Clinical and Experimental Evidence for Prevention of Acute Renal Failure Induced by Radiographic Contrast Media
スポンサーリンク
概要
- 論文の詳細を見る
Acute renal failure still occurs as a complication after radiographic examination using iodinated radiocontrast medium. The incidence rate of radiocontrast medium-induced nephropathy (radiocontrast nephropathy) is low (2 – 3%) in general. However, the rate is remarkably elevated in patients with pre-existing renal insufficiency. Radiocontrast nephropathy is associated with increased morbidity and mortality, particularly in patients with percutaneous coronary interventions. Although the reduction in renal blood flow and direct toxic action on renal tubular cells are considered to be involved, little is known about the etiology of radiocontrast nephropathy. A number of agents that improve renal circulation have been clinically tested for prevention of radiocontrast nephropathy, but none of them has succeeded. Protection of renal tubular cells against oxidative stress is another approach to avoid radiocontrast nephropathy. Prophylactic effects of antioxidants such as N-acetylcysteine and ascorbic acid have been reported by several investigators, although the effectiveness of these compounds is still a matter of debate. At present, hydration is regarded as the only effective, though incomplete, prophylactic regimen for radiocontrast nephropathy. Recently, we have shown that caspase-dependent apoptosis is an important factor in the pathogenesis of radiocontrast nephropathy and clarified cellular mechanisms underlying the radiocontrast media-induced apoptosis. This review summarizes clinical and experimental evidence for the etiology and prevention of radiocontrast nephropathy.
- 社団法人 日本薬理学会の論文
- 2005-04-20
著者
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Oishi Ryozo
Department of Pharmacy, Kyushu University Hospital
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Sendo Toshiaki
Dep. Of Hospital Pharmacy Okayama Univ. Medical School Jpn
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Sendo Toshiaki
岡山大学 医歯薬学総合研究科薬理学
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Sendo Toshiaki
Department Of Hospital Pharmacy Okayama University Medical And Dental School
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Sendoh Toshiaki
九州大学 薬
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Sendo T
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Sendo Toshiaki
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Oishi R
Dep. Of Pharmacy Kyushu Univ. Hospital Jpn
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Oishi Ryozo
Department Of Pharmacy Kyushu University Hospital
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Oishi Ryozo
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Itoh Yoshinori
Department of Cardiovascular Medicine, Hokkaido University, Graduate School of Medicine
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Itoh Yoshinori
九州大学病院 薬剤部
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Itoh Yoshinori
Department Of Cardiovascular Medicine Hokkaidou University Graduate School Of Medicine
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YANO Takahisa
Department of Pharmacy, Kyushu University Hospital
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Yano Takahisa
Dep. Of Pharmacy Kyushu Univ. Hospital Jpn
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Yamada Takaaki
Department Of Pharmacy Kyushu University Hospital
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Yano Takahisa
Department Of Pharmacy Kyushu University Hospital
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Itoh Yoshinori
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Itoh Yoshinori
Department Of Cardiorenal And Cerebrovascular Medicine Kagawa University
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Yano Takahisa
Department Of Nano Material And Bio Engineering Graduate School Of Engineering At Tokusihima Bunri University
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Sendo Toshiaki
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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