Alteration of Leptin-Induced STAT3 Activation in the Brain of Senescence-Accelerated Mouse (SAM) P8(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
We used senescence-accelerated mouse prone 8 (SAMP8), a useful model of accelerated aging, to investigate the responsiveness to leptin with aging. The state of leptin-induced STAT3 phosphorylation in the hypothalamus was found to be higher in SAMP8 than in SAMR1, a control mouse showing normal aging, at 14-18 months of age but not at 2 months of age. Moreover, leptin receptor Ob-Rb expression in the hypothalamus was up-regulated in SAMP8. The results indicate that leptin sensitivity increases with aging in the SAM mouse brain.
- 公益社団法人日本薬学会の論文
- 2005-08-01
著者
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野村 靖幸
Yokohama College Of Pharmacy
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OKUMA Yasunobu
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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NOMURA Yasuyuki
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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ONO Atsushi
Department of Neurosurgery, Yokohama City University School of Medicine
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野村 靖幸
北海道大学・大学院薬学研究科医療薬学講座薬理学分野
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野村 靖幸
北海道大学薬学部薬効学講座
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野村 靖幸
北大薬
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Nomura Yasuyuki
Dep. Of Pharmacotherapeutics Yokohama Coll. Of Pharmacy Jpn
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Okuma Y
Hokkaido Univ. Sapporo Jpn
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HOSOI Toru
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Okuma Yasunobu
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Sciences
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Nomura Yasuyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
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Ono Atsushi
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Ono Atsushi
Department Of Neurosurgery Yokohama City University School Of Medicine
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Okuma Yasunobu
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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Hosoi Toru
広島大学
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