INVOLVEMENT OF CENTRAL NORADRENERGIC SYSTEM IN THYROTROPIN-RELEASING HORMONE-INDUCED BEHAVIORAL EXCITEMENT IN 6-OHDOPA-TREATED, INFANT RATS
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概要
- 論文の詳細を見る
A subcutaneous (s.c.) injection of tyrotropin-releasing hormone (TRH) 20 mg/kg, produced body shake and struggle, consequendy induced an increase of count in ANIMEX activity meter in 7-day-old rats pretreated with 6-hydroxydopa (6-OHDOPA), 75 mg/kg, on days 0,2 and 4. TRH-induced behavioral excitement was markedly attenuated in the infant animals which were injected desmethylimipramine, 5 mg/kg, 30 min before 6-OHDOPA on days 0,2 and 4. It is suggested that central catecholaminergic, in particular, noradrenergic system is involved in TRH-induced body shake and struggle in 6-OHDOPA-treated, infant rats.
- 公益社団法人日本薬学会の論文
著者
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NOMURA Yasuyuki
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Nomura Yasuyuki
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
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Segawa Tomio
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
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Oki Keiko
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
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Oki Keiko
Department Of Laboratory Medicine Shinshu University Hospital
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