Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain

スポンサーリンク

概要

• 論文の詳細を見る

• Neural stem/progenitor cells (NSCs) reside in the subventricular zone (SVZ) and subgranular zone of the hippocampal dentate gyrus in adult mammals. The ubiquitin ligase HRD1 is associated with degradation of amyloid precursor protein and believed to be specifically expressed in neurons and not in astrocytes. We investigated expression of HRD1 using immunohistochemistry and found colocalization of HRD1 with the NSC marker protein nestin and glial fibrillary acidic protein in the NSCs of the SVZ (the SVZ astrocytes) but not in the hippocampus. In the hippocampal dentate gyrus, HRD1 is localized in the nucleus of nestin-positive cells.

• 2011-11-20

著者

• 野村 靖幸

  Yokohama College Of Pharmacy

• Kasuga Masato

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• Ogita Kiyokazu

  Department Of Parmacology Setsunan University

• OKUMA Yasunobu

  Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University

• Kawada Koichi

  Department Of Pharmacology Setsunan University Faculty Of Pharmaceutical Sciences

• Kawada Koichi

  Department Of Mathematics Faculty Of Education Iwate University

• Ogita Kiyokazu

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University

• 野村 靖幸

  北海道大学・大学院薬学研究科医療薬学講座薬理学分野

• 野村 靖幸

  北海道大学薬学部薬効学講座

• Nomura Yasuyuki

  Dep. Of Pharmacotherapeutics Yokohama Coll. Of Pharmacy Jpn

• Fujino Hiromichi

  Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University

• Fujino Hiromichi

  Faculty Of Pharmaceutical Sciences Hokkaido University

• Hamana H

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• Hamana Hiroshi

  Department Of Applied Chemistry Faculty Of Engineering Saitama Institute Of Technology

• Murayama T

  Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University

• Murayama Toshihiko

  Laboratory Of Chemical Pharamacology Graduate School Of Pharmaceutical Sciences Chiba University

• Murayama Toshihiko

  Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ. Jpn

• Nomura Yasuyuki

  Laboratory of Pharmacotherapeutics, Yokohama College of Pharmacy, Japan

• Kaneko Masayuki

  Department Of Dental Radiology Health Sciences University Of Hokkaido

• Okuma Yasunobu

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Sciences

• Nomura Yasuyuki

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University

• Kaneko Masayuki

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science

• Mimori Seisuke

  Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba Institute of Scien

• Okuma Y

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science

• Okuma Yasunobu

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science

• Nomura Yasuyuki

  Laboratory Of Pharmacotherapeutics Yokohama College Of Pharmacy

• Hamana Hiroshi

  Department Of Pharmaceutical Chemistry Faculty Of Pharmaceuticul Sciences Chiba Institute Of Science

• Kawada Koichi

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science

• Kaneko Masayuki

  千葉科学大学

• Hamana Hiroshi

  Dep. Of Pharmaceutical Chemistry Chiba Inst. Of Sci.

• Mimori Seisuke

  Department of Pharmaceutical Chemistry, Chiba Institute of Science

• MIMORI Seisuke

  Department of Pharmaceutical Chemistry, Faculty of Pharmaceuticul Sciences, Chiba Institute of Science

