R-(−)-α-Methylhistamine, a Histamine H3 Receptor Agonist, Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries
スポンサーリンク
概要
- 論文の詳細を見る
A novel histamine receptor subtype, histamine H3 receptor, mediates inhibition of peripheral autonomic neurotransmission. The present study was designed to examine vascular effects of histamine H3 receptor by using a selective histamine H3 receptor agonist, R-(−)-α methylhistamine (α-methylhistamine), in rat mesenteric resistance arteries. The isolated mesenteric vascular beds were perfused with Krebs solution and perfusion pressure was measured. Active tone was produced by perfusion of Krebs solution containing 7 μM methoxamine. In preparations with intact endothelium, perfusion of α-methylhistamine (1—100 μM) for 1 min produced a concentration-dependent vasodilation. The maximum vasodilation at the highest concentration was approximately 45%. This vasodilation was abolished by endothelium removal and attenuated by histamine H3 receptor antagonists, thioperamide and clobenpropit, but not by chlorpheniramine (histamine H1 receptor antagonist) and cimetidine (histamine H2 receptor antagonist). Nω-nitro-L-arginine methyl ester (L-NAME, nitric oxide (NO) synthase inhibitor), indomethacin (cyclooxygenase inhibitor) and tetraethylammonium (nonselective K+-channel blocker) and high KCl (30 mM) significantly inhibited α-methylhistamine-induced endothelium-dependent vasodilation. These findings suggest that α-methylhistamine induces endothelium-dependent vasodilation mainly via endothelium histamine H3 receptors. It is also suggested that activation of histamine H3 receptors in the endothelium releases mainly NO and partially prostaglandin I2 and endothelium-derived hyperpolarizing factors to induce endothelium-dependent vasodilation.
著者
-
Jin Xin
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
-
Jin Xin
Department Of Applied Chemistry Harbin Institute Of Technology
-
Koyama Toshihiro
Department Of Applied Chemistry Faculty Of Engineering Hiroshima University
-
Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
-
Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
-
Li Simin
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
-
SUN Pengyuan
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
-
Jin Xin
Department of Clinical Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
-
Sun Pengyuan
Department of Clinical Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
-
Koyama Toshihiro
Department of Clinical Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
-
Kawasaki Hiromu
Department of Clinical Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
-
Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
関連論文
- Identification of a Novel Planarian G-Protein-Coupled Receptor That Responds to Serotonin in Xenopus laevis Oocytes
- Oxidative Neurodegeneration Is Prevented by UCP0045037, an Allosteric Modulator for the Reduced Form of DJ-1, a Wild-Type of Familial Parkinson's Disease-Linked PARK7
- Royal Jelly Ameliorates Insulin Resistance in Fructose-Drinking Rats(Pharmacognosy)
- Neuroprotective Effects of Quercetin and Rutin on Spatial Memory Impairment in an 8-Arm Radial Maze Task and Neuronal Death Induced by Repeated Cerebral Ischemia in Rats
- Nicotinic Acetylcholine α4β2 Receptor Regulates the Motivational Effect of Intracranial Self Stimulation Behavior in the Runway Method
- Parkinsonian Rotenone Mouse Model: Reevaluation of Long-Term Administration of Rotenone in C57BL/6 Mice
- Effect of Aripiprazole on 5-HT_2 Receptor-mediated Wet-Dog Shake Responses and Disruption of Prepulse Inhibition in Rats
- An Approach to Predict the Ductus-Arteriosus Dilating Effect Induced by Lipo-Prostaglandin E_1 in Newborn Rats Lacking Plasma Concentration-Time Data by the Pharmacological Response Kinetic Model
