The Evaluation of Risk Factors Associated with Adverse Drug Reactions by Metformin in Type 2 Diabetes Mellitus
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概要
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Metformin is a drug to improve glycemic control by reducing insulin resistance and is currently considered to be one of the first-choice drugs for type 2 diabetes mellitus (T2DM). However, during metformin use, adverse drug reactions (ADRs) including gastrointestinal adverse events were frequently observed. Thus, in the present study, we investigated the incidence of ADRs induced by metformin and further analyzed risk factors for ADRs in Japanese patients with type 2 diabetes mellitus who initially administered metformin (500–750 mg). One hundred and one hospitalized patients receiving metformin during September 1, 2009 and August 31, 2010 were studied. The incidence of ADRs and changes in laboratory data including hemoglobin A1c (HbA1c) were monitored retrospectively. The anti-glycemic effect of metformin was successfully observed as indicated by decreased HbA1c. Among ADRs, diarrhea was most frequently occurred during metformin use (26.7% of patients) although the symptom of diarrhea was mild in most cases and disappeared within 3 d after the initial use. A logistic regression analysis showed the existence of six risk factors, including initial dose (750 mg), female, age (≦65), body mass index (≧25), aspartate aminotransferase (≧30 IU/L) and alkaline phosphatase (≧270 IU/L). The incidence of diarrhea increased linearly as the number of risk factors increased. In conclusion, in order to avoid ADRs, especially diarrhea, subsequently improving the quality of life during metformin use, the optimization of the dose of metformin by considering risk factors would be beneficial for patients with T2DM.
著者
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Horikawa Yukio
Department Of Diabetes And Endocrinology Division Of Molecule And Structure Gifu University School O
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Kitaichi Kiyoyuki
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Takeda Jun
Department Of Biological Sciences Graduate School Of Science Tokyo Metropolitan University
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Itoh Yoshinori
Department Of Cardiorenal And Cerebrovascular Medicine Kagawa University
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Suwa Tetsuya
Department Of Diabetes And Endocrinology Graduate School Of Medicine Gifu University
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Kitaichi Kiyoyuki
Department of Pharmacy, Gifu University Hospital
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Okayasu Shinji
Department of Pharmacy, Gifu University Hospital
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Hori Akina
Department of Pharmacy, Gifu University Hospital
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Yamamoto Mayumi
United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University
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Itoh Yoshinori
Department of Pharmacy, Gifu University Hospital
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Horikawa Yukio
Department of Diabetes and Endocrinology, Division of Molecule and Structure, School of Medicine, Gifu University
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Suwa Tetsuya
Department of Diabetes and Endocrinology, Division of Molecule and Structure, School of Medicine, Gifu University
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Takeda Jun
Department of Diabetes and Endocrinology, Division of Molecule and Structure, School of Medicine, Gifu University
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Horikawa Yukio
Department of Applied Chemistry, Faculty of Engineering, Osaka University
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