CONFIRMATION STUDY, USING NITROBENZENE, OF THE COMBINED REPEAT DOSE AND REPRODUCTIVE/DEVELOPMENTAL TOXICITY TEST PROTOCOL PROPOSED BY THE ORGANIZATION FOR ECONOMIC COOPERATION AND DEVELOPMENT (OECD)
スポンサーリンク
概要
- 論文の詳細を見る
A confirmatory familiarization study of the Combined Repeat Dose and Reproductive/Developmental Toxicity Screening (ReproTox) test protocol proposed by the Organization for Economic Cooperation and Development (OECD) was performed using nitrobenzene, a testicular toxicant. The agent was given daily by gavage to groups of 10 male and 10 female Sprague-Dawley rats at doses of 100, 60, 20 and 0 mg/kg body weight. Some of the high dose animals exhibited neurological signs, and two males and 9 females died. Hemolytic anemia due to methemoglobin formation was evident in treated males. Histopathologically, treated males showed atrophy of seminiferous tubules of the testis, reactive changes secondary to hemolytic anemia in the hematopoietic organs, and hepatocellular swelling. Cerebral gliosis was observed in middle and high dose males. Male fertility was not affected. The body weights of pups from treated dams were lowered, and their postnatal loss was increased. Most of the known toxicological properties of this chemical was demonstrated in the present study, with the exception of reduced fertility. Therefore, the ReproTox protocol was concluded as being useful as a screening test of existing high production volume chemicals. It should be noted that while the reproductive toxicity test alone is insensitive for detection of male fertility disturbances associated with testicular toxicity, the latter easily be distinguished on morphological grounds.
- 日本トキシコロジー学会の論文
- 1994-08-25
著者
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FURUKAWA Fumio
Division of Pathology, National Institute of Health Sciences
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ONODERA Hiroshi
Division of Pathology, National Institute of Health Sciences
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KODAMA Yukio
Division of Toxicology, National Institute of Health Sciences
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Yasuhara Kazuo
Divisions Of Toxicology National Institute Of Hygienic Sciences
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MITSUMORI Kunitoshi
Division of Pathology, National Institute of Health Sciences
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Takegawa Kiyoshi
Division of Pathology, National Institute of Health Sciences
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Takegawa K
Division Of Pathology National Institute Of Health Sciences:safety Evaluation Drug Development Labor
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Takegawa Kiyoshi
三菱ウェルファーマ
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Takada Koichi
Safety Evaluation Laboratory Yoshitomi Pharmaceutical Industries Co. Ltd.
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Takegawa K
Toxicology Laboratories Pharmaceutical Research Division Mitsubishi Pharma Corporation
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Takegawa Kiyoshi
Department Of Pathology National Institute Of Health Sciences
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Takegawa Kiyoshi
Safety Evaluation Drug Development Laboratories Pharmaceutical Research Division Yoshitomi Pharmaceu
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Hayashi Y
National Inst. Health Sci. Tokyo
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Hayashi Yuzo
Department Of Pharmaceutical Sciences Kitasato University
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KUROKAWA Yuji
Division of Toxicology
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Saito Minoru
Division of Toxicology, National Institute of Health Sciences
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Kawashima Kunio
Division of Toxicology, National Institute of Health Sciences
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Tanaka Satoru
Division of Toxicology, National Institute of Health Sciences
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TAKADA Koichi
Division of Toxicology, Biological Safety Research Center, National Institute of Hygienic Sciences
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TANAKA Satoru
Toxicology Laboratory, Kissei Pharmaceutical Co., Ltd.
