Enhanced Expression of Glutathione S-Transferase in the Hippocampus Following Acute Treatment With Trimethyltin In Vivo
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概要
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We investigated the effects of treatment with trimethyltin (TMT) on the expression of glutathione-related enzymes in mouse hippocampus. TMT promoted the expression of glutathione S-transferase (GST) Ya/Yc mRNA, and GSTA2 protein, but not that of glutamate-cysteine ligase catalytic subunit mRNA, 1 day after injection. TMT produced a slight but significant elevation of GST activity during the period from day 1 to 7 post-treatment. No significant change was seen in the activity of glutathione peroxidase at anytime post-TMT treatment. Our data suggest the prolonged elevation of GST activity in the hippocampus following TMT treatment through enhanced expression of the GST Ya/Yc.
- 社団法人 日本薬理学会の論文
著者
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Huong Nguyen
Department Of Bioproduction Environmental Sciences Faculty Of Agriculture Kyushu University
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Nagashima Reiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Japan
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Ogita Kiyokazu
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Japan
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Nagashima Reiko
Department Of Pharmacology Setsunan University Faculty Of Pharmaceutical Sciences
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Ogita Kiyokazu
Department Of Parmacology Setsunan University
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Sano Shohei
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Japan
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Shiba Tatsuo
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Japan
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Huong Nguyen
Department Of Bioproduction And Environmental Science Faculty Of Agriculture Kyushu University
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Shiba Tatsuo
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University
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Sano Shohei
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University
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Nagashima Reiko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University
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