Plasma Postheparin Diamine Oxidase Activity after Major Abdominal Surgery

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概要

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• Plasma diamine oxidase (DAO) activity after heparin injection, a circulatory marker for the intestinal mucosal integrity, was evaluated shortly after major abdominal surgery. DAO activity was measured by high-performance liquid chromatography method after 50 units/kg of heparin injection after esophagectomy in 8 patients, total gastrectomy in 16 patients, and pancreatectomy in 7 patients. Blood samples were collected before and at 2, 10, and 30 days after operation. Postheparin DAO activity at the 2nd day after operation decreased to 60% of the value before operation (p<0.05), then recovered gradually until the 30th day. The activity decreased in cases after esophagectomy and pancreatectomy (p<0.01). It is suggested that the intestinal mucosal integrity decreases in the early course after the major gastroenterological surgery.

• 1997-12-26

著者

• YAMAMOTO Masahiro

  First Department of Surgery, Faculty of Medicine, Kobe University

• Tabuchi Yoshiki

  Faculty of Health Sciences, Kobe University School of Medicine

• Kasahara Hiroshi

  First Department Of Surgery Kobe University School Of Medicine

• Usami Makoto

  Division Of Pharmacology Biological Safety Research Center National Institute Of Health Sciences

• Usami Makoto

  Faculty Of Health Science Kobe University School Of Medicine

• Usami M

  Division Of Pathology National Institute Of Health Sciences

• Haji Seiji

  First Department of Surgery, Kobe University School of Medicine

• Haji Seiji

  First Department Of Surgery Kobe University School Of Medicine

• Tabuchi Yoshiki

  Faculty Of Health Sciences Kobe University School Of Medicine

• Tabuchi Yoshiki

  Faculty Of Health Science Kobe University School Of Medicine

• Imamura Ikuo

  Department Of Public Health Osaka City University

• Sakata Kazuya

  First Department of Surgery, Kobe University School of Medicine

• Sakata Kazuya

  First Department Of Surgery Kobe University School Of Medicine

• Yamamoto Masahiro

  First Department Of Surgery Kobe University School Of Medicine

• Yamamoto Masahiro

  First Department Of Surgery Faculty Of Medicine Kobe University

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