- Chronic Treatment with Imipramine and Lithium Increases Cell Proliferation in the Hippocampus in Adrenocorticotropic Hormone-Treated Rats
- Effect of Methamphetamine and Imipramine on Cerebral Ischemia-Induced Hyperactivity in Mongolian Gerbils
- Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson's Disease-Linked PARK7
- Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7
- Massive Epistaxis From a Thrombosed Intracavernous Internal Carotid Artery Aneurysm 2 Years After the Initial Diagnosis : Case Report
- Counseling of Patients with Bronchial Asthma, and Clinical Pharmacy Practice and Education of Pharmacy School Students
- Proteasome Inhibitors Protect Against Degeneration of Nigral Dopaminergic Neurons in Hemiparkinsonian Rats
- Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons
- Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-△^ Prostaglandin J_2-Sensitive Microglial Activation
- Studies on Somnolence in the Daytime Caused by Drugs Used for Neuropathic Pain
- The Parkinsonian Models : Invertebrates to Mammals
- Malfunction of Vascular Control in Lifestyle-Related Diseases : Distribution of Adrenomedullin-Containing Perivascular Nerves and Its Alteration in Hypertension
- Inhibitory Effects of Antiparkinsonian Drugs and Caspase Inhibitors in a Parkinsonian Flatworm Model
- Neurotrophic Effect of Hepatic Growth Factor (HGF) on Reinnervation of Perivascular Calcitonin Gene-Related Peptide (CGRP)-Containing Nerves Following Phenol-Induced Nerve Injury in the Rat Mesenteric Artery
- Effect of Diazepam on the Runway Method Using Priming Stimulation of Intracranial Self Stimulation Behavior
- The 5-HT_ Receptor Full Agonist, 8-OH-DPAT Inhibits ACTH-Induced 5-HT_ Receptor Hyperfunction in Rats : Involvement of 5-HT_ Receptors in the DOI-Induced Wet-Dog Shakes in ACTH-Treated Rats(Pharmacology)
- Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone-Treated Rats Are Not Affected by Chronic Imipramine Treatment : Possible Involvement of Enhanced 5-HT_-Receptor Expression in the Frontal Cortex
- Influence of Lactation on Plasma Phenobarbital Concentrations in Rats
- Simple and rapid analysis of lamotrigine, a novel antiepileptic, in human serum by high-performance liquid chromatography using a solid-phase extraction technique
- Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus
- Morphological Change by Overexpression of D385A Dominant Negative Presenilin 1 in Human Neuroblastoma SH-SY5Y Cells
- Possible Involvement of P2X_7 Receptor Activation in Microglial Neuroprotection against Focal Cerebral Ischemia in Rats(Pharmacology)
- Identification and distribution of tryptophan hydroxylase (TPH)-positive neurons in the planarian Dugesia japonica
- Distribution of DJ-1, Parkinson's Disease-Related Protein PARK7, and Its Alteration in 6-Hydroxydopamine-Treated Hemiparkinsonian Rat Brain
- Recovery of Focal Brain Ischemia-Induced Behavioral Dysfunction by Intracerebroventricular Injection of Microglia
- FUNCTIONAL ASSAY OF DOPAMINERGIC AND SEROTONINERGIC NEURONS IN PLANARIAN(Physiology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Intracerebroventricular Injection of Microglia Protects Against Focal Brain Ischemia
- Possible Involvement of Both Endoplasmic Reticulum -and Mitochondria-Dependent Pathways in Thapsigargin-Induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells
- Involvement of Wiskott-Albrich Syndrome Protein Family Verprolin- Homologous Protein (WAVEAa9 and Rac1 in the Phagocytosis of Amyloid-β(1-42) in Rat Microglia
- Apoptotic Cell Death in Neurons and Glial Cells : Implications for Alzheimer's Disease
