Effects of Capsaicin on Intestinal Cephalexin Absorption in Rats(Biopharmacy)
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概要
- 論文の詳細を見る
The effects of capsaicin on intestinal cephalexin absorption were investigated by means of in situ single pass perfusion in rats to clarify whether this pungent compound present in spice is a potential factor altering the intestinal drug absorption processes. Under the control condition, cephalexin was absorbed at a rate of 1.16±0.08 and 0.90±0.06 nmol/min/cm in the jejunum and ileum, respectively; The intestinal cephalexin absorption rate was decreased when capsaicin was dissolved in the perfusate at a concentration of 400 μM, being 0.54±0.07 and 0.46±0.10 nmol/min/cm in the jejunum and ileum, respectively. The inhibitive effect of capsaicin on intestinal cephalexin absorption was diminished when ruthenium red, a non-selective inhibitor of the transient receptor potential (TRP) cation channels, was intravenously infused into the rat during the experiment. Moreover, when we evaluated the paracellular permeability of cephalexin by utilizing a competitive inhibitor, glycylsarcosine, it was demonstrated that glycylsarcosine-insensitive intestinal cephalexin absorption in the jejunum was increased by 4.5 times in the presence of 400 μM capsaicin. These findings indicate that capsaicin affects both transcellular and paracellular pathways of intestinal cephalexin absorption by interacting with the TRP cation channels in intestinal tissues, in which capsaicin seems to change the transport activity of H^+/peptide co-transporter 1 (PEPT1), and to a lesser degree, it seems to alter the paracellular permeability of the intestinal epithelia.
- 社団法人日本薬学会の論文
- 2007-03-01
著者
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KOMORI Yukiko
Graduate School of Science, Osaka University
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Komori Yukiko
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Komori Yukiko
岡山大学 大学院医歯薬学総合研究科
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Aiba Tetsuya
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Kurosaki Yuji
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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NAKAI Chie
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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SUGIYAMA Risa
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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KAWASAKI Hiromu
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Aiba Tetsuya
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Univ.
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Kawasaki Hiromu
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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Kawasaki Hiromu
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Kurosaki Y
Department Of Clinical Pharmaceutical Science Graduate School Of Natural Science And Technology Okay
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Kurosaki Y
The Department Of Clinical Pharmaceutical Science Graduate School Of Natural Science And Technology
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Kurosaki Yuji
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Kurosaki Yuji
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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Nakai Chie
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Sugiyama Risa
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University
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