Nerve Growth Factor Suppresses Prostate Tumor Growth
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概要
- 論文の詳細を見る
Nerve growth factor (NGF) facilitates reinnervation of perivascular nerves that regulate vascular tone and blood flow. This study investigated whether NGF prevents tumor growth by promoting neuronal regulation of tumor blood flow. The growth rate of DU145 prostate carcinoma cells subcutaneously implanted into nude mice was significantly inhibited by subcutaneous NGF administration. Significant suppression of tumor growth continued after withdrawing NGF. NGF increased vascular smooth muscle cells in tumor tissues, but had no cytotoxic action on tumor cells in vitro. These results suggest that NGF prevents tumor growth via an indirect effect, probably innervation or maturation of the tumor neovasculature.
- 社団法人 日本薬理学会の論文
- 2010-04-20
著者
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Hobara Narumi
Department Of Life Science Okayama University Of Science
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Goda Mitsuhiro
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Goda Mitsuhiro
Department Of Clinical Pharmaceutical Science Graduate School Of Natural Science And Technology Okay
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Kawasaki Hiromu
Dep. Of Clinical Pharmacology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okay
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Kawasaki Hiromu
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
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Kitamura Yoshihisa
Department Of Pharmaceutical Care And Health Science Graduate School Of Medicine Dentistry And Pharm
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Kawasaki Hiromu
岡山大学 医歯薬学総合研究科臨床薬学
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Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Kawasaki Yoichi
Department Of Pharmacy Okayama University Hospital
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Hobara Narumi
Department Of Clinical Pharmaceutical Science Faculty Of Pharmaceutical Science Graduate School Of B
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ATAGI Saori
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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AMITANI Keisuke
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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Atagi Saori
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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Hashikawa Hobara
Department Of Life Science Okayama University Of Science
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Kitamura Yoshihisa
Department Of Pharmaceutical Care And Health Science Graduate School Of Medicine Dentistry And Pharm
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Amitani Keisuke
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
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KITAMURA Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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