Inhibitory Effects of Talipexole and Pramipexole on MPTP-InducedDopamine Reduction in the Striatum of C57BL/6N Mice
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概要
- 論文の詳細を見る
We have investigated the effects of two novel antiparkinsonian drugs, talipexole (Domin®)and pramipexole, on MPTP-induced dopamine (DA)reduction in the striatum of C57BL/6N mice in comparison with those of bromocriptine. Fifteen days after MPTP treatment (25 mg/kg, i.p., given daily for 5 days), the DA content in the striatum was decreased to 40-60010 of the control value. Among the three dopamine receptor agonists, talipexole and pramipexole (1 mg/kg, i.p., once a day for 20 days)more significantly suppressed the MPTP-induced DA reduction in the striatum than bromocriptine (10 mg/kg, i.p., once a day for 20 days). Talipexole did not influence [<SUP>3</SUP>H]MPP<SUP>+</SUP> uptake into striatal synaptosomes. These results suggest that talipexole and pramipexole have a protective effect against MPTP-induced DA reduction in the striatum of C57BL/6N mice.
- 社団法人 日本薬理学会の論文
- 1997-05-01
著者
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KITAMURA Yoshihisa
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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NOMURA Yasuyuki
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Kohno Yasuko
Product Management Department Marketing Division Nippon Boehringer Ingelheim Co. Ltd.
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Kohno Yasuko
Product Management Department Marketing Division Nippon Boehringer Ingelheim
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Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
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Kitamura Yoshihisa
Department Of Pharmacology Faculty Of Pharmaceu Tical Sciences Hokkaido University
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NAKAZAWA Minako
Department of Pharmacology, Faculty of Pharmaceu tical Sciences, Hokkaido University
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Nakazawa Minako
Department Of Pharmacology Faculty Of Pharmaceu Tical Sciences Hokkaido University
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Nomura Yasuyuki
Department Of Pharmacology Faculty Of Pharmaceu Tical Sciences Hokkaido University
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Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
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KITAMURA Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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