Mutual Relations of Serum Carcinoembryonic Antigen (CEA) Levels to Tumor Volume and Proliferative Activity of Tumor Cells : An Experimental Study

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Carcinoembryonic antigen (CEA) producing tumor, MKN45, cells were transplanted into 15 nude mice, and the mutual relations of serum CEA levels to tumor volume and proliferative activity of tumor cells were analyzed. The proliferative activity was evaluated by proliferating cell nuclear antigen (PCNA) labeling index (LI, %). Respective 2 or 3 mice were sacrificed 1, 2, 3, 4, 5, 6 and 7 weeks after transplantation under etherization. Transplanted tumors grew semi-logarithmically during the experimental period. Correlations represented by the formulas, Y (CEA, ng/ml)=0.002X (tumor volume, mm^3)+1.515 (r=0.745, P<0.01) and Y (log CEA, ng/ml)=0.026X (PCNA LI)-0.26 (r=0.543, P<0.08), were found among serum CEA levels, tumor volume and PCNA LI. A formula, Y (log tumor volume, mm^3)=0.031X (PCNA LI)+2.052 (r=0.582, P<0.06), was found between tumor volume and PCNA LI. The results suggest that serum CEA levels, tumor volume and proliferative activity of tumor cells are mutually correlated in the genetically identical tumors and that the biological malignancy of tumor increases in proportion as tumor grows.
神戸大学の論文
1997-12-26

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