Malfunction of Vascular Control in Lifestyle-Related Diseases : Distribution of Adrenomedullin-Containing Perivascular Nerves and Its Alteration in Hypertension
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概要
- 論文の詳細を見る
The distribution and characteristics of adrenomedullin (AM)-containing perivascular nerves in the rat mesenteric artery were investigated using immunohistochemical techniques. Many fibers containing AM-like immunoreactivity (LI) were observed in the adventitia of mesenteric arteries, which were densely innervated by calcitonin gene-related peptide (CGRP)- and neuropeptide Y (NPY)-LI fibers. AM-LI, CGRP-LI, and NPY-LI fibers were abolished by cold storage denervation. Capsaicin pretreatment abolished AM-LI and NPY-LI fibers but not NPY-LI fibers. NPY-LI fibers but not AM-LI and CGRP-LI fibers disappeared after treatment with 6-hydroxydopamine. There were many AM-LI positive cells in the dorsal root ganglia, where AM mRNA was detected. In a double immunofluorescence study, AM-LI was found in CGRP-LI fibers, although some fibers contained AM-LI alone. The density of AM-LI fibers was lower in SHR than in WKY mesenteric arteries. These results suggest that the mesenteric artery is innervated by AM-containing perivascular nerves and AM may have a neurotransmitter role in the regulation of vascular tone.
- 社団法人 日本薬理学会の論文
- 2004-12-01
著者
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GODA Mitsuhiro
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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KAWASAKI Hiromu
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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Hobara Narumi
Department Of Life Science Okayama University Of Science
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Goda Mitsuhiro
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Goda Mitsuhiro
Department Of Clinical Pharmaceutical Science Graduate School Of Natural Science And Technology Okay
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NAKAMURA Arisa
Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Ok
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Nakamura Arisa
The Department Of Clinical Pharmaceutical Science Graduate School Of Natural Science And Technology
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Nakamura Arisa
Department Of Clinical Pharmaceutical Science Graduate School Of Natural Science And Technology Okay
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Kawasaki Hiromu
Dep. Of Clinical Pharmacology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okay
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Kawasaki Hiromu
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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Kawasaki Hiromu
岡山大学 医歯薬学総合研究科臨床薬学
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Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Hobara Narumi
Department Of Clinical Pharmaceutical Science Faculty Of Pharmaceutical Science Graduate School Of B
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Hashikawa Hobara
Department Of Life Science Okayama University Of Science
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