- Possible Involvement of Rapamycin-Sensitive Pathway in Bcl-2 Expression in Human Neuroblastoma SH-SY5Y Cells
- Motivational Effect of Nomifensine in the Intracranial Self-Stimulation Behavior Using a Runway Method(Pharmacology)
- Selegilin Exerts Antidepressant-Like Effects During the Forced Swim Test in Adrenocorticotropic Hormone-Treated Rats
- Motivational Effects of Methamphetamine as Measured by the Runway Method Using Priming Stimulation of Intracranial Self-stimulation Behavior(Analytical Biochemistry)
- Effects of Imipramine and Bupropion on the Duration of Immobility of ACTH-Treated Rats in the Forced Swim Test : Involvement of the Expression of 5-HT_ Receptor mRNA(Pharmacology)
- Effects of Long-Term Treatment With Calcium Antagonists on Periarterial Nerve Function in the Mesenteric Artery of Spontaneously Hyupertensive Rats
- Long-Term Treatment With Angiotensin Converting Enzyme Inhibitor Restores Reduced Calcitonin Gene-Related Peptide-Containing Vasodilator Nerve Function in Mesenteric Artery of Spontaneously Hypertensive Rats
- CHANGES IN CIRCADIAN RHYTHM OF LOCOMOTOR ACTIVITY INDUCED BY CEREBRAL ISCHEMIA IN MONGOLIAN GERBILS
- Hypnotic and Sleep Quality-Enhancing Properties of Kavain in Sleep-Disturbed Rats
- Effect of Heat Exposure on Aminophylline-Induced Convulsions in Mice
- Antiparkinsonian Drugs and Their Neuroprotective Effects
- Protective Effect of Talipexole on MPTP-Treated Planarian, a Unique Parkinsonian Worm Model
- ENDOTHELIUM-INDEPENDENT VASORELAXATION INDUCED BY ACETYLCHOLINE
- Malfunction of Vascular Control in Lifestyle-Related Diseases : Preface
- Altered function of nitrergic nerves inhibiting sympathetic neurotransmission in mesenteric vascular beds of renovascular hypertensive rats
- First Principle Study of the Electron-transport Behavior of Porphyrin and Metalloporphyrin Wires
- 5-Hydroxytryptamine-induced Ca^-independent cGMP formation is mediated by nitric oxide in a nitric oxide synthase-independent manner in NG108-15 cells
- Acute Hyperglycemia and Hyperinsulinemia Enhance Adrenergic Vasoconstriction and Decrease Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in Pithed Rats
- Chronic Hyperinsulinemia Enhances Adrenergic Vasoconstriction and Decreases Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in Pithed Rats
- Age-Related Decrease in Calcitonin Gene-Related Peptide mRNA in the Dorsal Root Ganglia of Spontaneously Hypertensive Rats
- Electrocatalytic Oxidation of C-C Double Bond of Styrene Mediated with Copper Ion Immobilized in Polyaniline Matrix. Electrochemical Model Reaction of Quercetin-2,3-dioxygenase
- Electrocatalytic C-C Double Bond Cleavage Reaction of Styrene with Molecular Oxygen Mediated by CuCl_2
- Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats
- Regulation of Vascular Function by Perivascular Calcitonin Gene-Related Peptide-Containing Nerves
- Preface
- Lafutidine Facilitates Calcitonin Gene-Related Peptide (CGRP) Nerve-Mediated Vasodilation via Vanilloid-1 Receptors in Rat Mesenteric Resistance Arteries
- Effect of Adrenomedullin on Adrenergic Vasoconstriction in Mesenteric Resistance Arteries of the Rat
- Inhibitory Effects of Talipexole and Pramipexole on MPTP-InducedDopamine Reduction in the Striatum of C57BL/6N Mice
- LIPO-MICRODIALYSIS : A NEW MICRODIALYSIS METHOD FOR STUDYING THE PHARMACOKINETICS OF LIPOPHILIC SUBSTANCES
- Different Prostanoids Are Involved in Bradykinin-Induced Endothelium-Dependent and-Independent Vasoconstriction in Rat Mesenteric Resistance Arteries
- Long-Term Inhibition of Angiotensin Prevents Reduction of Periarterial Innervation of Calcitonin Gene-Related Peptide (CGRP)-Containing Nerves in Spontaneously Hypertensive Rats
