Neurogenic Vascular Responses in Male Mouse Mesenteric Vascular Beds
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概要
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Rat mesenteric arteries were maintained by both adrenergic vasoconstrictor nerves and calcitonin gene–related peptide (CGRP) vasodilator nerves. However, functions of these nerves in a pathophysiological state have not fully been analyzed. The use of disease models developed genetically in mice is expected to clarify neural function of perivascular nerves. Thus, we investigated basic mouse vascular responses. Mesenteric vascular beds isolated from male C57BL/6 mouse were perfused with Krebs solution and perfusion pressure was measured. Periarterial nerve stimulation (PNS, 8 – 24 Hz) induced frequency-dependent vasoconstriction, which increased flow rate–dependently. PNS-induced vasoconstriction was abolished by tetrodotoxin (neurotoxin) and guanethidine (adrenergic neuron blocker) and blunted by prazosin (<I>α</I><SUB>1</SUB>-adrenoceptor antagonist). Injection of norepinephrine caused vasoconstriction, which was abolished by prazosin. In preparations with active tone, PNS (1 – 8 Hz) induced frequency-dependent vasodilation, which was inhibited by tetrodotoxin, capsaicin (CGRP depletor), and CGRP8-37 (CGRP-receptor antagonist). Injections of CGRP, acetylcholine, and sodium nitroprusside induced vasodilations. Vasodilator response to CGRP was inhibited by CGRP8-37. Immunohistochemical study showed innervation of tyrosine hydroxylase- and CGRP-immunopositive fibers in mesenteric arteries and veins. These results suggest that male mouse mesenteric vascular beds are useful for studying neural regulation of mesenteric arteries, which are innervated by adrenergic and CGRPergic nerves regulating vascular tone.
- 公益社団法人 日本薬理学会の論文
著者
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Zamami Yoshito
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Fujiwara Hiroki
Department Of Applied Chemistry Kansai University
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Higuchi Hiroshi
Division Of Neuroeurgery Department Of Brain Diseases Tohoku University School Of Medicine
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Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Hashikawa-Hobara Narumi
Department of Life Science, Okayama University of Science, Japan
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Hashikawa Hobara
Department Of Life Science Okayama University Of Science
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Takatori Shingo
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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Wake Yoshihiro
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Tangsucharit Panot
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Goda Mitsuhiro
Division Of Pharmacology Molecular And Cellular Medicine Niigata University Graduate School Of Medical And Dental Sciences
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Higuchi Hiroshi
Division of Pharmacology, Molecular and Cellular Medicine, Niigata University Graduate School of Medical and Dental Sciences, Japan
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Tangsucharit Panot
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan
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Fujiwara Hiroki
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan
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Zamami Yoshito
Department of Molecular Design for Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan
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