Intracerebroventricular Injection of Microglia Protects Against Focal Brain Ischemia

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概要

• 論文の詳細を見る

• Microglia are macrophage-like phagocytic cells in the brain parenchyma. However, microglial function after neurodegeneration is not fully understood. In this study, occlusion of the middle cerebral artery (MCA) and reperfusion caused massive neuronal loss in the rat cerebral cortex and striatum after 3 days. When exogenous microglia were microinjected into the intracerebroventricle during MCA occlusion, neurodegenerative areas significantly decreased. At that time, migrated microglia were detected in the ischemic lesion. These results suggest that exogenous microglia can migrate into brain parenchyma and then protect against neurodegeneration induced by MCA occlusion and reperfusion.

• 社団法人 日本薬理学会の論文
• 2004-02-01

著者

• Takata Kazuyuki

  Faculty Of Pharmaceutical Sciences Hoshi University

• Taniguchi Takashi

  Department of Geophysics, Faculty of Science, Hokkaido University

• Taniguchi T

  Department Of Neurobiology Kyoto Pharmaceutical University

• Takahashi Kazunori

  京都薬科大学 病態生理学

• Taniguchi Takashi

  京都薬科大学 病態生理学

• KITAMURA Yoshihisa

  Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Yanagisawa Daijiro

  Department Of Neurobiology Kyoto Pharmaceutical University

• INDEN Masatoshi

  Department of Neurobiology, Kyoto Pharmaceutical University

• TAKATA Kazuyuki

  Department of Neurobiology, Kyoto Pharmaceutical University

• TSUCHIYA Daiju

  Department of Neurobiology, Kyoto Pharmaceutical University

• Tsuchiya Daiju

  Department Of Neurobiology 21st Century Coe Program Kyoto Pharmaceutical University

• Takata Kazuyuki

  Department Of Mechanical Engineering Aichi Institute Of Technology

• Inden Masatoshi

  Department Of Neurobiology And 21st Century Coe Program Kyoto Pharmaceutical University

• NAKATA Junko

  Department of Neurobiology, Kyoto Pharmaceutical University

• Takeuchi Kosei

  Kan Research Institute Inc. Kobe Mi R&d Center

• Takenawa Tadaomi

  Division Of Biochemistry Institute Of Medical Science University Of Tokyo

• Kanai Yoshihito

  Department Of Pharmaceutical Care And Health Sciences Okayama University Graduate School Of Medicine

• Kitamura Yoshihisa

  Department Of Neurobiology Kyoto Pharmaceutical University

• Kitamura Yoshihisa

  Department Of Pharmacology Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical Unive

• Kitamura Y

  Department Of Neurobiology Kyoto Pharmaceutical University

• Kitamura Y

  Shimizu Pharmaceutical Co. Ltd. Shizuoka Jpn

• Nakata Junko

  Department Of Neurobiology Kyoto Pharmaceutical University

• Nakata Junko

  Department Of Bioproduction Science Faculty Of Horticulture Chiba University

• Taira Takahiro

  Graduate School Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology Co

• Takano T

  Dep. Of Neurobiology Kyoto Pharmaceutical Univ.

• Taniguchi Takashi

  Department Of Geophysics Faculty Of Science Hokkaido University

• Taniguchi Takashi

  Department Of Dermatology Faculty Of Medicine University Of Tokyo

• Inden Masatoshi

  Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University

• Takata Kazuyuki

  Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University

• TANIGUCHI Takashi

  Department of Computational Science and Engineering, Nagoya University

• Kitamura Yoshihisa

  Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan

• Taniguchi Takashi

  Department of Biology, Kyoto Pharmaceutical University

• KITAMURA Yoshihisa

  Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University

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