- Decreased Depressor Response Mediated by Calcitonin Gene-Related Peptide(CGRP)-Containing Vasodilator Nerves to Spinal Cord Stimulation and Levels of CGRP mRNA of the Dorsal Root Ganglia in Spontaneously Hypertensive Rats
- Effects of Natriuretic Peptides on the Centrally Mediated Pressor Response to Clonidine in Freely Moving Rats
- Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats
- Characterization of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Resistance Arteries
- Nerve Growth Factor Suppresses Prostate Tumor Growth
- Age-Related Disappearance of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Vascular Beds
- A Modified Fluorescence Polarization Immunoassay Method Incorporating Fat Emulsion (FE-FPIA) to Determine Cyclosporin A Concentrations in Rat Skin
- UPTAKE AND RELEASE OF 5-HYDROXYTRYPTAMINE IN ADRENERGIC NERVES OF THE RAT MESENTERIC ARTERY
- EFFECTS OF DELTA-9-TETRAHYDROCANNABINOL ON THE CARDIOVASCULAR SYSTEM, AND PRESSOR AND BEHAVIORAL RESPONSES TO BRAIN STIMULATION IN RATS
- CARDIOVASCULAR CHANGES INDUCED BY LARGE DOSES OF CLONIDINE IN MICE
- Effect of Pharmacist Management on Serum Hemoglobin Levels with Renal Anemia in Hemodialysis Outpatients
- New Molecular Mechanisms for Cardiovascular Disease:Contribution of Endothelium-Derived Hyperpolarizing Factor in the Regulation of Vasoconstriction in Peripheral Resistance Arteries
- R-(-)-α-methylhistamine, a histamine H3 receptor agonist, induces endothelium-dependent vasodilation in rat mesenteric resistance arteries
- Noradrenaline Release Enhanced by Cholera Toxin and Pertussis Toxin in Rat Cerebral Cortical Slices
- Protection Against Dopaminergic Neurodegeneration in Parkinson’s Disease–Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson’s Disease–Linked PARK7
- New Molecular Mechanisms for Cardiovascular Disease : Contribution of Endothelium-Derived Hyperpolarizing Factor in the Regulation of Vasoconstriction in Peripheral Resistance Arteries
- New Molecular Mechanisms for Cardiovascular Disease : Preface
- Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats
- R-(−)-α-Methylhistamine, a Histamine H3 Receptor Agonist, Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries
- Endothelium-Derived Relaxing Factor-Mediated Vasodilation in Mouse Mesenteric Vascular Beds
- Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer's Disease: Tangle Formation, Amyloid-β, and Microglia in Alzheimer's Disease
- Protection Against Dopaminergic Neurodegeneration in Parkinson's Disease-Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson's Disease-Linked PARK7
- Adrenergic Stimulation-Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries
- Anandamide Induces Endothelium-Dependent Vasoconstriction and CGRPergic Nerve-Mediated Vasodilatation in the Rat Mesenteric Vascular Bed
- Hyperinsulinemia induces hypertension associated with neurogenic vascular dysfunction resulting from abnormal perivascular innervations in rat mesenteric resistance arteries
- Acute Lung Injury Associated With Systemic Inflammatory Response Syndrome Following Subarachnoid Hemorrhage : a Survey by the Shonan Neurosurgical Association
- Effect of Selective Serotonin Reuptake Inhibitors via 5-HT_ Receptors on L-DOPA-Induced Rotational Behavior in a Hemiparkinsonian Rat Model
- Detoxification of 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration by 5,5-Dimethyl-1-pyrroline N-Oxide, a Radical Trapper, in Hemiparkinsonian Rats
- Effect of Selective Serotonin Reuptake Inhibitors via 5-HT1A Receptors on L-DOPA-Induced Rotational Behavior in a Hemiparkinsonian Rat Model
- The Mechanisms of Electroconvulsive Stimuli in BrdU-Positive Cells of the Dentate Gyrus in ACTH-Treated Rats
- The Mechanisms of Electroconvulsive Stimuli in BrdU-Positive Cells of the Dentate Gyrus in ACTH-Treated Rats