A Multi-institutional Study on Adjuvant Chemotherapy for the Prevention of Post-operative Liver Metastases in Colorectal Cancer Patients : Comparison Between Hepatic Arterial and Portal Adriamycin Plus Oral UFT Administration

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概要

• 論文の詳細を見る

• In order to clarify which is more effective for the prevention of post-operative liver metastases in colorectal cancer patients, adjuvant chemotherapy consisting of hepatic arterial or intra-portal adriamycin (ADM) plus oral UFT administration was examined as an open trial of multi-institutions. Patients were given ADM 20 mg/m^2 via the hepatic artery in intra-arterial group (IA group) and the portal vein in intra-portal. Group (IP group) just after the resection of cancer lesions, respectively. Thereafter, all of the patients were orally treated with UFT 270 mg/ m^2/day for 2 years. Forty-five colorectal cancer patients with curability A and B, 12 patients in the IA group and 33 in the IP group, were enrolled in the study. No statistical difference was found in 12 clinicopathological variables between the groups. Five-year survival rate was 80.8% in the IA group and 89.9% in the IP group. Although various types of post-operative metastases were found in 25.0% in the former and 21.2% in the latter, the liver metastasis was not found in the IA group. The metastasis was found in 5 patients of the IP group. There was no statistical difference in the survival and liver metastatic curves or rates between the groups. These results suggest that the intra-arterial adjuvant chemotherapy for colorectal cancer patients is not beneficial to the prophylaxis of post-operative liver metastases, in comparison with the intra-portal chemotherapy.

• 神戸大学の論文
• 2001-11-30

著者

• KURODA Yoshikazu

  First Division, Department of Surgery, Kobe University School of Medicine

• Nakamura T

  Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences

• Kuroda Y

  Department Of Surgery Kobe University Graduate School Of Medicine

• Kuroda Yoshikazu

  神戸大学 医学研究科外科学講座

• Kuroda Y

  Division Of Gastroenterological Surgery Department Of Clinical Molecular Medicine Kobe University Gr

• Kuroda Yoshikazu

  神戸大学 医学系研究科消化器外科学

• Kamigaki Takashi

  Kobe University Graduate School of Medicine

• NAKAMURA Takeshi

  First Department of Surgery, Kobe University School of Medicine

• Ku Y

  Department Of Hepato-biliary-pancreatic Surgery Kobe University Graduate School Of Medical Sciences

• Ku Yonson

  Department Of Surgery Kobe University Graduate School Of Medical Sciences

• Ku Yonson

  Surgery Kobe University Graduate School Of Medicine

• Kimura T

  Kobe University Graduate School Of Medicine

• Kamigaki T

  Kobe Univ. School Of Medicine Kobe

• Kamigaki Takashi

  First Department Of Surgery Kobe University School Of Medicine

• Kamigaki Takashi

  神戸大学 第1外科

• Kuroda Yoshikazu

  Division Of Gastroenterological Surgery Department Of Clinical Molecular Medicine Kobe University Gr

• Ohno Masakazu

  Kobe University Graduate School of Medicine

• Tabuchi Yoshiki

  Faculty of Health Sciences, Kobe University School of Medicine

• Ohno Masakazu

  First Department of Surgery, Kobe University School of Medicine

• Takara Kohji

  Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University

• Takara Kohji

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• Okumura Katsuhiko

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• Kuroda Yoshikazu

  First Department Of Surgery Faculty Of Medicine Kobe University

• Ku Yonson

  Department Of Gastroenterological Surgery Kobe University Graduate School Of Medicine

• Okumura Katsuhiko

  Department Of Hospital Pharmacy Kyoto Pharmaceutical University:department Of Hospital Pharmacy Kobe

• Ohno Masakazu

  First Department Of Surgery Kobe University School Of Medicine

• Nakamura Takeshi

  Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences

• Nakamura Takeshi

  First Department Of Surgery Kobe University School Of Medicine

• Nakamura T

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• Tabuchi Yoshiki

  Faculty Of Health Sciences Kobe University School Of Medicine

• Tabuchi Yoshiki

  Faculty Of Health Science Kobe University School Of Medicine

• Koishi Tomokazu

  Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University

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