Different Prostanoids Are Involved in Bradykinin-Induced Endothelium-Dependent and-Independent Vasoconstriction in Rat Mesenteric Resistance Arteries
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概要
- 論文の詳細を見る
Mechanisms underlying bradykinin-induced vasoconstriction were investigated in rat perfused mesenteric vascular beds with active tone. In preparations with intact endothelium, bolus injections of bradykinin (1 to 1,000 pmol) dose-dependently produced three-phase vascular effects, which consisted of a first-phase vasodilation followed by a second-phase vasoconstriction and a subsequent third-phase vasodilation; these effects were abolished by FR172357 (bradykinin B2-receptor antagonist), but not by des-Arg9-[Leu8]-bradykinin (bradykinin B1-receptor antagonist). In preparations with intact endothelium, indomethacin (cyclooxygenase inhibitor), seratrodast (thromboxane A2 (TXA2)-receptor antagonist), ONO-3708 (TXA2/prostaglandin H2 (PGH2)-receptor antagonist) or ozagrel (TXA2 synthesis inhibitor) markedly inhibited the bradykinin-induced vasoconstriction. In preparations without endothelium, the bradykinin-induced vasoconstriction was abolished by indomethacin and ONO-3708, while seratrodast and ozagrel had no effect. These results suggest that the endothelium-dependent vasoconstriction of bradykinin is mainly mediated by TXA2 and that prostanoids other than TXA2, probably PGH2, in mesenteric vascular smooth muscle are responsible for bradykinin-induced endothelium-independent vasoconstriction.
- 社団法人 日本薬理学会の論文
- 2004-02-01
著者
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KAWASAKI Hiromu
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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KUROSAKI Yuji
Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Ok
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Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Kurosaki Yuji
Department Of Clinical Pharmaceutical Science Faculty Of Pharmaceutical Sciences Graduate School Of
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Kawasaki H
Department Of Clinical Pharmaceutical Science Graduate School Of Natural Science And Technology Okay
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NAWA Hideki
Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Ok
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Nawa Hideki
Department Of Clinical Pharmaceutical Science Graduate School Of Natural Science And Technology Okay
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Kurosaki Yuji
Department Of Clinical Pharmaceutical Science Graduate School Of Natural Science And Technology Okay
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