In Vivo Effect of Nucleotide and Nucleosides (OG-VI) Solution and Dietary Nucleotide Deficiency on Tumor Proliferation With Coadministration of 5-Fluorouracil (5 FU)

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Aim : To evaluate the effect of nucleotide and nucleosides mixture solution administration on tumor cell proliferation. Methods : Tumor growth of Yoshida sarcoma, inoculated subcutaneously, was evaluated in male Donryu rats under a nucleotide deficient diet with or without intragastric administration of 5-FU (20 mg/kg/day, 7 days) and intraperitoneal administration of OG-VI solution (a mixture of inosine, 5'-GMP, cytidine, uridine, and thymidine in a 4 : 4 : 4 : 3 : 1 molar ratio, 2.8-14 ml/kg/day, 7 days). Results : Tumor weight was 0.50 ± 0.39, 0.13 ± 0.13, and 0.00 ± 0.00 g, in 0, 2.8, and 14 ml/kg/day OG-VI with 5-FU administration, respectively with statistical significance (p < 0.01). Tumor size in dietary nucleotide deficiency rats with OG-VI and 5-FU was 0.13 ± 0.13, against 0.64 ± 0.53 g in a normal diet (p < 0.01). These results were obtained without major complications. The effect of OG-VI mixture was stronger than the effect of each component of OG-VI alone (p < 0.05). Enhancing effect of OG-VI on 5-FU action in tumor proliferation is apparent. Also this pilot study suspects that dietary nucleotide deficiency enhanced the effect of OG-VI. Conclusions : OG-VI is a potential biochemical modulator of 5-FU and dietary nucleotide influences the effect.
神戸大学の論文
1998-12-26