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Furukawa Fumio
Division Of Pathology National Institute Of Health Sciences
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Kitamura Y
Division Of Pathology National Institute Of Health Sciences
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Takada Koichi
国立医薬品食品衛生研究所
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Mitsumori Kunitoshi
Division Of Pathology National Institute Of Health Sciences
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Ueda Makoto
Division Of Pathology National Institute Of Health Sciences
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Saito Minoru
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
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Saito Masako
Department Of Applied Physics University Of Tokyo:(present Address)institute For Solid State Physics
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Usami Makoto
Division of Pharmacology, National Institute of Health Sciences
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Kitaura K
Univ. Tokushima School Of Medicine Tokushima
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TAKAHASHI Michihito
Division of Pathology, Biological Safety Research Center, National Institute of Health Sciences
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HAYASHI Yuzo
Biological Safety Research Center, National Institute of Health Sciences
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KAWASHIMA Kunio
National Institute of Health Sciences
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TOYODA Kazuhiro
Division of Pathology
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Uchida Osayuki
Division of Toxicology, Biological Safety Research Center National Institute of Health Sciences
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Hayashi Y
Division Of Pathology National Institute Of Health Sciences
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Tanaka Satoru
Division Of Pharmacology National Institute Of Hygienic Sciences
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Takada Koichi
Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences
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SATO Michio
Div. of Medical Devices National Institute of Hygienic Sciences
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Uchida O
Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences
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Uchida Osayuki
Division Of Toxicology National Institute Of Hygienic Sciences
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Uchida Osayuki
Cellular & Molecular Toxicology Division Biological Safety Research Center National Institute Of
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TOYODA Kazuhiro
Div. of Pathology, NIHS
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NAITO Katsusi
Division of Toxicology, National Institute of Health Sciences
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Toyoda Kazuhiro
Div. Of Pathology Nihs
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Takada Koichi
Dept. Of Toxicology Bioological Safety Research Center National Institute Of Hygienic Sciences
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Takahashi Michihito
Division Of Pathology National Institute Of Health Sciences
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Kodama Yukio
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
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Onodera H
Pharmaceuticals And Medical Devices Agency
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Hayashi Y
Department Of Pharmaceutical Sciences Kitasato University
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Takada Kouichi
Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences
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Takada Koichi
Division Of Pathology National Institute Of Health Sciences:safety Evaluation Drug Development Labor
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Sugi M
Toin Univ. Yokohama Yokohama Jpn
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Hayashi Y
Department Of Pathology Tokyo Metropolitan Komagome Hospital
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Usami Makoto
Division Of Pharmacology Biological Safety Research Center National Institute Of Health Sciences
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Naito Katsushi
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
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Naitoh Katsusi
Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences
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Tanaka S
Toxicology Laboratory Kissei Pharmaceutical Co. Ltd.
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Kobayashi Kazuo
National Institute Of Health Sciences
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Kawashima Kunio
Division Of Pharmacology National Institute Of Hygienic Sciences
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Kawashima Kunio
Division Of Pharmacology Biological Safety Research Center National Institute Of Health Sciences
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Takada Koichi
Divisions Of Toxicology National Institute Of Hygienic Sciences
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Usami M
Division Of Pathology National Institute Of Health Sciences
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Tanaka Satoru
Division Of Internal Medicine Shizuoka City Hospital
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Yasuhara Kazuo
Division Of Medicinal Chemistry And Pharmacognosy Ohio State University
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Takada Koichi
Division Of Toxicology Biological Safety Research Center National Institute Of Hygienic Sciences
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Takada Koichi
吉富製薬福崎安全性研究所
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Usami Makoto
Division Of Pathology National Institute Of Health Sciences
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Naito K
Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences
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Kawashima Kunio
Division Of Biological Evaluation National Institute Of Health Science Osaka Branch
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Tanaka Satoru
Division Of Internal Medicine And Thoracic Surgery Shizuoka City Hospital
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Toyoda Kazuhiro
Division Of Pathology Biological Safety Research Center National Institute Of Health Sciences
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Kobayashi Kazuo
Dept.of Toxicol.tokushima Res.inst.otsuka Pharmaceutical Co. Ltd.
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Hayashi Yuzo
Biological Safety Research Center National Institute Of Hygienic Sciences
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Takayama Satoshi
Research Department Saitama Daiichi Pharmaceutical Co. Ltd. Japanese Pharmaceutical Manufacturers Association
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Takada Koichi
Division Of Pathology National Institute Of Health Sciences
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Usami Makoto
Division of Nutrition and Metabolism, Department of Biophysics, Kobe University Graduate School of Health Sciences
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