Chemical Structure of Antithrombin-active Rhamnan Sulfate from Monostrom nitidum
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概要
- 論文の詳細を見る
Rhamnan sulfate was extracted with boiling water from the cell wall of Monostroma nitidum, and the resulting extract was purified by ion-exchange and size-exclusion chromatography. The polysaccharide, which is regarded as a homopolysaccharide, was 6-fold more antithrombin-active than the heparin standard. The antithrombin activity was decreased, by desulfation, although the non-active product still retained 8% of the sulfate ester. A comparative structural study of the intact rhamnan sulfate and rhamnan, its desulfated product, by periodate oxidation, Smith degradation and methylation analysis revealed the rhamnan sulfate to consist of α-1,3-linked L-rhamnose residues, some of which were substituted with sulfate groups mainly at position O-2. Minor amounts of internal 1,2-linked rhamnose and branched rhamnose linkages were also detected.
- 社団法人日本農芸化学会の論文
- 1998-09-23
著者
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Harada Naoki
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Harada N
Nihon Univ. Fujisawa Jpn
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MAEDA Masaakira
Department of Biochemistry, Saitama University
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Maeda Masaakira
Department Of Biochemistry Faculty Of Science Saitama University
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Maeda Masaakira
Department Of Biochemistry Saitama University
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Hakada Naoki
Department of Biochemistry, Saitama University:(Present address)Chugai Pharmaceutical Co. Ltd.
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