Gene Transcription Through Myc Family Members in Eukaryotic Cells

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概要

• 論文の詳細を見る

• c-Myc family proteins, encoded by c-myc family proto-oncogenes, play critical roles in mechanisms associated with proliferation, differentiation and apoptotic death in eukaryotic cells. These functions are mediated by transcriptional activity of these proteins through binding to the E-box core sequence CACGTG referred to as a Myc core element located at a promoter or enhancer region of the individual target genes in the nucleus. Recent studies have demonstrated the presence of novel nuclear proteins that specifically recognize a Myc core element, in addition to c-Myc, Max, Mad and Mxi1. On the other hand, a Myc core element has alternating purine/pyrimidine repeats which could undergo a conformational transition from right-handed (B-DNA) to left-handed (Z-DNA) forms in the presence of a high concentration of salts such as Mg2+ and polyamines. Similarly, a Myc element has a homopurine-homopyrimidine site that may take a triplex configuration in particular situations. We have searched for nuclear proteins that can specifically recognize a Myc core element in different topological variations in murine brain.

• 社団法人 日本薬理学会の論文
• 1999-06-01

著者

• Ogita Kiyokazu

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Japan

• Ogita Kiyokazu

  Department Of Pharmacology Setsunan University Faculty Of Pharmaceutical Sciences

• Ogita K

  Department Of Pharmacology Setsunan University

• Ogita Kiyokazu

  摂南大学 薬理

• Ogita Kiyokazu

  Department Of Parmacology Setsunan University

• KURAMOTO Nobuyuki

  Department of Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences

• YONEDA YUKIO

  Department of Pharmacology, Setsunan University

• Yoneda Yukio

  摂南大学 薬理

• Yoneda Y

  Department Of Pharmacology Setsunan University

• Yoneda Yukio

  Department Of Molecular Pharmacology Kanazawa University Faculty Of Pharmaceutical Sciences

• Kuramoto Nobuyuki

  Department Of Pharmacology Setsunan University

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