INHIBITON OF NF-κB ACTIVATION DURING ISCHEMIA REDUCES HEPATIC ISCHEMIA/REPERFUSION INJURY IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The aim of this study was to determine whether nuclear factor-κB (NF-κB) inhibitors are efficient against hepatic ischemia/reperfusion (I/R) injury. We previously demonstrated that xanthine oxidase-derived reactive oxygen species activate NF-κB during ischemia. However, the role of NF-κB activation during ischemia in post-reperfusion injury remains unclear. Therefore, while we examined the effects of NF-κB inhibitors, sulfasalazine and pyrrolidinedithiocarbamate on hepatic I/R injury using a rat lobar hepatic I/R model, we estimated the relationship between NF-κB activation during ischemia and following hepatic damage caused by reperfusion. The portal vein and the hepatic artery were clamped for 1 hr followed by reperfusion for up to 24 hr. NF-κB activation was determined by Western blot analysis. NF-κB activation was observed in the ischemic lobe of the liver, and the activation was prevented by preadministration with NF-κB inhibitors. Although the serum ALT level, hepatic MPO activity and BSP clearance, as an index of hepatic injury, were increased after reperfusion, the increase was attenuated by pre-administration with NF-κB inhibitors. These findings suggest that NF-κB activation during ischemia is relevant to hepatic I/R injury. Moreover, we first showed that pre-administration with NF-κB inhibitors is effective against hepatic I/R injury.
- 日本トキシコロジー学会の論文
- 2005-05-25
著者
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YASUI Yumiko
Department of Oncologic Pathology, Kanazawa Medical University
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Nagata Tomomi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Akagi Masaaki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Yasui Yumiko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Yasui Yumiko
Department Of Oncologic Pathology Kanazawa Medical University
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MATSUI Nobuaki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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FUKUISHI Nobuyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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KASAJIMA Kazumi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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HADA Masazumi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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SENGA Nobuko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Senga Nobuko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Hada Masazumi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Akagi Masaaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Matsui Nobuaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Kadota Kazue
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.
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Matsui Nobuaki
Department Of Gastroenterological And General Surgery Showa University School Of Medicine
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Kasajima Kazumi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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