Synthetic Lipid A Produces Antitumor Effect in a Hamster Pancreatic Carcinoma Model through Production of Tumor Necrosis Factor from Activated Macrophages

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概要

• 論文の詳細を見る

• The antitumor effect and biological activities of a newly synthesized lipid A analogue (ONO-4007) were investigated in a hamster pancreatic carcinoma model. Marked and dose-dependent inhibition of tumor growth was achieved by i.p. injection twice a week for 3 weeks of 10, 30 or 50 mg/kg of ONO-4007. Endogenous tumor necrosis factor (TNF) activities induced by ONO-4007 were significantly greater in tumor than in serum, spleen and liver. TNF production by macrophages stimulated with ONO-4007 after culture was much greater when culture was performed in the presence of hamster pancreatic carcinoma cells (no cell-to-cell contact). It was further found that the cytotoxic activity of TNF secreted by macrophages cultured with cancer cells was inhibited in the presence of anti-TNF neutralizing antibodies. These findings suggest that ONO-4007 displays antitumor effects by stimulating production of endogenous TNF in tumor macrophages, possibly through activation by soluble macrophage-stimulating factors in cancer cells.

• 神戸大学の論文

著者

• YAMAMOTO Masahiro

  First Department of Surgery, Faculty of Medicine, Kobe University

• Kamigaki Takashi

  Kobe University Graduate School of Medicine

• Kamigaki T

  Kobe Univ. School Of Medicine Kobe

• Kamigaki Takashi

  First Department Of Surgery Kobe University School Of Medicine

• Kamigaki Takashi

  神戸大学 第1外科

• SAITOH Yoichi

  First Department of Surgery, Kobe University School of Medicine

• Yamamoto M

  Kobe Univ. School Of Medicine

• Saitoh Yoichi

  First Department Of Surgery Kobe University School Of Medicine

• Saitoh Y

  Kobe Univ. School Of Medicine

• Morita Yasushi

  First Department Of Surgery Faculty Of Medicine Kobe University

• Morita Shinsuke

  First Division,Department of Surgery,Kobe University School of Medicine

• Saitoh Y

  Kobe Univ. School Of Medicine Kobe Jpn

• Morita Shinsuke

  First Division Department Of Surgery Kobe University School Of Medicine

• Yamamoto Masahiro

  First Department Of Surgery Kobe University School Of Medicine

• Yamamoto Masahiro

  First Department Of Surgery Faculty Of Medicine Kobe University

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