Age-Related Disappearance of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Vascular Beds
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概要
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We previously reported that endothelium-derived hyperpolarizing factor (EDHF)–mediated response time-dependently suppressed methoxamine-induced vasoconstriction in mesenteric vascular beds isolated from 8-week-old rats. We investigated age-related changes in endothelial regulation of methoxamine-induced vasoconstriction. Mesenteric vascular beds isolated from young (8-week-old) to adult (16-week-old) rats were perfused, and changes in perfusion pressure induced by continuous perfusion of methoxamine or high KCl (60 mM) were measured over 180 min. In young preparations with intact endothelium, methoxamine-induced vasoconstriction time-dependently decreased to 20% of the initial levels, while time-dependent reduction was not observed in adult preparations. High KCl–induced vasoconstriction in young and adult preparations did not show time-dependent reduction. Endothelium removal abolished time-dependent reduction of methoxamine-induced vasoconstriction in young preparations and significantly attenuated vasoconstriction in adult preparations. Indomethacin, seratrodast, or tempol but not catalase significantly reduced methoxamine-induced vasoconstriction in adult preparations with endothelium. A23187 (Ca2+-ionophore)–, but not acetylcholine-, induced endothelium-dependent vasodilation in the presence of NG-<sc>L</sc>-nitro arginine methyl ether in adult preparations was significantly smaller than that in young preparations. These findings suggest that the inhibitory effect of mesenteric vascular endothelium on methoxamine-induced vasoconstriction disappears with aging by reducing EDHF and increasing endothelium-derived contracting factors and reactive oxygen species.
- 社団法人 日本薬理学会の論文
- 2009-12-20
著者
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Jin Xin
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Jin Xin
Department Of Applied Chemistry Harbin Institute Of Technology
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Hobara Narumi
Department Of Life Science Okayama University Of Science
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Zamami Yoshito
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Kawasaki Hiromu
Dep. Of Clinical Pharmacology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okay
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Kawasaki Hiromu
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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Koyama Toshihiro
Dep. Of Pharmaceutical Care And Health Sciences Graduate School Of Medicine Dentistry And Pharmaceut
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Koyama Toshihiro
Department Of Applied Chemistry Faculty Of Engineering Hiroshima University
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Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
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Kitamura Yoshihisa
Department Of Pharmaceutical Care And Health Science Graduate School Of Medicine Dentistry And Pharm
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Kawasaki Hiromu
岡山大学 医歯薬学総合研究科臨床薬学
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Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Kawasaki Yoichi
Department Of Pharmacy Okayama University Hospital
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Hobara Narumi
Department Of Clinical Pharmaceutical Science Faculty Of Pharmaceutical Science Graduate School Of B
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Li Simin
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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SATOH OTONASHI
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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SUN Pengyuan
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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Satoh-Otonashi Yukiko
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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Satoh Otonashi
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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Hashikawa Hobara
Department Of Life Science Okayama University Of Science
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Kitamura Yoshihisa
Department Of Pharmaceutical Care And Health Science Graduate School Of Medicine Dentistry And Pharm
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SUN Pengyuan
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
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KITAMURA Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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