• Kaneko Masayuki

  Department of Cardiology, Cardiovascular Center, Oita Oka Hospital

関連論文

• Mechanism Underlying the Protective Effect of Tempol and Nω-Nitro-L-arginine Methyl Ester on Acoustic Injury: Possible Involvement of c-Jun N-Terminal Kinase Pathway and Connexin26 in the Cochlear Spiral Ligament
• 老化促進モデルマウスSAMP8、SAMP10の記憶障害・情動障害と脳の生化学的異常
• P-12 黄蓍成分 pterocarpan の血管平滑筋細胞増殖能に対する作用
• P-44 老化促進モデルマウス SAMP8 の記憶学習障害に対するハマボウフウの改善効果
• Molecular Pathopharmacology of 5-HT_ Receptors and the RNA Editing in the Brain
• 功労賞受賞 大関正弘氏の業績(紹介)
• 序文
• 衝動性と5HT2A受容体遺伝子多型との関連性 : Go/Nogo 課題を用いた検討
• 学術貢献賞受賞 山内 卓氏の業績
• 薬学部における6年制と4年制学科の共存について
• 小胞体の変性タンパク質処理系を介するニューロン死防御作用
• 小胞体ストレス応答系と神経細胞死制御 : 序文
• 小胞体の変性タンパク質処理系を介するニューロン死防御作用
• 小胞体ストレス応答系と神経細胞死制御 : 序文
• Preconditioning処置は,虚血処置によってもたらされるラット大脳皮質のペヌンブラ領域における神経細胞死をAktの持続的な活性を介して抑制する(生化学)
• サイエンスエッセイ GrayanotoxinとNa〔+〕チャネル研究:電気ウナギに対峙した広島大学での実験余録
• 小胞体ストレス応答性新規HRD1による神経変性疾患関連蛋白質の分解 (生体機能と創薬シンポジウム2004--イオンチャネル機能と細胞障害--創薬を目指して) -- (シンポジウム2 生体機能解析の新展開)
• 生命科学の研究と教育
• 奨励賞受賞 上原 孝氏の業績
• 神経系 NOのニューロン死制御--ミトコンドリアとカスパーゼの関与 (第1土曜特集 NOと病態)
• ニューロン死に対する 4-phenylbutyrate の防御作用機構
• ニューロン死制御機構 : グリア細胞の脳虚血応答因子の関与
• JJP発展のためにご協力を
• Endogenous and Exogenous Glucocorticoids Prevent Trimethyltin From Causing Neuronal Degeneration of the Mouse Brain In Vivo : Involvement of Oxidative Stress Pathways
• Activation of c-Jun N-Terminal Kinase Cascades Is Involved in Part of the Neuronal Degeneration Induced by Trimethyltin in Cortical Neurons of Mice
• Transcriptional Factors in the Cochlea Within the Inner Ear
• CHARACTERIZATION OF Na^+-DEPENDENT BINDING OF [^3H] GLUTAMATE IN CEREBRAL SYNAPTIC MEMBRANES
• Gene Transcription Through Myc Family Members in Eukaryotic Cells
• Enhanced Expression of Glutathione S-Transferase in the Hippocampus Following Acute Treatment With Trimethyltin In Vivo
• Knock-down of Sorcin Induces Up-regulation of MDR1 in HeLa Cells(Molecular and Cell Biology)
• Effects of carvedilol on MDR1-mediated multidrug resistance : comparison with verapamil
• Deficits in learning ability and aging of skin in both strains of senescence-accelerated mouse (SAM) P8 and P10 : neuropathological, neurochemical, histological and pharmacological analysis(Chemical & Pharmacological study)
• Depressive Behavior and Alterations in Receptors for Dopamine and 5-Hydroxytryptamine in the Brain of the Senescence Accelerated Mouse (SAM)-P10
• MDR1 T-129C Polymorphism can be Predictive of Differentiation, and Thereby Prognosis of Colorectal Adenocarcinomas in Japanese(Biopharmacy)
• MDR1, MRP1 and MRP2 Genotypes and In Vitro Chemosensitivity in Japanese Patients with Colorectal Adenocarcinomas
• Different Contribution of CYP2C19 in the in Vitro Metabolism of Three Proton Pump Inhibitors
• COUPLING MECHANISMS OF GLUTAMATE RECEPTOR TO ANION CHANNEL IN SYNAPTIC MEMBRANES
• Endogenous Nitric Oxide Generation Linked to Ryanodine Receptors Activates Cyclic GMP / Protein Kinase G Pathway for Cell Proliferation of Neural Stem/Progenitor Cells Derived From Embryonic Hippocampus
• Pancreatic Arteriovenous MalformationCombined with Portal Thrombosis
• MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer
• MDR1 C3435T Polymorphism Is Predictive of Later Onset of Ulcerative Colitis in Japanese(Biopharmacy)
• Japanese case of hepatitis B virus genotypes C/D hybrid
• FRS-072 PDK-1 is Required for Regulation of Cell Size and Beta-adrenergic Response in the Hearts(Heart Failure Research (M) FRS15,Featured Research Session,The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• S-4 老化促進モデルマウス (SAM) 脳と皮膚の加齢 : 生薬や食素材の抗老化作用研究における有用性
• 中枢神経系とストレス応答蛋白質 : グリア細胞の低酸素/再酸素化に伴うストレス蛋白質誘導機構
• Helicobacter pylori-negative peptic ulcer in Japan : which contributes most to peptic ulcer development, Helicobacter pylori, NSAIDs or stress?
• Effect of Therapeutic Moderate Hypothermia on Multi-drug Resistance Protein 1-Mediated Transepithelial Transport of Drugs
• Comparison of Synthetic DNA Templates with Authentic cDNA Templates in Terms of Quantification by Real-Time Quantitative Reverse Transcription Polymerase Chain Reaction(Analytical Biochemistry)
• Effects of Acid and Lactone Forms of Eight HMG-CoA Reductase Inhibitors on CYP-Mediated Metabolism and MDR1-Mediated Transport
• Role of Hepatic STAT3 in the Regulation of Lipid Metabolism
• Possible Involvement of Membrane Phospholipids in Inhibition by Ferrous Ions of [^3H]MK-801 Binding to the Native N-Methyl-D-Aspartate Channel in Rat Brain
• S5-3 Possible roles of transcription factors in glutamate signaling(SYMPOSIUM 5: PHYSIOLOGY AND DISEASE OF GLUTAMATE IN NEURONAL AND GLIAL CELLS)(Proceedings of the 31st Annual Meeting)
• Effects of Polymorphisms of MDR1, MRP1, and MRP2 Genes on Their mRNA Expression Levels in Duodenal Enterocytes of Healthy Japanese Subjects(Biopharmacy)
• MDR1-Mediated Interaction of Digoxin with Antiarrhythmic or Antianginal Drugs
• Factors Influencing the Prediction of Steady State Concentrations of Digoxin
• Interaction of Docetaxel ("Taxotere") with Human P-Glycoprotein
• P-gp誘導 Caco-2 細胞 : P-gp高感度 Assay System の構築
• 小胞体ストレス応答と神経細胞死制御--細胞分子薬理学的アプローチ (特集:薬学研究)
• 脳神経系の細胞膜受容体応答とストレス応答に関する細胞分子薬理学的研究
• 神経化学会のさらなる活性化と発展を祈って
• NO : 功の助長/罪の克服研究を
• Effects of Various Storage Conditions and Alterations of Antioxidant Contents on Chromatic Aberration of Hydroquinone Ointment(Biopharmacy)
• Effect of Serum Triglyceride Concentration on the Fluctuation of Whole Blood Concentration of Cyclosporin A in Patients
• PROSPECT OF ENDOSCOPIC MUCOSAL RESECTION FOR EARLY GASTRIC CANCER : OUR DEVICES IN INSULATED-TIP ELECTROSURGICAL KNIFE METHOD
• N-Acetyltransferase 2 Genotype-Related Sulfapyridine Acetylation and Its Adverse Events
• Optimal Dose of Omeprazole for CYP2C19 Extensive Metabolizers in Anti-Helicobacter pylori Therapy : Pharmacokinetic Considerations
• ARGON PLASMA COAGULATION FOR TREATMENT OF HEMORRHAGIC RADIATION GASTRODUODENITIS
• N-Acetyltransferase 2 Genotype Correlates with Sulfasarazine Pharmacokinetics after Multiple Dosing in Healthy Japanese Subjects
• Sufficient effect of 1-week omeprazole and amoxicillin dual treatment for Helicobacter pylori eradication in cytochrome P450 2C19 poor metabolizers
• HILA-DQB1 locus and the development of atrophic gastritis with Helicobacter pylori infection
