Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA – Benzodiazepine Receptor Complex
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概要
- 論文の詳細を見る
In the present study, we investigated the effect of the Kampo medicine Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300 mg/kg, p.o.) prolonged the pentobarbital-induced sleeping time in socially isolated mice without affecting pentobarbital sleep in group-housed mice. The prolongation of sleeping time by YKS was reversed by bicuculline (3 mg/kg, i.p.) and flumazenil (3 mg/kg, i.p.), but not WAY100635. These findings suggest that the GABAA – benzodiazepine receptor complex, but not 5-HT1A receptors, is involved in the reversal effect of YKS on the decrease of pentobarbital sleep by social isolation.
著者
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Uchida Naoki
Department of Psychiatry, Fukuoka University School of Medicine
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Oishi Ryozo
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Iwasaki Katsunori
Dep. Of Neuropharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ.
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Nishimura Ryoji
Department Of Psychiatry Faculty Of Medicine Fukuoka University
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江頭 伸昭
福岡大学薬学部応用薬理学教室
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Egashira Nobuaki
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Iwasaki Katsunori
Department Of Mathematical Sciences The University Of Tokyo
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Nogami Ai
Department Of Neuropharmacology Fukuoka University
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Takasaki Kotaro
Department Of Neuropharmacology Fukuoka University
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Ishibashi Ayumi
Department Of Chemistry And Biochemistry Graduate School Of Engineering Kyushu University
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Mishima Kenichi
Department Of Chemical Engineering Faculty Of Engineering Fukuoka University
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Iwasaki Katunori
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Fujiwara Michihiro
Department Of Neuroparmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Uchida Naoki
Department Of Psychiatry Fukuoka University School Of Medicine Fukuoka University
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Takasaki Kotaro
Department Of Neuropharmacology Faculty Of Pharmaceutical Science Fukuoka University
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Nogami Ai
Department Of Neuropharmacology Faculty Of Pharmaceutical Science Fukuoka University
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