Relations of Serum CEA Levels to Clinicopathologic Variables and Proliferating Cell Nuclear Antigen (PCNA) Labeling Indices in Colorectal Cancer
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概要
- 論文の詳細を見る
Relations of serum CEA levels to 13 Clinicopathologic variables of cancer lesions and proliferating cell nuclear antigen (PCNA) labeling indices (LIs) of cancer cells were examined in 57 colorectal center patients. Six variables including deep invasion into the colorectal wall, lymphatic and venous invasion, node metastasis, liver metastasis and advanced stages were more in 28 patients with positive CEA levels (≧5.0 ng/ml) than in 29 patients with negative CEA levels (<5.0 ng/ml). The mean (54.5%) of PCNA LIs in the former was significantly higher than that (44.1%) in the latter. A significant relationship representing by a formura, Y (log CEA, ng/ml)=0.026X (PCNA LI, %) -0.478, was found between CEA levels and PCNA LIs. The results suggest that CEA produced by the cancer cells in the invaded vessels of the primary lesions and by the node and liver metastatic cancer cells enters the draining veins and/or lymphatics in the whole blood. Serum CEA levels is also suggested to increase semilogagarithmically in parallel with the proliferative activity of cancer cells representing by PCNA LIs in the colorectal cancer lesions.
- 神戸大学の論文
- 1997-01-24
著者
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NAKAMURA Takeshi
First Department of Surgery, Kobe University School of Medicine
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Tabuchi Yoshiki
Faculty of Health Sciences, Kobe University School of Medicine
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Nakamura Takeshi
Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences
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Nakamura Takeshi
First Department Of Surgery Kobe University School Of Medicine
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NAKAE Shiro
First Department of Surgery, Kobe University School of Medicine
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Nakae Shiro
First Department Of Surgery Kobe University School Of Medicine
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Tabuchi Yoshiki
Faculty Of Health Sciences Kobe University School Of Medicine
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Tabuchi Yoshiki
Faculty Of Health Science Kobe University School Of Medicine
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