• Pharmaceutical and Clinical Assessment of Hydroquinone Ointment Prepared by Extemporaneous Nonsterile Compounding
• Adult Neurogenesis Is Regulated by Endogenous Factors Produced During Neurodegeneration
• A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.
• PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells
• Alteration of Leptin-Induced STAT3 Activation in the Brain of Senescence-Accelerated Mouse (SAM) P8(Pharmacology)
• Aspirin and Sodium Salicylate Protect Brain Cell Death Against Endoplasmic Reticulum Stress
• Possible Role of Interleukin-6 in PC12 Cell Death Induced by MPP^+ and Tetrahydroisoquinoline
• Cholecystokinin Inhibits Food Intake Independent of Interleukin-1β Expression in the Brain(Pharmacology)
• Pancreatic β Cell Mass Preserved in Heterozygous PDK1 Knockout Mice
• [^3H] GLUTAMATE BINDING IN MEMBRANOUS PREPARATIONS FROM RAT ADRENAL
• Reduced Insulin Signaling and Endoplasmic Reticulum Stress Act Synergistically to Deteriorate Pancreatic β Cell Function
• Novel Functions of Ubiquitin Ligase HRD1 With Transmembrane and Proline-Rich Domains
• A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes
• Manganese Superoxide Dismutase Is Induced by Endoplasmic Reticulum Stress through IRE1-Mediated Nuclear Factor (NF)-κB and AP-1 Activation(Biochemistry/Molecular Biology)
• Activation Signal of Nuclear Factor-κB in Response to Endoplasmic Reticulum Stress is Transduced via IRE1 and Tumor Necrosis Factor Receptor-Associated Factor 2
• Extracellular Signal Regulated Protein Kinase and c-Jun N-Terminal Kinase are Involved in m1 Muscarinic Receptor-Enhanced Interleukin-2 Production Pathway in Jurkat Cells
• TEK/Tie2 Is a Novel Gene Involved in Endoplasmic Reticulum Stress
• グリア細胞のiNos，ケモカイン発現に関わるNF-κB系活性制御と薬物作用
• 細胞膜の受容体 : 基礎知識から最新の情報まで, 東邦大学名誉教授, 高柳一成 編集, B5版, 356頁, 163図, 発行: 株式会社 南山堂, 定価 本体7,000円+税
• ヒトニューロブラストーマSH-SY5Y細胞に対するNOのアポトーシス惹起機構への caspase の関与
• Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain
• Mechanism Underlying the Protective Effect of Tempol and N^ω-Nitro-L-arginine Methyl Ester on Acoustic Injury : Possible Involvement of c-Jun N-Terminal Kinase Pathway and Connexin26 in the Cochlear Spiral Ligament
• Enhanced Expression of Glutathione S-Transferase in the Hippocampus Following Acute Treatment With Trimethyltin In Vivo
• Adult Neurogenesis Is Regulated by Endogenous Factors Produced During Neurodegeneration
• Endogenous Nitric Oxide Generation Linked to Ryanodine Receptors Activates Cyclic GMP/Protein Kinase G Pathway for Cell Proliferation of Neural Stem/Progenitor Cells Derived From Embryonic Hippocampus
• Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase-Mediated Pathway
• Correlation Between Decrease in Protein Levels of Ubiquitin Ligase HRD1 and Amyloid-β Production
• Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer's Disease : Possible Involvement of HRD1, a Novel Molecule Related to Endoplasmic Reticulum Stress, in Alzheimer's Disease
• Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain
• Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells

もっと見る 閉じる

スポンサーリンク