Reversal Effects of Ca2+ Antagonists on Multidrug Resistance via Down-regulation of MDR1 mRNA
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概要
- 論文の詳細を見る
In previous reports, the effects of 12 Ca2+ antagonists on a multidrug resistanttransporter, P-glycoprotein/MDR1, were evaluated in terms of those onMDR1-mediated transport of [3H]digoxin and the sensitivity of vinblastine sulfate orpaclitaxel, and they were able to be classified into 4 subgroups based on their actions,as those with transport inhibition and sensitivity recovery, those with or withouttransport inhibition but marginal sensitivity recovery, and those without both. Inthis study, our previous findings were confirmed by the resistance against doxorubicinhydrochloride and daunorubicin hydrochloride, and by the recovery of [3H] vinblastinesulfate accumulation. Furthermore, it was found that the effects of 12 Ca2+antagonists on the sensitivity recovery were also explained by the down-regulation ofMDR1 mRNA, suggesting a novel mechanism to reverse the MDR1-mediatedmultidrug resistance.
- 神戸大学の論文
著者
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TANIGAWARA Yusuke
Department of Pharmacy, School of Medicine, Keio University
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谷川原 祐介
慶應義塾大学病院薬剤部
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Nakamura T
Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences
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谷川原 祐介
慶応義塾大学薬剤部
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NAKAMURA Tsutomu
Department of Hospital Pharmacy, Kobe University School of Medicine
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YAMAMORI Motohiro
Department of Hospital Pharmacy, Kobe University School of Medicine
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OKAMURA Noboru
Department of Clinical Evaluation of Pharmacotherapy, Kobe University Graduate School of Medicine
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OKUMURA Katsuhiko
Department of Hospital Pharmacy, Kobe University School of Medicine
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Sakaeda Toshiyuki
Center for Integrative Education of Pharmacy Frontier (Frontier EDucation Center)
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Sakai Toshiyuki
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Sakaeda Toshiyuki
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Sakaeda Toshiyuki
筑波大学 人間総合科学研究科
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Kimura T
Kobe University Graduate School Of Medicine
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谷川原 祐介
慶応義塾大学 薬剤部
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谷川原 祐介
大日本製薬薬物動態研究所
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Kobayashi H
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Komoto Chiho
Department of Hospital Pharmacy, School of Medicine, Kobe University
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Ohmoto Nobuko
Department of Hospital Pharmacy, School of Medicine, Kobe University
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Kobayashi Hironao
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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Kuwahara Akiko
Department of Hospital Pharmacy, School of Medicine, Kobe University
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Nishiguchi Kohshi
Department of Hospital Pharmacy, School of Medicine, Kobe University
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Takara Kohji
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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Nakajima Takahiro
Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences
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Okumura K
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Komoto Chiho
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Takara Kohji
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Takara Kohji
Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Takara Kohji
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Ohmoto Nobuko
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Okamura N
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Okamura Noboru
School Of Allied Health Sciences Tokyo Medical And Dental University
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Kuwahara Akiko
Department Of Hospital Pharmacy Kobe University School Of Medicine
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Shirakawa T
Kobe University School Of Medicine
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Shirakawa Toshiro
Department Of Urology Kobe University School Of Medicine
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Yamamori Motohiro
Kobe Univ. Hospital Kobe Jpn
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Yamamori Motohiro
Department Of Hospital Pharmacy Kobe University Hospital
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Yamamori Motohiro
Department Of Clinical Pharmacy Kobe Pharmaceutical University
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Tanigawara Yusuke
Department Of Clinical Pharmacokinetics And Pharmacodynamics School Of Medicine Keio University
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Tanigawara Yusuke
Department Of Pharmacy Kobe University Hospital
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Nishiguchi K
Department Of Hospital Pharmacy Kobe University School Of Medicine
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Nishiguchi Kohshi
Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Nishiguchi Kohshi
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Okumura Katsuhiko
Department Of Hospital Pharmacy School Of Medicine Kobe University
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谷川原 祐介
慶應義塾大学医学部臨床薬剤学
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Kobayashi Hironao
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Okumura Katsuhiko
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Okumura Katsuhiko
Department Of Hospital Pharmacy Kyoto Pharmaceutical University:department Of Hospital Pharmacy Kobe
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Okamura Noboru
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Nakamura Tsutomu
Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences
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Nakamura Takeshi
Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences
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Nakamura T
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Sakai T
Department Of Internal Medicine And Gastrointestinal Endoscopy Saga Medical School
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Nagahiro Kazumi
Department Of Hospital Pharmacy Kobe University School Of Medicine
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Okamura N
Shionogi & Co. Ltd. Toyonaka Jpn
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Koishi Tomokazu
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Nakamura Takatoshi
Faculty Of Pharmaceutical Sciences Nagoya City University
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Nakamura Tsutomu
Department Of Chemistry Nara Womens University
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八木 麻理子
Department of Clinical Evaluation of Pharmacotherapy, Kobe University Graduate School of Medicine
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八木 麻理子
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Yamamori Motohiro
Department Of Clinical Pharmacy School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's
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Nakamura Tsutomu
Department Of Chemistry Faculty Of Science Faculty Of Agriculture Kyoto Unviersity
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Sakaeda Toshiyuki
Center for Integrative Education in Pharmacy and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University
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SAKAEDA Toshiyuki
Center for Development of Integrative Education in Pharmacy and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences
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