TOXICITIES OF MICROENCAPSULATED TRIBROMOMETHANE, DIBROMOCHLOROMETHANE AND BROMODICHLOROMETHANE ADMINISTERED IN THE DIET TO WISTAR RATS FOR ONE MONTH
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概要
- 論文の詳細を見る
The gelatin-starch syrup microencapsulation method was applied to subacute toxicity studies of tribromomethane (TBM), dibromochloromethane (DBCM) and bromodichloromethane (BDCM). Groups of Wistar rats (7 males and 7 females) both sexes were given diet containing microcapsules of each of these trihalomethanes (THMs) at the following concentrations: TBM, 0.068, 0.204 and 0.612% in males, and 0.072, 0.217 and 0.651% in females; DBCM, 0.020, 0.062 and 0.185% in males, and 0.038, 0.113 and 0.338% in females; BDCM, 0.024, 0.072 and 0.215% in males, and 0.024, 0.076 and 0.227% in females. Suppression of body weight gain was seen in each high-dose males fed TBM or BDCM and females fed DBCM or BDCM. Histopathologically, hepatic lesions such as vacuolization and swelling of liver cells were significantly noted in both sexes of all groups fed TBM, in both sexes of the middle- and high-dose groups fed DBCM, and in males of the high-dose group and in females of the middle-and high-dose groups fed BDCM. In addition, single cell necroses were observed in males and females fed DBCM and in males fed BDCM. Hepatic cord abnormalities were also noted in males of the high-dose group fed BDCM. Although no increases in serum transaminase activities (ASAT, ALAT) were evident in either sex fed any of the THMs, decreases in triglyceride content, cholinesterase and lactate dehydrogenase activity were observed. Renal lesions reported to occur in gavage studies were not found in the present feeding study. Lowest-observed-adverse-effect-level (LOAEL) of TBM and no-observed-adverse-effect-level (NOAEL) of DBCM and BDCM were determined to be 56.4 mg/kg, 18.3 mg/kg and 20.6 mg/kg, respectively, under the present experimental conditions.
- 日本トキシコロジー学会の論文
- 1992-08-25
著者
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Yasuhara Kazuo
Divisions Of Toxicology National Institute Of Hygienic Sciences
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Takegawa K
Division Of Pathology National Institute Of Health Sciences:safety Evaluation Drug Development Labor
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Takegawa Kiyoshi
三菱ウェルファーマ
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Takada Koichi
Safety Evaluation Laboratory Yoshitomi Pharmaceutical Industries Co. Ltd.
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Takegawa K
Toxicology Laboratories Pharmaceutical Research Division Mitsubishi Pharma Corporation
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Takegawa Kiyoshi
Department Of Pathology National Institute Of Health Sciences
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KUROKAWA Yuji
Division of Toxicology
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TAKADA Koichi
Division of Toxicology, Biological Safety Research Center, National Institute of Hygienic Sciences
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Kitamura Y
Division Of Pathology National Institute Of Health Sciences
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Takada Koichi
国立医薬品食品衛生研究所
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Uchida Osayuki
Division of Toxicology, Biological Safety Research Center National Institute of Health Sciences
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TOBE Masuo
Division of Toxicology, National Institute of Hygienic Sciences
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安原 加壽雄
Division Of Pathology National Institute Of Health Sciences
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AIDA Yoshitaka
Division of Risk Assessment, Biological Safety Research Center, National Institute of Hygienic Scien
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TOBE Masuo
Natl. Inst. Hyg. Sci.
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Uchida O
Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences
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Uchida Osayuki
Division Of Toxicology National Institute Of Hygienic Sciences
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Uchida Osayuki
Cellular & Molecular Toxicology Division Biological Safety Research Center National Institute Of
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Takada Koichi
Dept. Of Toxicology Bioological Safety Research Center National Institute Of Hygienic Sciences
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Kodama Yukio
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
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Takada Koichi
Division Of Pathology National Institute Of Health Sciences:safety Evaluation Drug Development Labor
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Tobe Masuo
Society Of Japanese Pharmacopeia
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Tobe Masuo
Division Of Toxicology National Institute Of Hygienic Sciences
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Aida Yoshitaka
Division Of Toxicology National Institute Of Health Sciences
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Aida Yoshitaka
Division Of Risk Assessment National Institute Of Health Sciences
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Kawasaki Yasushi
Div.of Toxicol. National Institute Of Health Sciences
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Takada Koichi
Divisions Of Toxicology National Institute Of Hygienic Sciences
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Tobe Masuo
Division Of Toxicology Biological Safety Research Center National Institute Of Hygienic Sciences
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Yasuhara Kazuo
Division Of Medicinal Chemistry And Pharmacognosy Ohio State University
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Aida Yoshitaka
Division Of Toxicology National Institute Of Hygienic Sciences
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Tobe Masuo
Div. Of Toxicol. Biol. Res. Center Natl. Inst. Hygienic Sci.
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Takada Koichi
Division Of Pathology National Institute Of Health Sciences
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