, including 57 and 87 episodes in HSCT and non-HSCT patients, respectively. Results Of 57 febrile episodes in HSCT patients, 46 (86%) and 25 (44%) revealed positivity for C-reactive protein (CRP) and PCT, respectively. Among 87 febrile episodes in non-HSCT patients, 81 (93%) and 22 (25%) events showed positive results of CRP and PCT. Both of these biomarkers were associated with infectious episodes in univariate analysis. Multivariate analysis showed that a high cut-off level (>9.5 mg/dL) of CRP was a better indicator for infections than PCT in HSCT patients, while PCT positivity was more diagnostic for infections than any cutoff CRP level in non-HSCT patients. Conclusion It may be necessary to interpret the results of these biomarkers with different orders of priority in transplant versus nontransplant patients.
著者
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Iwasaki Hiromi
Center For Cellular And Molecular Medicine Kyushu University Graduate School Of Medical Sciences
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Akashi Koichi
Department Of Medicine & Biosystemic Science Kyushu University
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Teshima Takanori
Center For Cellular And Molecular Medicine Kyushu University Hospital
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Harada Naoki
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Mori Yasuo
Department Of Chemistry Faculty Of Science Kyoto University
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Kato Koji
Department Of Applied Life Science Faculty Of Applied Biological Sciences Gifu University
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Miyamoto Toshihiro
Department Of Hematology Hamanomachi Hospital
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Takenaka Katsuto
Department Of Hematology Hamanomachi General Hospital
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Teshima Takanori
Center for Cellular and Molecular Medicine, Kyushu University, Japan
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Miyawaki Kohta
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Japan
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Akashi Koichi
Department of Hematology/Oncology, Kyushu University Hospital, Japan
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Iwasaki Hiromi
Center for Cellular and Molecular Medicine, Kyushu University, Japan
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Takenaka Katsuto
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Japan
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Akashi Koichi
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Japan
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