マウスのオキソトレモリン誘発振戦に及ぼすモノアミン関連薬物の影響

概要

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It is an important way to elucidating whether the drug has central cholinergic effects, especially, when the new drug is developed as a psychotropic drug. For example, cholinergic agonists are often useful for dementia while cholinergic antagonists for Parkinson's disease. Oxotremorine, one of the most typical cholinergic agonist which acts directly to the muscarinic receptor in the brain, induce whole body tremor in mine. In the present study, we investigated the central cholinergic activity of various drugs using oxotremorine-induced-tremor in mice. The low dose of oxotremorine (0.3mg/kg, i.p.) caused slight tremor in mice, while the coadministrations with physostigmine, L-threo-DOPS and 5-HTP were significantly potentiated the tremor. It means that not only cholinergic drugs but also adrenergic and/or serotonergic drugs have central cholinergic potentiation. There results suggest that testing the potentiative effect of the oxotremorine-induced tremor of the drug is an easy and useful method for the first choice of evaluating new new nootropic drug.
九州女子大学・九州女子短期大学の論文