STUDIES ON PLASMA FACTOR INVOLVED IN 5-HYDROXYTRYPTAMINE RELEASE FROM BLOOD PLATELETS BY BACTERIAL ENDOTOXIN:III. MECHANISM OF ACTION OF 5-HYDROXYTRYPTAMINE RELEASING FACTOR
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概要
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It has been well established that 5-hydroxytryptamine (5HT) release from blood platelets by bacterial endotoxin (lipopolysaccharide, LPS) requires the presence of plasma factor and calcium ion (1-4). Recently, separation and purification of plasma factor with 5HT releasing activity has been reported by Nomura and Takagi (5, 6). They estimated that this factor could be mainly prothrombin-like protein, however, the mechanism of 5HT release by this factor is unknown. Thrombin has been considered an enzyme with 5HT releasing activity from the blood platelets and mechanism of its action was studied by Gainter et al. (7), Pletscher et al. (8) and Markwardt et al. (9-11).<BR> The purpose of the present experiment is to investigate the mechanism of action of 5HT releasing factor purified using a previous method (6), as well as making a comparison with thrombin.
- 公益社団法人 日本薬理学会の論文
著者
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NOMURA Yasuyuki
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Takagi Hiroshi
Department Of Bioscience Faculty Of Bioscience Fukui Prefectural University
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OKADA Toshikazu
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University
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