Inhibitory Effects of Antiparkinsonian Drugs and Caspase Inhibitors in a Parkinsonian Flatworm Model
スポンサーリンク
概要
- 論文の詳細を見る
It has been known that rotenone and 1-methyl-4-phenylpyridinium ion (MPP+, a metabolite of MPTP), which inhibit mitochondrial complex I, are useful tools for parkinsonian models in vertebrates such as primates and rodents. Planarian, an invertebrate flatworm, has a high potential for regeneration, and dopamine plays a key role in its behavior. In the present study, we examined a cloned planarian, the GI strain from Dugesia japonica. Planarians that were treated with rotenone or MPTP underwent autolysis and individual death in a concentration- and time-dependent manner. In addition, these effects induced by rotenone or MPTP were inhibited by several antiparkinsonian drugs and caspase inhibitors. These results suggest that the degeneration of planarian dopaminergic system induced by rotenone or MPTP may be mediated through caspase-like activation.
- 社団法人 日本薬理学会の論文
- 2003-06-01
著者
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Sawada Hideyuki
京都大学 医学研究科脳病態生理学講座臨床神経学
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Sawada Hideyuki
Department Of Neurology Graduate School Of Medicine Kyoto University
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Takata Kazuyuki
Faculty Of Pharmaceutical Sciences Hoshi University
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Taniguchi Takashi
Department of Geophysics, Faculty of Science, Hokkaido University
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Taniguchi T
Department Of Neurobiology Kyoto Pharmaceutical University
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Takahashi Kazunori
京都薬科大学 病態生理学
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Taniguchi Takashi
京都薬科大学 病態生理学
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Agata K
Dep. Of Biophysics Graduate School Of Sci. Kyoto Univ.
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Agata Kiyokazu
Lab. Mol. Dev. Biol. Grad. Sch. Sci. Kyoto Univ.
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Agata Kiyokazu
Evolutionary Regeneration Group Center For Developmental Biology Riken
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Agata Kiyokazu
理化学研究所発生再生科学総合研究センター
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Agata Kiyokazu
Genome Resource And Analysis Subunit Riken Center For Developmental Biology
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Shimohama Shun
Department of Neurology, Sapporo Medical University School of Medicine
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KITAMURA Yoshihisa
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Watanabe K
Tohoku Univ. Sendai Jpn
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Watanabe Kohei
Canon Inc.
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Shimohama S
Kyoto Univ. Kyoto Jpn
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Shimohama Shun
Department Of Neurology Faculty Of Medicine Kyoto University
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Agata Kiyokazu
Dep. Of Biophysics Graduate School Of Sci. Kyoto Univ.
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Agata Kiyokazu
Laboratory For Evolutionary Regeneration Center For Developmental Biology Riken
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Agata Kiyokazu
Riken Cdb Evo.
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Agata Kiyokazu
Evolutionary Regeneration Biology Group Riken Center For Developmental Biology
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Watanabe Kenji
Graduate School Of Life Science University Of Hyogo
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Orii Hidefumi
Laboratory of Regeneration Biology, Department of Life Science, Faculty of Science, Himeji Institute
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Watanabe Kenji
Laboratory of Regeneration Biology, Department of Life Science, Faculty of Science, Himeji Institute
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INDEN Masatoshi
Department of Neurobiology, Kyoto Pharmaceutical University
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TAKATA Kazuyuki
Department of Neurobiology, Kyoto Pharmaceutical University
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Takata Kazuyuki
Department Of Mechanical Engineering Aichi Institute Of Technology
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Inden Masatoshi
Department Of Neurobiology And 21st Century Coe Program Kyoto Pharmaceutical University
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Agata Kiyokazu
Group For Evolutionary Regeneration Biology Center For Developmental Biology Riken Kobe
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SANADA Hisakazu
Department of Neurobiology, Kyoto Pharmaceutical University
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MOCHII Makoto
Laboratory of Regeneration Biology, Department of Life Science, Faculty of Science, Himeji Institute
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Orii H
Graduate School Of Life Science University Of Hyogo
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Orii Hidefumi
Department Of Life Science Graduate School Of Science Himeji Institute Of Technology
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Orii Hidefumi
Laboratory Of Regeneration Biology Department Of Life Science Graduate School Of Science Himeji Inst
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Takeuchi Kosei
Kan Research Institute Inc. Kobe Mi R&d Center
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Watanabe Kazutada
Department Of Experimental Biology Tokyo Metropolitan Institute Of Gerontology
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Takenawa Tadaomi
Division Of Biochemistry Institute Of Medical Science University Of Tokyo
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Kanai Yoshihito
Department Of Pharmaceutical Care And Health Sciences Okayama University Graduate School Of Medicine
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Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
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Kitamura Yoshihisa
Department Of Pharmacology Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical Unive
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Kitamura Y
Department Of Neurobiology Kyoto Pharmaceutical University
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Kitamura Y
Shimizu Pharmaceutical Co. Ltd. Shizuoka Jpn
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Taira Takahiro
Graduate School Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology Co
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Mochii M
Graduate Univ. Advanced Studies Okazaki Jpn
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Sanada Hisakazu
Department Of Neurology Graduate School Of Medicine Kyoto University
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Agata Kiyokazu
Lab. For Mol. Dev. Biol. Dept. Of Biophys. Grad. Sch. Of Sci. Kyoto Univ.
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Takano T
Dep. Of Neurobiology Kyoto Pharmaceutical Univ.
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Taniguchi Takashi
Department Of Geophysics Faculty Of Science Hokkaido University
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Sanada Hisakazu
Department Of Molecular Toxicology And Global Center Of Excellence Program School Of Pharmaceutical
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Watanabe Kenji
Laboratory Of Regeneration Biology Department Of Life Science Graduate School Of Science Himeji Inst
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Watanabe Kenji
Laboratory Of Food Material Engineering Faculty Of Agriculture Gifu University
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Taniguchi Takashi
Department Of Dermatology Faculty Of Medicine University Of Tokyo
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Inden Masatoshi
Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University
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Takata Kazuyuki
Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University
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TANIGUCHI Takashi
Department of Computational Science and Engineering, Nagoya University
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Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
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Taniguchi Takashi
Department of Biology, Kyoto Pharmaceutical University
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KITAMURA Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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