Inhibitory Effect of Olopatadine on Antigen-Induced Eosinophil Infiltration and the LFA-1 and Mac-1 Expression in Eosinophils
スポンサーリンク
概要
- 論文の詳細を見る
The inhibitory effect of olopatadine, a new antiallergic drug, on antigen-induced eosinophil infiltration and its mechanisms were examined using the local sensitized rat allergic rhinitis model and isolated IL-5-stimulated rat peritoneal eosinophils. Olopatadine dose-dependently inhibited antigen-induced eosinophil infiltration in the nasal mucosa. Olopatadine dose-dependently repressed the IL-5-induced expressions of CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) on rat peritoneal eosinophils. However, olopatadine had no effect on IL-5-induced CD49d/CD29 (VLA-4) expression. These results suggest that olopatadine may inhibit antigen-induced eosinophil infiltration through repression of LFA-1 and Mac-1 expression.
- 社団法人 日本薬理学会の論文
- 2002-04-01
著者
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Sagara Hidenori
Department Of Hospital Pharmacy Okayama University Medical School
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Sagara Hidenori
徳島文理大学 薬 薬理
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Sagara Hidenori
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Akagi Masaaki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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MATSUI Nobuaki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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FUKUISHI Nobuyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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MATSUHISA Motoko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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SHIMONO Takeshi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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MURATA Nobutoshi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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IWANAGA Mari
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Iwanaga Mari
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Akagi Masaaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Matsui Nobuaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Shimono Takeshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Matsui Nobuaki
Department Of Gastroenterological And General Surgery Showa University School Of Medicine
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Matsuhisa Motoko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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