Intraperitoneal Administration of Oxygenated Perfluorochemical Inhibits Bacterial Translocation Associated with Severe Acute Pancreatitis
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概要
- 論文の詳細を見る
Bacterial translocation from gut has been assumed to be an infectious source in severe acute pancreatitis. The purpose of this study was to test the effect of intraperitoneal administration of oxygenated perfluorochemical on bacterial translocation associated with rat experimental acute necrotizing pancreatitis. Severe necrotizing pancreatitis was induced by retrograde injection of 3% sodium deoxycholate into the biliopancreatic ducts of male Wistar rats. Although mortality rate was not improved by the treatment, intraperitoneal administration of oxygenated perfluorochemical, perfulorodecalin reduced incidence of bacterial translocation to the mesenteric lymph nodes from 60% to 37% 12 hours after development of pancreatitis, and significantly reduced number of bacterial colonies detected after 24 hours. The treatment did not alter the villous height and crypt depth of the ileum. In this model for pancreatitis, however, accelerated apoptosis of the intestinal epithelium was detected histochemically by TUNEL staining and biochemically by DNA fragmentation ELISA, and the apoptotic changes were significantly suppressed by the treatment. These results indicate that intraperitoneal administration of oxygenated perfluorochemical inhibits apoptosis of intestinal epithelium and bacterial translocation induced in severe acute pancreatitis.
- 神戸大学の論文
著者
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Matsumoto Shin-ichi
First Department Of Surgery Kobe University School Of Medicine
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Ueda T
Department Of Surgery Kinki University School Of Medicine
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Shinzeki Makoto
神戸大学医学系研究科
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Takeyama Yoshifumi
神戸大学医学系研究科
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Ueda Takashi
神戸大学医学系研究科
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Yasuda Takeo
神戸大学医学系研究科
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Kishi Shinji
神戸大学医学系研究科
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Kuroda Yoshikazu
神戸大学医学系研究科
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SHINKAI MASAYUKI
First Department of Surgery Kobe University School of Medicine
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Shinzeki Makoto
Department Of Surgery Kobe University Graduate School Of Medicine
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Shinzeki Makoto
神戸大学 医学研究科外科学講座
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Kuroda Y
Department Of Surgery Kobe University Graduate School Of Medicine
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Kuroda Yoshikazu
神戸大学 医学研究科外科学講座
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Kuroda Y
Division Of Gastroenterological Surgery Department Of Clinical Molecular Medicine Kobe University Gr
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Takeyama Y
Department Of Surgery Kinki University School Of Medicine
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Ku Y
Department Of Hepato-biliary-pancreatic Surgery Kobe University Graduate School Of Medical Sciences
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Ku Yonson
Surgery Kobe University Graduate School Of Medicine
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Takeyama Yoshifumi
Department Of Surgery School Of Medicine Kinki University
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Kuroda Yoshikazu
Division Of Gastroenterological Surgery Department Of Clinical Molecular Medicine Kobe University Gr
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Kuroda Yoshikazu
First Department Of Surgery Faculty Of Medicine Kobe University
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Ku Yonson
Department Of Gastroenterological Surgery Kobe University Graduate School Of Medicine
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Samizo Masahiro
First Department Of Surgery Kobe University School Of Medicine
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