Suppressive Effect of Mitomycin C (MMC) on Liver Recurrence from Gastric VX2 Cancer Lesions
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概要
- 論文の詳細を見る
The suppresive effects of mitomycin C (MMC) on liver recurrence were examined by varying the injection doses and routes in 45 gastric cancer rabbits. The primary cancer lesions without metastasis were resected 14 days after implantation of VX2 cancer, and the animals were autopsied 14 days after resection. Liver recurrence was found in 90 % of control animals, but was not found in animals which received postoperative portal MMC 0.5 and 0.25 mg/Kg and peripheral MMC 1.0 mg/Kg injections. The recurrence rate was significantly higher in the control than in the MMC injected animals. The recurrence was found in 86 and 71% of animals which received postoperative portal MMC 0.125 mg/Kg and peripheral MMC 0.5 mg/Kg injections, respectively. No significant difference was found in the rates between the control and these MMC injected animals. These results suggest that portal MMC injection is more effective for the suppression of liver recurrence than the peripheral injection and that the efficacy dose of the former is almost the same as the 1/4 dose of the latter.
- 神戸大学の論文
- 1994-12-28
著者
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NAKAMURA Takeshi
First Department of Surgery, Kobe University School of Medicine
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Tabuchi Yoshiki
Faculty of Health Sciences, Kobe University School of Medicine
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Nakamura Takeshi
Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences
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Nakamura Takeshi
First Department Of Surgery Kobe University School Of Medicine
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NAKAE Shiro
First Department of Surgery, Kobe University School of Medicine
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Tada Yasuyuki
First Department of Surqery, Kobe University School of Medicine
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Sakane Masayoshi
First Department of Surqery, Kobe University School of Medicine
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Nakae Shiro
First Department Of Surgery Kobe University School Of Medicine
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Tada Yasuyuki
First Department Of Surqery Kobe University School Of Medicine
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Tabuchi Yoshiki
Faculty Of Health Sciences Kobe University School Of Medicine
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Tabuchi Yoshiki
Faculty Of Health Science Kobe University School Of Medicine
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Sakane Masayoshi
First Department Of Surqery Kobe University School Of Medicine
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