＜Syposium II＞Inactivation of voltage-gated Ca^2+ channels and cone-rod dystrophy CORD7
スポンサーリンク
概要
- 論文の詳細を見る
Active zones are highly specialized sites for release of neurotransmitter in presynaptic nerve terminals.The spacing between voltage-dependent calcium channels（ VDCCs） and synaptic vesicles at active zones is thoughtto infl uence the dynamic properties of synaptic transmission. Recently we have demonstrated a novel molecularinteraction between VDCCs and an active zone scaffolding protein, rab3-interacting molecule 1 （RIM1）. TheRIM1 induced a pronounced deceleration of inactivation rate and a depolarizing shift of the inactivation curve ofrecombinant P/Q-type VDCC expressed as α1Aα2/δβ1a complex in baby hamster kidney cells. During 2-s voltagedisplacementto -30 mV, which is the threshold of the P/Q-type VDCC activation, almost all channels were inactivatedin the absence of the RIM1 （closed-state inactivation）, but less than 20% of the channels were inactivated inthe presence of the RIM1. Thus, the RIM1 coordinates calcium signaling and spatial organization of molecularconstituents at presynaptic active zone. A mutation has been identified for an autosomal dominant cone-rod dystrophy CORD7 in the RIM1 gene.Interestingly, the aff ected individuals showed signifi cantly enhanced cognitive abilities across a range of domains. Themouse RIM1 arginine-to-histidine substitution （R655H）, which corresponds to the human CORD7 mutation, modifi esRIM1 function in regulating VDCC currents elicited by the P/Q-type Cav2.1 and L-type Cav1.4 channels. The datacan raise an interesting possibility that CORD7 phenotypes including retinal defi cits and enhanced cognition are atleast partly due to altered regulation of presynaptic VDCC currents.
著者
-
Wakamori Minoru
Department of Oral Biology, Tohoku University Graduate School of Dentistry
-
Uriu Yoshitsugu
Department of Synthetic Chemistry and Biological Chemistry, Kyoto University Graduate School of Engi
-
Miki Takafumi
Department of Synthetic Chemistry and Biological Chemistry, Kyoto University Graduate School of Engi
-
Kiyonaka Shigeki
Department of Synthetic Chemistry and Biological Chemistry, Kyoto University Graduate School of Engi
-
Mori Yasuo
Department of Synthetic Chemistry and Biological Chemistry, Kyoto University Graduate School of Engi
-
Miki Takafumi
Department Of Synthetic Chemistry And Biological Chemistry Kyoto University Graduate School Of Engin
-
Mori Yasuo
Department Of Synthetic Chemistry And Biological Chemistry Graduate School Of Engineering Kyoto Univ
-
Uriu Yoshitsugu
Department Of Synthetic Chemistry And Biological Chemistry Kyoto University Graduate School Of Engin
-
Wakamori Minoru
Department Of Oral Biology Tohoku University Graduate School Of Dentistry
-
Kiyonaka Shigeki
Department Of Chemistry And Biochemistry Graduate School Of Engineering Kyushu University
-
Kiyonaka Shigeki
Department Of Synthetic Chemistry And Biological Chemistry Kyoto University Graduate School Of Engin
-
Mori Yasuo
Department Of Synthetic Chemistry And Biological Chemistry Kyoto University Graduate School Of Engin
-
Mori Yasuo
Department Of Chemistry Faculty Of Science Kyoto University
関連論文
- ＜Syposium II＞Inactivation of voltage-gated Ca^2+ channels and cone-rod dystrophy CORD7
- DPE-007 Protein Kinase G-mediated Inhibition of TRPC6 Channel Activity Participates in Anti-hypertrophic Effect of Cardiac Natriuretic Peptides(DPE02,Heart Failure, Basic (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japan
- 3P-005 四量体Orai1分子は細長い細胞質ドメインを持つ水滴形構造である(蛋白質-構造,第47回日本生物物理学会年会)
- Second unrelated cord blood transplantation using a reduced-intensity conditioning regimen combined with gemtuzumab ozogamicin in patients with relapsed acute myelogenous leukemia
- 1P-009 透過型電子顕微鏡を用いた三次元再構成法によって明らかにされた、TRPM2陽イオンチャネルの膨れたベル形構造(蛋白質・構造(1),第46回日本生物物理学会年会)
- 1P-001 単粒子解析によるTRP family内でのchannelの構造比較(蛋白質・構造(1),第46回日本生物物理学会年会)
- Point-Mutations Related to the Loss of Batrachotoxin Binding Abolish the Grayanotoxin Effect in Na^+ Channel Isoforms
- Facile Preparation of Robust Organic Gels by Cross - link of a Sugar - integrated Gelator by Toluene - 2, 4 - diisocyanate
- The Synthesis of a Reconstituted C_-Modified Protein
- A Study on Flow Characteristics and Heat Transfer in Countercurrent Water and Air Flows
- Mapping of Non-methylated and Methylated Restriction Sites in the Promoter Region of the Maize Gene for Phosphoenolpyruvate Carboxylase Involved in C_4 Photosynthesis(Biological Chemistry)
- FEASIBILITY OF UROKINASE IN THE TREATMENT OF ACUTE MYOCARDIAL INFARCTION
- Pd(en) as a Sequence-Selective Molecular Pinch for α-Helical Peptides
- Subunit dissociation of TRPC3 ion channel under high-salt condition
- Study on Forced Convective Heat Transfer in Curved Pipes : 1st Report, Laminer Region (the Journal and the Transactions of the Japan Society of Mechanical Engineers)
- Diagnostic Value of Serum Procalcitonin and C-reactive Protein for Infections after Allogeneic Hematopoietic Stem Cell Transplantation versus Nontransplant Setting
- Neuronal Ca^-sensitive Non-selective Cation Channels and TRPC5
- Initial low-dose valganciclovir as a preemptive therapy is effective for cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients
- Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma