INFLUENCE OF THYROTROPIN-RELEASING HORMONE ON GENERAL BEHAVIOR AND STRIATAL [^3H] SPIPERONE BINDING IN DEVELOPING RATS
スポンサーリンク
概要
- 論文の詳細を見る
An intraperitoneal administration of thyrotropin-releasing hormone (TRH, 2 or 20 mg/kg) produced behavioral excitement and consequently an increase in ANIMEX counts 15 min after the injection in a dose-dependent manner in 70-day-old rats. On the other hand, TRH (2 or 20 mg/kg)-induced behavioral excitement appeared more slowly (90-150 min) and more persistently in 7-day-old animals than in 70-day-old animals. TRH (2 or 20 mg/kg) significantly reduced specific [^3H] spiperone binding to striatal membranes in 7- and 70-day-old rats compared to control, when the binding was examined in the membranes obtained from animals sacrificed 15 min and 150 min following TRH injection. In vitro addition of TRH up to 0.1 mM did not affect [^3H] spiperone binding on days 7 and 70. From these results, it is suggested that striatal dopamine receptors could be involved in TRH-induced behavioral excitement in developing rats.
- 公益社団法人日本薬学会の論文
著者
-
NOMURA Yasuyuki
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
-
Nomura Yasuyuki
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
-
Segawa Tomio
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
-
Kinoshita Yumi
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
-
Oki Keiko
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
-
Oki Keiko
Department Of Laboratory Medicine Shinshu University Hospital
-
Kinoshita Yumi
Department of Electronics, Kyoto Institute of Technology, Kyoto 606-8585, Japan
関連論文
- Deficits in learning ability and aging of skin in both strains of senescence-accelerated mouse (SAM) P8 and P10 : neuropathological, neurochemical, histological and pharmacological analysis(Chemical & Pharmacological study)
- Age-Related Alterations in the Expression of Glial Cell Line-Derived Neurotrophic Factor in the Senescence-Accelerated Mouse Brain
- Depressive Behavior and Alterations in Receptors for Dopamine and 5-Hydroxytryptamine in the Brain of the Senescence Accelerated Mouse (SAM)-P10
- Influence of Aging on Rolipram-Sensitive Phosphodiesterase Activity and [^3H] Rolipram Binding in the Rat Brain
- The mRNA Expression of Serotonin 2C Subtype Receptors Uncoupled With Inositol Hydrolysis in NG108-15 Cells
- Possible Involvement of Rapamycin-Sensitive Pathway in Bcl-2 Expression in Human Neuroblastoma SH-SY5Y Cells
- APOMORPHINE- AND HALOPERIDOL-INDUCED CHANGE IN 3,4-DIHYDROXYPHENYLACETIC ACID CONTENT IN THE MESOLIMBIC-STRIATUM OF THE DEVELOPING RAT
- TEK/Tie2 Is a Novel Gene Involved in Endoplasmic Reticulum Stress
- Alteration of Leptin-Induced STAT3 Activation in the Brain of Senescence-Accelerated Mouse (SAM) P8(Pharmacology)
- Aspirin and Sodium Salicylate Protect Brain Cell Death Against Endoplasmic Reticulum Stress
- Possible Role of Interleukin-6 in PC12 Cell Death Induced by MPP^+ and Tetrahydroisoquinoline
- Cholecystokinin Inhibits Food Intake Independent of Interleukin-1β Expression in the Brain(Pharmacology)
- Age-Related Alterations in the Expression of Glial Cell Line-Derived Neurotrophic Factor in the Senescence-Accelerated Mouse Brain
- INTERACTIONS OF β-ADRENOCEPTOR BLOCKING AGENTS WITH SEROTONIN RECEPTOR SUBTYPES-SPECIAL REFERENCE TO THEIR PROPHYLACTIC EFFECT ON MIGRAINE
- 5-Hydroxytryptamine-induced Ca^-independent cGMP formation is mediated by nitric oxide in a nitric oxide synthase-independent manner in NG108-15 cells
- Novel Functions of Ubiquitin Ligase HRD1 With Transmembrane and Proline-Rich Domains
