Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain
スポンサーリンク
概要
- 論文の詳細を見る
Neural stem/progenitor cells (NSCs) reside in the subventricular zone (SVZ) and subgranular zone of the hippocampal dentate gyrus in adult mammals. The ubiquitin ligase HRD1 is associated with degradation of amyloid precursor protein and believed to be specifically expressed in neurons and not in astrocytes. We investigated expression of HRD1 using immunohistochemistry and found colocalization of HRD1 with the NSC marker protein nestin and glial fibrillary acidic protein in the NSCs of the SVZ (the SVZ astrocytes) but not in the hippocampus. In the hippocampal dentate gyrus, HRD1 is localized in the nucleus of nestin-positive cells.
- 2011-11-20
著者
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野村 靖幸
Yokohama College Of Pharmacy
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Kasuga Masato
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Ogita Kiyokazu
Department Of Parmacology Setsunan University
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OKUMA Yasunobu
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Kawada Koichi
Department Of Pharmacology Setsunan University Faculty Of Pharmaceutical Sciences
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Kawada Koichi
Department Of Mathematics Faculty Of Education Iwate University
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Ogita Kiyokazu
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University
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野村 靖幸
北海道大学・大学院薬学研究科医療薬学講座薬理学分野
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野村 靖幸
北海道大学薬学部薬効学講座
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Nomura Yasuyuki
Dep. Of Pharmacotherapeutics Yokohama Coll. Of Pharmacy Jpn
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Fujino Hiromichi
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
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Fujino Hiromichi
Faculty Of Pharmaceutical Sciences Hokkaido University
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Hamana H
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Hamana Hiroshi
Department Of Applied Chemistry Faculty Of Engineering Saitama Institute Of Technology
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Murayama T
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
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Murayama Toshihiko
Laboratory Of Chemical Pharamacology Graduate School Of Pharmaceutical Sciences Chiba University
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Murayama Toshihiko
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ. Jpn
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Nomura Yasuyuki
Laboratory of Pharmacotherapeutics, Yokohama College of Pharmacy, Japan
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Kaneko Masayuki
Department Of Dental Radiology Health Sciences University Of Hokkaido
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Okuma Yasunobu
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Sciences
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Nomura Yasuyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
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Kaneko Masayuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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Mimori Seisuke
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba Institute of Scien
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Okuma Y
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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Okuma Yasunobu
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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Nomura Yasuyuki
Laboratory Of Pharmacotherapeutics Yokohama College Of Pharmacy
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Hamana Hiroshi
Department Of Pharmaceutical Chemistry Faculty Of Pharmaceuticul Sciences Chiba Institute Of Science
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Kawada Koichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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Kaneko Masayuki
千葉科学大学
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Hamana Hiroshi
Dep. Of Pharmaceutical Chemistry Chiba Inst. Of Sci.
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Mimori Seisuke
Department of Pharmaceutical Chemistry, Chiba Institute of Science
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MIMORI Seisuke
Department of Pharmaceutical Chemistry, Faculty of Pharmaceuticul Sciences, Chiba Institute of Science
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Kaneko Masayuki
Department of Cardiology, Cardiovascular Center, Oita Oka Hospital
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