NEOPLASTIC AND NON-NEOPLASTIC LESIONS IN AGING Slc : WISTAR RATS
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概要
- 論文の詳細を見る
Spontaneous neoplastic and non-neoplastic lesions in 98 male and 100 female Slc: Wistar rats, which have been widely used in Japan for toxicological studies, were examined. As spontaneous tumors, the most frequent tumors in males were testicular interstitial cell tumors, followed by tumors of the hematopoietic organs, adrenal gland, thyroid gland, preputial gland, pituitary gland, liver and mammary gland. Those in females were tumors of the pituitary gland, mammary gland, hematopoietic organs, uterus and thyroid gland. The organ distribution and histological types of spontaneous tumors observed in Slc: Wistar rats were very similar to those in F-344/DuCrj rats, although the incidences of some tumors differed slightly in the two strains. Various non-neoplastic lesions were also observed in the heart, kidney, liver and many other organs. These results should be useful in evaluating the results of toxicological and carcinogenic studies on this strain of rat.
- 日本トキシコロジー学会の論文
- 1983-11-25
著者
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KODAMA Yukio
Division of Toxicology, National Institute of Health Sciences
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Furuta Kyoko
国立衛生試験所安全性生物試験研究センター病理部
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Furuta Kyoko
国立衛生試験所安全性生物試験研究センター・病理部
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前川 昭彦
国立衛生試験所安全性生物試験研究センター病理部
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ONODERA Hiroshi
国立衛生試験所安全性生物試験研究センター病理部
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TANIGAWA Hiroyuki
国立衛生試験所安全性生物試験研究センター病理部
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HAYASHI Yuzo
国立衛生試験所安全性生物試験研究センター病理部
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前川 昭彦
国立衛生試験所安全性生物試験研究センター
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Kodama Yukio
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
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Kodama Yukio
Division Of Toxicology Biological Safety Research Center National Institute Of Hygienic Sciences
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HORIUCHI Shigetomo
Division of Toxicology, Biological Safety Research Center, National Institute of Hygienic Sciences
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Tanigawa Hiroyuki
国立衛生試験所安全性生物試験研究センター・病理部
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Onodera Hiroshi
国立衛生試験所安全性生物試験研究センター・病理部
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Horiuchi Shigetomo
Division Of Toxicology Biological Safety Research Center National Institute Of Hygienic Sciences
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Hayashi Yuzo
国立衛生試験所安全性生物試験研究センター・病理部
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