- The Age-Related Degeneration of Oligodendrocytes in the Hippocampus of the Senescence-Accelerated Mouse (SAM) P8 : A Quantitative Immunohistochemical Study(Pharmacology)
- Manganese Superoxide Dismutase Is Induced by Endoplasmic Reticulum Stress through IRE1-Mediated Nuclear Factor (NF)-κB and AP-1 Activation(Biochemistry/Molecular Biology)
- Activation Signal of Nuclear Factor-κB in Response to Endoplasmic Reticulum Stress is Transduced via IRE1 and Tumor Necrosis Factor Receptor-Associated Factor 2
- Effects of S-Nitroso-Cysteine on Proteins That Regulate Exocytosis in PC12 Cells: Inhibitory Effects on Translocation of Synaptophysin and ADP-Ribosylation of GTP-Binding Proteins
- Stimulation of Noradrenaline Release by T-588, a Cognitive Enhancer, in PC12 Cells
- The Effects of T-588, a Novel Cognitive Enhancer, on Noradrenaline Uptake and Release in Rat Cerebral Cortical Slices
- ATP Receptor-Mediated Increase of Ca Ionophore-Stimulated Arachidonic Acid Release from PC12 Pheochromocytoma Cells
- Effects of Protein Kinase C and A Activation on ATP-Stimulated Release of [^3H] Noradrenaline from PC12 Cells
- Anomalous Diffusion in the Kicked Harper System : Condensed Matter and Statistical Physics
- Effects of Selective Muscarinic Antagonists, Pirenzepine and AF-DX 116,on Passive Avoidance Tasks in Mice
- A novel factor, TA20, involved in neuronal differentiation: cDNA cloning and expression
- Extracellular Signal Regulated Protein Kinase and c-Jun N-Terminal Kinase are Involved in m1 Muscarinic Receptor-Enhanced Interleukin-2 Production Pathway in Jurkat Cells
- Senescence-Accelerated Mouse (SAM) as an Animal Model of Senile Dementia: Pharmacological, Neurochemical and Molecular Biological Approach
- Muscarinic Acetylcholine Receptors on Rat Thymocytes:Their Possible Involvement in DNA Fragmentation
- Destruction of Magnetic Surfaces near a Separatrix of a Stellarator Attributed to Perturbations of Magnetic Fields
- Inhibitory Effects of Talipexole and Pramipexole on MPTP-InducedDopamine Reduction in the Striatum of C57BL/6N Mice
- EFFECTS OF 6-HYDROXYDOPA AND 5, 6-DIHYDROXYTRYPTOPHAN TREATMENT ON SPONTANEOUS MOTOR ACTIVITY AND BRAIN MONOAMINES IN MICE
- TEK/Tie2 Is a Novel Gene Involved in Endoplasmic Reticulum Stress
- INFLUENCES OF VERAPAMIL, X-537A, A-23187 AND ADENOSINE 3, 5-CYCLIC MONOPHOSPHATE ON RELEASE OF 5-HYDROXYTRYPTAMINE FROM RAT BRAIN SLICES
- EFFECT OF APOMORPHINE ON MORPHINE-INDUCED DECREASE IN LOCOMOTOR ACTIVITY AND INCREASE IN DOPAMINE TURNOVER IN RATS
- 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]imino]-2,4-imidazolidinedione (Dantrolene), an Inhibitor of Intracellular Ca^ Mobilization, Impairs Avoidance Performance and Spatial Memory in Mice
- A COMPARISON OF THE INHIBITORY EFFECTS OF CERTAIN ANTIPARKINSONIAN AGENTS ON DOPAMINE ACCUMULATION INTO THE RAT STRIATUM
- EFFECT OF COLD TREATMENT AND SOME DRUGS ON THE 5-HYDROXYTRYPTAMINE UPTAKE BY RABBIT BLOOD PLATELETS AND THEIR ULTRASTRUCTURE
- EFFECT OF CONCANAVALIN A ON 3H-5-HYDROXYTRYPTAMINE UPTAKE IN RABBIT BLOOD PLATELETS: INTERACTION WITH ADENYLATE CYCLASE ACTIVITY
- INFLUENCE OF THYROTROPIN-RELEASING HORMONE ON GENERAL BEHAVIOR AND STRIATAL [^3H] SPIPERONE BINDING IN DEVELOPING RATS
- INVOLVEMENT OF CENTRAL NORADRENERGIC SYSTEM IN THYROTROPIN-RELEASING HORMONE-INDUCED BEHAVIORAL EXCITEMENT IN 6-OHDOPA-TREATED, INFANT RATS
- Noradrenaline Release Enhanced by Cholera Toxin and Pertussis Toxin in Rat Cerebral Cortical Slices
- Involvement of Polyubiquitin Chains via Specific Chain Linkages in Stress Response in Mammalian Cells(Biochemistry)
