Immunohistochemical P 53 Protein Expression in Advanced Colorectal Cancer Lesions : No Association with Prognostic Variables or Survival

概要

論文の詳細を見る
Correlations of p 53 protein expression in cancer lesions with the already confirmed 13 prognostic variables and survival were examined in 52 advanced (T 2-4) colorectal cancer patients, because the clinical roles of the expression in the cancer lesions remain controversial. The immunohistochemical p 53 protein expression was found in 28 lesions (positive lesions) but not found in 24 lesions (negative lesions). No significant difference between the positive and negative lesions was found in 11 clinicopathologic variables. The carcinoembryonic antigen (CEA) levels (6.7 ± 11.5 and 13.2 ± 18.1 ng/ml) of peripheral and draining venous blood and argyrophilic nucleolar organizer regions (AgNOR) score (3.21 ± 1.21 per nucleus) of the cancer cells in the positive lesions were not significantly different from those (25.1 ± 64.5 and 46.4 ± 114.2 ng/ml, and 3.52 ± 1.10 per nucleus, respectively) in the negative lesions. In addition, no significant difference was also found in the survival curves or the 5-year survival rates of the patients with positive and negative lesions. From these results, it may be concluded that the p 53 protein expression is not associated with the prognostic variables and the prognosis of advanced colorectal cancer patients.
神戸大学の論文
1999-12-26