Proliferative Activity of Colorectal Cancer Cells Representing by Proliferating Cell Nuclear Antigen (PCNA) : a Clinical Role
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概要
- 論文の詳細を見る
Relations of the proliferative activity of cancer cells to 13 clinicopathologic variables of cancer lesions and postoperative survival were examined in 57 colorectal cancer patients. The proliferative activity was determined by proliferating cell nuclear antigen (PCNA) labeling indices (LIs) in the primary cancer lesions, and the patients were classified into 2 groups by the mean (49.4 %) of PCNA LIs in all the lesions: 31 patients with high LIs over the mean (high PCNA group) and 26 patients with low LIs under the mean (low PCNA group). Three variables including deep cancer invasion, liver metastasis and advanced stages were significantly more frequently found in the high PCNA group than in the low PCNA group. However, no significant difference was found in the other 10 variables. Survival curve was significantly better in the low PCNA group than in the high PCNA group, and the 3 year-survival rate was 92.4 % in the former and 48.2 % in the latter. The results suggest that the proliferative activity of cancer cells in the primary lesions strongly affects the cancer progression and that the determination of proliferative activity representing by PCNA LIs of cancer cells is clinically useful for the evaluation of survival and/or prognosis in colorectal cancer patients.
- 神戸大学の論文
- 1997-01-24
著者
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NAKAMURA Takeshi
First Department of Surgery, Kobe University School of Medicine
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Tabuchi Yoshiki
Faculty of Health Sciences, Kobe University School of Medicine
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Nakamura Takeshi
Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences
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Nakamura Takeshi
First Department Of Surgery Kobe University School Of Medicine
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NAKAE Shiro
First Department of Surgery, Kobe University School of Medicine
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Nakae Shiro
First Department Of Surgery Kobe University School Of Medicine
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Tabuchi Yoshiki
Faculty Of Health Sciences Kobe University School Of Medicine
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Tabuchi Yoshiki
Faculty Of Health Science Kobe University School Of Medicine
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