- DEVELOPMENT OF REGIONAL ACTIVITIES OF 2', 3'-CYCLIC NUCLEOTIDE 3'-PHOSPHOHYDROLASE AND CARBONIC ANHYDRASE IN THE RAT BRAIN : INFLUENCE OF 6-HYDROXYDOPA
- 6-HYDRXYDOPA-INDUCED STIMULATION OF ORNITHINE DECARBOXYLASE ACTIVITY IN THE DEVELOPING RAT BRAIN
- THE EFFECT OF PIPERIDINE AND PIPECOLIC ACID ON HIGH POTASSIUM-INDUCED RELEASE OF NORADRENALINE, SEROTONIN AND GABA FROM RAT BRAIN SLICES
- INFLUENCE OF PIPERIDINE AND PIPECOLIC ACID ON THE UPTAKE OF MONOAMINES, GABA AND GLYCINE INTO P_2 FRACTIONS OF THE RAT BRAIN AND THE SPINAL CORD
- SUBCELLULAR LOCALIZATION OF DOPAMINE IN THE RAT STRIATUM
- expression of mRNA for a neuronal differentiation factor, TA20, in developing rat brains
- MECHANISM FOR THE INCREASE OF BRAIN 5-HYDROXY-TRYPTAMINE AND 5-HYDROXYINDOLEACETIC ACID FOLLOWING Δ9-TETRAHYDROCANNABINOL ADMINISTRATION TO RATS
- SOLUBILIZATION AND CHARACTERIZATION OF SUBSTANCE P BINDING PROTEIN FROM BOVINE BRAIN STEM
- The involvement of glial NO synthase/NO in neuronal apoptosis in the brain
- INFLUENCE OF NEONATAL TREATMENT WITH 6-HYDROXYDOPA ON CLONIDINE-INDUCED LOCOMOTOR STIMULATION IN THE INFANT RAT
- HIGH POTASSIUM-INDUCED, CALCIUM-DEPENDENT MONOAMINE RELEASE FROM BRAIN SLICES OF THE NEWBORN RAT
- STRIATAL DOPAMINE CONTENT REDUCED IN DEVELOPING RATS TREATED WITH 6-HYDROXYDOPA
- ONTOGENESIS OF THE DOPAMINE UPTAKE INTO P2 FRACTIONS AND SLICES OF THE RAT BRAIN
- EFFECTS OF CERTAIN DRUGS AND ENZYMES ON THE ELECTROPHORETIC MOBILITY OF RABBIT BLOOD PLATELETS
- REGIONAL CHANGES IN BRAIN CATECHOLAMINE CONTENT FOLLOWING ADMINISTRATION OF GUANETHIDINE TO NEONATAL RATS
- INFLUENCES OF SODIUM, OUABAIN AND TRICYCLIC ANTIDEPRESSANT DRUGS ON L-[3H]NOREPINEPHRINE UPTAKE INTO SYNAPTOSOMAL FRACTIONS OF DEVELOPING RAT BRAIN
- Improvement of Severe Retrocochlear Hearing Loss and Vestibular Disorders Caused by Ruptured Brainstem Cavernous Angioma
- EFFECT OF IMIPRAMINE ON CENTRAL 5-HYDROXYTRYPTAMINE TURNOVER AND METABOLISM IN RATS
- Roles of Muscarinic Acetylcholine Receptors in Interleukin-2 Synthesis in Lymphocytes
- FURTHER OBSERVATION ON THE LACK OF ACTIVE UPTAKE SYSTEM FOR SUBSTANCE P IN THE CENTRAL NERVOUS SYSTEM
- SUBSTANCE P IN THE CENTRAL NERVOUS SYSTEM OF RABBITS : UPTAKE SYSTEM DIFFERS FROM PUTATIVE TRANSMITTERS
- EFFECT OF ENKEPHALIN AND SUBSTANCE P ON SYMPATHETIC NERVE TRANSMISSION IN MOUSE VAS DEFERENS
- SIGNAL TRANSDUCTION FROM CATECHOLAMINE RECEPTORS TO ADENYLATE CYCLASE VIA GTP-BINDING PROTEINS IN ADULT AND OLD RAT BRAIN
- Preface
- BRAIN SEROTONIN METABOLISM AND Δ9-TETRAHYDROCANNABINOL-INDUCED MURICIDE BEHAVIOR IN RATS
- Age Related Changes in the Inhibitory Effect of Clonidine on High K^+-Evoked Noradrenaline Release from Brain Slices of Rats
- INFLUENCE OF NEONATAL 6-HYDROXYDOPA TREATMENT ON FUNCTIONAL DEVELOPMENT IN THE STRIATUM AND HEART
- THE ISOLATION OF HIGHLY 5-HYDROXYTRYPTAMINE CONCENTRATED FRACTION FROM RABBIT DUODENAL MUCOUS MEMBRANE HOMOGENATES
- ALTERATION IN DOPAMINERGIC AND MUSCARINIC CHOLINERGIC RECEPTORS AFTER SUBCHRONIC TREATMENT WITH HALOPERIDOL IN THE DEVELOPING RAT BRAIN
- ONTOGENESIS OF REARING AND STEREOTYPY RESPONSES TO APOMORPHINE IN THE RAT
- Neuronal Apoptosis and Protection : Effects of Nitric Oxide and Endoplasmic Reticulum-Related Proteins(Mitochondria and Neuroprotection)
- SYNTHETIC α-MELANOCYTE-STIMULATING HORMONE AND MOUSE BEHAVIOUR
- THE ONTOGENETIC DEVELOPMENT OF DOPAMINERGIC-CHOLINERGIC INTERACTION IN THE RAT CNS
- The Actions of NO in the Central Nervous System and in Thymocytes
- INTER- AND INTRACELLULAR SIGNALLING SYSTEM INVOLVED IN NEURONAL DEATH
- Developmental change in rearing response to atropine in rats treated with 6-hydroxydopa.
