Delta(9)-tetrahydrocannabinol Enhances an Increase of Plasma Corticosterone Levels Induced by Forced Swim-Stress

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概要

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• The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB1 receptor antagonist O-2050 significantly reduced the enhancement of immobility by THC. We investigated the effect of THC on levels of stress hormone corticosterone under non-stress and forced swim-stress conditions. THC did not affect plasma corticosterone levels under non-stress conditions. However, THC, together with forced swim-stress, significantly increased plasma corticosterone levels. This effect was inhibited by O-2050. This evidence suggests that THC, under stressful conditions, enhances the susceptibility of the hypothalamus-pituitary-adrenal-axis to stress via the CB1 receptor, thereby increasing the risk of depression.

著者

• Egashira Nobuaki

  Department of Pharmacy, Kyushu University Hospital

• Oishi Ryozo

  Department of Pharmacy, Kyushu University Hospital

• Nagai Hiroshi

  Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Me

• TSUCHIHASHI Ryota

  Faculty of Pharmaceutical Sciences, Fukuoka University

• KINJO Junei

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Kinjo Junei

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Tsuchihashi Ryota

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Higuchi Sei

  Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

• Sano Kazunori

  Advanced Materials Institute, Fukuoka University

• Koushi Emi

  Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Irie Keiichi

  Advanced Materials Institute, Fukuoka University

• Uchida Naoki

  Department of Psychiatry, Fukuoka University School of Medicine

• Nishimura Ryoji

  Department of Psychiatry, Fukuoka University School of Medicine

• Tanaka Hiroyuki

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Morimoto Satoshi

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Mishima Kenichi

  Advanced Materials Institute, Fukuoka University

• Iwasaki Katsunori

  Advanced Materials Institute, Fukuoka University

• Fujiwara Michihiro

  Advanced Materials Institute, Fukuoka University

• Oishi Ryozo

  Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University

• Iwasaki Katsunori

  Dep. Of Neuropharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ.

• Nagai Hiroshi

  Department Of Cardiology Regeneratiion Medicine And Bioethics Gifu University Graduate School Of Med

• Nishimura Ryoji

  Department Of Psychiatry Faculty Of Medicine Fukuoka University

• Egashira Nobuaki

  Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Iwasaki Katunori

  Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Higuchi Sei

  Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Nagai Hiroshi

  Department Of Anatomy Okayama University Sohool Of Dentistry

• Tanaka Hiroyuki

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Nagai Hiroshi

  Department Of Anatomy Okayama University School Of Dentistry

• Uchida Naoki

  Department Of Psychiatry Fukuoka University School Of Medicine Fukuoka University

• Morimoto Satoshi

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Nagai Hiroshi

  Department of Psychiatry, Fukuoka University School of Medicine

• UCHIDA Naoki

  Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University

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