Clinical Significance of Telomerase Activity in Hepatocellular Carcinoma

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概要

• 論文の詳細を見る

• Telomerase is a ribonucleoprotein enzyme that elongates telomeric DNA. It has been reported that most immortal cell lines express telomerase, whereas in adult normal tissues telomerase activity is not detected. So, in malignant tumors telomerase is thought to be activated to maintain their immortality. In this study, we examined telomerase activity in 12 cases of hepatocellular carcinoma (HCC) with the use of PCR-based assay and analyzed the relationship of telomerase activity to clinicopathological features. In 11 of 12 HCC nodules telomerase activity was detected, of which 9 cases showed strong activity. There was no significant correlation between telomerase activity and clinicopathological features of HCC. Telomerase activity among 6 well-differentiated HCCs was strong in 3 (50%), weak in 2 (33%), and undetected in 1 (17%). All of 6 moderately-differentiated HCCs (100%), however, showed strong activity. As regards tumor size, 4 of 5 HCCs (80%) less than 3 cm in diameter showed strong telomerase activity. On the other hand, weak telomerase activity was detected in only 2 of 12 (17%) noncancerous liver tissues surrounding HCC nodules. The assay of telomerase activity may be a useful diagnostic marker of HCC regardless of tumor size, and the activity may be expressed even at early stage.

• 神戸大学の論文

著者

• KANAMARU Taichi

  First Department of Surgery, Faculty of Medicine, Kobe University

• YAMAMOTO Masahiro

  First Department of Surgery, Faculty of Medicine, Kobe University

• OHTA Kyosuke

  First Department of Surger,y Kobe University School of Medicine

• Ohta Kyosuke

  First Department Of Surger Y Kobe University School Of Medicine

• Ohta Kyosuke

  神戸大学 第1外科

• SAITOH Yoichi

  First Department of Surgery, Kobe University School of Medicine

• Yamamoto M

  Kobe Univ. School Of Medicine

• Saitoh Yoichi

  First Department Of Surgery Kobe University School Of Medicine

• Morita Yasushi

  First Department Of Surgery Faculty Of Medicine Kobe University

• Kanamaru Taichi

  First Department Of Surgery Faculty Of Medicine Kobe University

• Yamamoto Masahiro

  First Department Of Surgery Kobe University School Of Medicine

• Yamamoto Masahiro

  First Department Of Surgery Faculty Of Medicine Kobe University

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