Effect of Diazepam on the Runway Method Using Priming Stimulation of Intracranial Self Stimulation Behavior
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概要
- 論文の詳細を見る
Intracranial self-stimulation (ICSS) behavior is an experimental methodology to study reward and motivational effects. We have established a paradigm to evaluate enhancing motivation by drugs in the runway method using the priming stimulation of ICSS. In the present study, we investigated the effects of diazepam on the experimental extinction process of non-reinforcing reward and pre-trial electric priming stimulations in lateral hypothalamic self-stimulation. The extinction process in the runway method consisted of these 15 trials. Diazepam, an anti-anxiety drug, at doses of 0.5 and 1 mg/kg (i.p.) delayed the extinction of running behavior when priming stimulation was given. The GABAergic antagonist flumazenil at doses of 5 and 10 mg/kg (i.p.) totally prevented the effect of diazepam. These results demonstrate that diazepam delays the extinction of running behavior on ICSS in the runway method and flumazenil, a GABAergic antagonist, eliminates the delayed effect of diazepam, that is, indicating that the delayed extinction effect of diazepam may be related to facillitation of motivation, which was promoted via the GABAergic system in the ICSS behavior.
- 社団法人 日本薬理学会の論文
- 2008-07-20
著者
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Sendo Toshiaki
Dep. Of Hospital Pharmacy Okayama Univ. Medical School Jpn
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Sendo Toshiaki
Department Of Hospital Pharmacy Okayama University Medical And Dental School
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Sagara Hidenori
Department Of Hospital Pharmacy Okayama University Medical School
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Sagara Hidenori
岡山大学 大学院医歯薬学総合研究科医薬管理学
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Sagara Hidenori
松山大学 医薬情報解析学
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Sagara Hidenori
岡山大学医学部附属病院 薬剤部
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Sagara Hidenori
岡山大学病院 薬剤部
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Sagara Hidenori
岡山大学 臨床薬剤学分野
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Gomita Yutaka
Dep. Of Hospital Pharmacy Okayama Univ. Medical School Jpn
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Gomita Yutaka
岡山大学 医歯薬学総合研究科医薬管理学
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Gomita Y
Okayama Univ. Medical School Okayama Jpn
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ARAKI Hiroaki
Division of Pharmacy, Ehime University Hospital
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Gomita Y
Shujitsu Univ. School Of Pharmacy Okayama Jpn
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Araki H
Division Of Pharmacy Ehime University Hospital
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Araki Hiroaki
愛媛大学医学部附属病院 薬剤部
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Araki Hiroaki
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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Araki Hiroaki
Ehime Univ. Graduate School Of Medicine Ehime Jpn
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KITAMURA Yoshihisa
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Sendo T
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Sendo Toshiaki
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Gomita Yutaka
Department Of Hospital Pharmacy
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Gomita Yutaka
吉備国際大学 保健科学部作業療法学科
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Gomita Yutaka
科研製薬総合研究所
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Araki H
Dep. Of Clinical Pharmacology And Pharmacy Brain Sci. Ehime Univ. Graduate School Of Medicine Jpn
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Araki Hiroaki
Division Of Pharmacy Ehime University Hospital
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Gomita Y
Daiichi Coll. Pharmaceutical Sciences Fukuoka Jpn
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Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
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Kitamura Yoshihisa
Department Of Pharmaceutical Care And Health Science Graduate School Of Medicine Dentistry And Pharm
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Kawasaki Yoichi
Department Of Pharmacy Okayama University Hospital
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Kitamura Yoshihisa
Department Of Pharmaceutical Care And Health Science Graduate School Of Medicine Dentistry And Pharm
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Araki Hiroaki
Division of Hospital Pharmacy, Ehime University Hospital
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Sendo Toshiaki
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
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KITAMURA Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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