The Pharmacological Characterization of Attentional Processes Using a Two-lever Choice Reaction Time Task in Rats

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概要

• 論文の詳細を見る

• Activating the noradrenergic and cholinergic systems is known to enhance attentional processes, while stimulating dopaminergic, serotonergic, and GABAergic systems suppresses them. The objective of the present study was to investigate the pharmacological characterization in the attentional processes of a two-lever choice reaction time (CRT) task using different centrally acting drugs. We designed seven parameters in this task: the correct response (CR) rate; error response rate; nonresponse (NR) rate; differential reinforcement of other behavior (DRO) responses; number of incorrect lever pressings during both the intertrial interval and DRO periods; the mean CRT of CR; and activity during 30 trials. The compounds produced different profiles at each dose. 1) Facilitative and disruptive effects on attentional processes occurred with changes in CRT alone. Scopolamine (0.1 mg/kg) and prazosin (0.3—1 mg/kg) prolonged the CRT, whereas methamphetamine (0.3 mg/kg) shortened the CRT. 2) Attentional deficits occurred with abnormal behavior showing premature response or perseverative behavior. Scopolamine (0.2—1 mg/kg), methamphetamine (3 mg/kg), Δ9-tetrahydrocannabinol (10 mg/kg), and MK-801 (0.1—0.3 mg/kg) produced a marked increase in the number of total lever pressings. 3) Motor function deficits rather than attentional deficits occurred. 8-OH DPAT (1 mg/kg) and muscimol (1 mg/kg) produced a decrease in CR and an increase in NR with a marked decrease in activity and prolonged the CRT. Activating noradrenergic α1 receptors was found to enhance the attentional processes, while blocking muscarinic receptors, α1 receptors, and NMDA receptors, and stimulating cannabinoid receptors and the dopaminergic systems impaired the attentional processes in the two-lever CRT task.

• 2002-12-01

著者

• 藤原 道弘

  福岡大学薬学部薬学科

• Egashira Nobuaki

  Department of Pharmacy, Kyushu University Hospital

• Mishima Kenichi

  Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Fujiwara Michihiro

  Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• IWASAKI Katsunori

  Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• 藤原 道弘

  福岡大・薬・応用薬理

• 藤原 道弘

  福岡大学応用薬理

• 藤原 道弘

  福岡大学 薬学部 応用薬理学教室

• 藤原 道弘

  九州大学薬学部

• Iwasaki Katsunori

  Dep. Of Neuropharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ.

• Shoyama Yukihiro

  Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyushu University

• HONDA Yoko

  Department of Biochemistry, Physiology, and Medicine, Loma Linda University, Pettis Veterans Affairs

• FUJII Megumi

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Mishima Kenichi

  Dep. Of Neuropharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ.

• Egashira Nobuaki

  Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Yoshikawa Tetsuya

  Department Of Neuroparmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Yoshikawa Tetsuya

  Department Of Mechanical Engineering Kyoto University

• Iwasaki Katsunori

  Department Of Mathematical Sciences The University Of Tokyo

• Honda Yoko

  Department Of Neuroparmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Fujii Megumi

  Department Of Neuroparmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Mishima Kenichi

  Department Of Chemical Engineering Faculty Of Engineering Fukuoka University

• Iwasaki Katunori

  Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• AOO Naoya

  Department of Neuroparmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• FUKUE Yoshihiko

  Department of Neuroparmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• 藤原 道弘

  Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Fujiwara Michihiro

  Department Of Neuroparmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Shoyama Yukihiro

  Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyushu University

• Aoo Naoya

  Department Of Neuroparmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Fukue Yoshihiko

  Department Of Neuroparmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Shoyama Yukihiro

  Department Of Medicinal Resources Regulation Graduate School Of Pharmaceutical Sciences Kyushu Unive

• Shoyama Yukihiro

  Department Of Forestry Faculty Of Agriculture Kyushu University

• Honda Yoko

  Department Of Biochemistry Physiology And Medicine Loma Linda University Pettis Veterans Affairs Hos

• SHOYAMA Yukihiro

  Department of Chemo-Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kyushu University

• Yoshikawa Tetsuya

  Department of Electrical Engineering and Information Systems The University of Tokyo

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