- Effect of reserpine, ouabain and p-chloromercuribenzoate on the release of 5-hydroxytryptamine from rat brain synaptosomes.
- STUDIES ON PLASMA FACTOR INVOLVED IN 5-HYDROXYTRYPTAMINE RELEASE FROM BLOOD PLATELETS BY BACTERIAL ENDOTOXIN:I. PRESENCE OF 5-HYDROXYTRYPTAMINE RELEASING FACTOR IN RABBIT PLASMA AND ITS INTERACTION WITH HEPARIN AND ENDOTOXIN
- STUDIES ON PLASMA FACTOR INVOLVED IN 5-HYDROXYTRYPTAMINE RELEASE FROM BLOOD PLATELETS BY BACTERIAL ENDOTOXIN:III. MECHANISM OF ACTION OF 5-HYDROXYTRYPTAMINE RELEASING FACTOR
- Prostaglandin and norepinephrine metabolism: Effect of indomethacin on prostaglandin synthesis and norepinephrine turnover rate.
- BRAIN SEROTONIN METABOLISM IN LITHIUM TREATED RATS
- Effect of concanavalin A on 5'-nucleotidase activity of rabbit blood platelets.
- Effect of long-term dosing with tiapride on brain dopamine receptors and metabolism in rats. Comparative study with sulpiride and haloperidol.
- Effect of Concanavalin A on Intracellular Calcium Concentration in Single Blood Platelets.
- Effects of repeated administrations of facteur thymique serique(FTS) on biochemical changes related to aging in senescence-accelerated mouse(SAM).
- Clonidine reduces substance P binding in rat spinal cord membrane preparation.
- Active uptake system for substance P carboxy-terminal heptapeptide (5-11) into a fraction from rabbit enriched in glial cells.
- Effect of concanavalin A on serotonin transport into blood platelets: Possible involvement of protein kinase C.
- Selective blockade of dopamine D-1 receptor by SCH 23390 affects dopamine agonist binding to 3H-spiperone labeled D-2 receptors in rat striatum.
- Effects of Bifemelane Hydrochloride, a Brain Function Improver, on Muscarinic Receptors in the CNS of Senescence-Accelerated Mouse.
- Enhancement of (3H)clonidine binding to rat cerebral synaptic membranes by treatment with arachidonic acid, prostaglandin (PG) D2, PGE2 and PGF2.ALPHA..
- Developmental changes in the levels of substrates for cholera toxin-catalyzed and pertussis toxin-catalyzed ADP-ribosylation in rat cardiac cell membranes.
- Specific binding of (3H)WB 4101, (3H)clonidine and (3H)dihydroalprenolol in cerebral cortical membranes in developing, adult and old rats.
- UPTAKE AND STORAGE MECHANISM OF 5-HYDRO-XYTRYPTAMINE IN RABBIT BRAIN STEM AND EFFECT OF RESERPINE
- Tryptophan Inhibits the (3H)Glutamate Uptake into Xenopus Oocytes Injected with Rat Brain mRNA.
- Chronic effects of imipramine and lithium on 5-HT receptor subtypes in rat frontal cortex, hippocampus and choroid plexus: Quantitative receptor autoradiographic analysis.