Age Related Changes in the Inhibitory Effect of Clonidine on High K^+-Evoked Noradrenaline Release from Brain Slices of Rats
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概要
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The effects of clonidine on a high K^+-induced release of noradrenaline (NA) were studied in 70-d-and 2-year-old rats. Treatment with 0.1 and 1.0μM clonidine significantly (p < 0.01) inhibited 20mM KCl-evoked L-[^3H]NA release from cerebral cortical slices in 70-d-old rats. The amounts of high K^+-evoked L-[^3H]NA release were markedly decreased at 2 years, compared to that at 70 d. In addition, the inhibitory effects of clonidine on high K^+-evoked L-[^3H]NA release were no longer observed in 2-year-old animals. These results suggested that presynaptic functions, including the modulation of NA release by α_2-adrenoceptors, could become low in the brains of the 2-year-old rats.
- 公益社団法人日本薬学会の論文
著者
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NOMURA Yasuyuki
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Oi Shangbin
Department Of Pharmacology Research Institute For Wakan-yaku (oriental Medicine) Toyama Medical And
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NOMURA Yasuyuki
Department of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicine), Toyama Medical and Pharmaceutical University:Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University
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- Preface
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