MDR1, MRP1 and MRP2 Genotypes and In Vitro Chemosensitivity in Japanese Patients with Colorectal Adenocarcinomas

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概要

• 論文の詳細を見る

• In our previous paper, the chemosensitivity of human colorectal adenocarcinoma was evaluated against 12 anticancer drugs including 5-fluorouracil (5-FU), 7-ethyl-10-hydroxycamptothecin (SN-38), mitomycin C (MMC) and cisplatin (CDDP), and it was found that the anticancer drugs were effective against those with a relatively high growth rate. MMC was effective for those with a relatively high mRNA expression of the multidrug resistance-associated protein 2 (MRP2), whereas no correlation was found for the multidrug resistant transporter MDR1 and MRP1. In this study, 3 genotypes of MDR1, 4 genotypes of MRP1, and 6 genotypes of MRP2 were additionally evaluated, and it was suggested that MDR1 C3435T and MRP2 G1249A were related with the susceptibility to colorectal adenocarcinoma. The chemosensitivity against 5-FU, SN-38, MMC and CDDP was independent of MDR1 C3435T, MRP1 G2168A, and MRP2 C-24T (C3972T), possibly due to no association with the growth rate of and mRNA expression levels of MDR1, MRP1 and MRP2 in the adenocarcinoma, however, MDR1 C3435T tended to be accompanied with a higher expression of MDR1 mRNA.

• 神戸大学の論文

著者

• Nakamura T

  Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences

• Kasuga Masato

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• Kuroda Yoshikazu

  神戸大学 医学研究科外科学講座

• Kuroda Y

  Division Of Gastroenterological Surgery Department Of Clinical Molecular Medicine Kobe University Gr

• Kuroda Yoshikazu

  神戸大学 医学系研究科消化器外科学

• Kakumoto M

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• Kamigaki Takashi

  Kobe University Graduate School of Medicine

• Kuroda Yoshikazu

  Kobe University Graduate School of Medicine

• Ku Y

  Department Of Hepato-biliary-pancreatic Surgery Kobe University Graduate School Of Medical Sciences

• Ku Yonson

  Department Of Surgery Kobe University Graduate School Of Medical Sciences

• Ku Yonson

  Surgery Kobe University Graduate School Of Medicine

• Sakai Toshiyuki

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• Kimura T

  Kobe University Graduate School Of Medicine

• Kamigaki T

  Kobe Univ. School Of Medicine Kobe

• Kuroda Yoshikazu

  Division Of Gastroenterological Surgery Department Of Clinical Molecular Medicine Kobe University Gr

• Takara Kohji

  Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University

• Nishioka Chiharu

  Kobe University Graduate School of Medicine

• Sakaeda Toshiyuki

  School of Medicine, Kobe University

• Nakamura Tsutomu

  School of Medicine, Kobe University

• Moriya Yuka

  School of Medicine, Kobe University

• Okamura Noboru

  School of Medicine, Kobe University

• Tamura Takao

  Kobe University Graduate School of Medicine

• Nakahara Takako

  Kobe University Graduate School of Medicine

• Aoyama Nobuo

  School of Medicine, Kobe University

• Ohno Masakazu

  Kobe University Graduate School of Medicine

• Kasuga Masato

  Kobe University Graduate School of Medicine

• Okumura Katsuhiko

  School of Medicine, Kobe University

• Nakajima Takahiro

  Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences

• Okumura K

  Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine

• Moriya Yuka

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• Tamura T

  Division Of Diabetes Digestive And Kidney Diseases Department Of Clinical Molecular Medicine Kobe Un

• Aoyama Nobuo

  Department Of Endoscopy School Of Medicine Kobe University

• Takara Kohji

  Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University

• Takara Kohji

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• Ohmoto Nobuko

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• Okamura N

  Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine

• Okamura Noboru

  School Of Allied Health Sciences Tokyo Medical And Dental University

• Okamura Noboru

  School Of Allied Health Sciences Faculty Of Medicine Tokyo Medical And Dental University

• Shirakawa T

  Kobe University School Of Medicine

• Shirakawa Toshiro

  Department Of Urology Kobe University School Of Medicine

• Okumura Katsuhiko

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• Kuroda Yoshikazu

  First Department Of Surgery Faculty Of Medicine Kobe University

• Ku Yonson

  Department Of Gastroenterological Surgery Kobe University Graduate School Of Medicine

• Okumura Katsuhiko

  Department Of Hospital Pharmacy Kyoto Pharmaceutical University:department Of Hospital Pharmacy Kobe

• Nakamura Takeshi

  Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences

• Nakamura T

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• Sakai T

  Department Of Internal Medicine And Gastrointestinal Endoscopy Saga Medical School

• Aoyama Nobuo

  Second Department Of Internal Medicine Kobe University School Of Medicine

• Okamura N

  Shionogi & Co. Ltd. Toyonaka Jpn

• Koishi Tomokazu

  Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University

• Nakamura Takatoshi

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Kaneko M

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science

• Kaneko Masayuki

  千葉科学大学

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