CHRONIC TOXICITY OF MICROENCAPSULATED BROMODICHLOROMETHANE ADMINISTERED IN THE DIET TO WISTAR RATS
スポンサーリンク
概要
- 論文の詳細を見る
A chronic feeding study was carried out in Wistar rats using microencapsulated bromodichloromethane. The test substance was administered in the diet at doses of 0, 0.014, 0.055 and 0.22% for 24 months. Rats were sacrificed after 6, 12, 18 and 24 months of continuous dosing. The results showed a suppression of body weight gain in the 0.22% group for both males and females. Dose related changes were clearly observed in the liver with histopathological findings including fatty degeneration in the 0.014% or higher dose male groups, and fatty degeneration and granuloma in the 0.055 and 0.22% group females, as well as bile duct proliferation and cholangiofibrosis in the 0.22% group for both males and females. No significant differences in incidences or numbers of neoplastic changes were seen between control and any of the treatment groups. There were no dose-related non-neoplastic lesions in the kidneys of either sex. Lowest-observed-adverse-effect-level was determined to be 6.1 mg/kg/day under the present experimental conditions.
- 1992-05-25
著者
-
Yasuhara Kazuo
Divisions Of Toxicology National Institute Of Hygienic Sciences
-
Takegawa K
Division Of Pathology National Institute Of Health Sciences:safety Evaluation Drug Development Labor
-
Takegawa Kiyoshi
三菱ウェルファーマ
-
Takada Koichi
Safety Evaluation Laboratory Yoshitomi Pharmaceutical Industries Co. Ltd.
-
Takegawa K
Toxicology Laboratories Pharmaceutical Research Division Mitsubishi Pharma Corporation
-
Takegawa Kiyoshi
Department Of Pathology National Institute Of Health Sciences
-
KUROKAWA Yuji
Division of Toxicology
-
TAKADA Koichi
Division of Toxicology, Biological Safety Research Center, National Institute of Hygienic Sciences
-
Kitamura Y
Division Of Pathology National Institute Of Health Sciences
-
Takada Koichi
国立医薬品食品衛生研究所
-
TOBE Masuo
Division of Toxicology, National Institute of Hygienic Sciences
-
AIDA Yoshitaka
Division of Risk Assessment, Biological Safety Research Center, National Institute of Hygienic Scien
-
TOBE Masuo
Natl. Inst. Hyg. Sci.
-
Takada Koichi
Dept. Of Toxicology Bioological Safety Research Center National Institute Of Hygienic Sciences
-
Kodama Yukio
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
-
Takada Koichi
Division Of Pathology National Institute Of Health Sciences:safety Evaluation Drug Development Labor
-
Tobe Masuo
Society Of Japanese Pharmacopeia
-
Tobe Masuo
Division Of Toxicology National Institute Of Hygienic Sciences
-
Aida Yoshitaka
Division Of Toxicology National Institute Of Health Sciences
-
Aida Yoshitaka
Division Of Risk Assessment National Institute Of Health Sciences
-
Takada Koichi
Divisions Of Toxicology National Institute Of Hygienic Sciences
-
Tobe Masuo
Division Of Toxicology Biological Safety Research Center National Institute Of Hygienic Sciences
-
Yasuhara Kazuo
Division Of Medicinal Chemistry And Pharmacognosy Ohio State University
-
Aida Yoshitaka
Division Of Toxicology National Institute Of Hygienic Sciences
-
Tobe Masuo
Div. Of Toxicol. Biol. Res. Center Natl. Inst. Hygienic Sci.
-
Takada Koichi
Division Of Pathology National Institute Of Health Sciences
関連論文
- Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
- In vivo mutagenicity and oxidative DNA damage in the livers of gpt delta mice treated with flumequine(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Catechol enhanced mice hepatotoxicity treated with acetaminophen(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- Lack of Initiating Activity of Kojic Acid on Hepatocarcinogenesis in F344 Rats
- Tumorigenic Susceptibility of Catechol on the Gastric Mucosa in rasH2 Mice
- Lack of Modifying Effect of Glycerol in Pulmonary Carcinogenesis in rasH2 Mice Induced by Urethane or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
- LACK OF MODIFYING EFFECTS OF EUGENOL ON DEVELOPMENT OF LUNG PROLIFERATIVE LESIONS INDUCED BY URETHANE IN TRANS-GENIC MICE CARRYING THE HUMAN PROTOTYPE c-Ha-ras GENE
- Lack of Modifying Effects of Cinnamaldehyde on Development of Lung Proliferative Lesions Induced by Urethane in Transgenic Mice Carrying the Human Prototype c-Ha-ras Gene
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Promoting Effects of Ethinylestradiol but not Atrazine on N-ethyl-N-nitrosourea-induced Uterine Carcinogenesis in ICR Mice
- Modifying Effects of 2,6-Dimethylaniline on Nasal Carcinogenesis in RasH2 Mice Initiated with 4-Methylnitrosamino)-1-(3-pyridyl)-1-butanone
- Lack of Modifying Effects of 2,6-Dimethylaniline on Lung Carcinogenesis in Transgenic Mice Carrying Human Prototype c-Ha-ras Gene Initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
- Molecular Pathological Analysis of Apoptosis Induced in Testicular Germ Cells after a Single Administration of Mono-(2-ethylhexyl) phthalate to F344 Rats
- The expression of Ras-related molecules in DMBA-induced forestomach tumors in rasH2 mice(Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- In vitro genotoxic potential and liver initiation activity of ciprofloxacin(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Mechanistic study on hepatocarcinogenesis induced by dicyclanil in mice : possible involvement of oxidative stress(Proceedings of the 32nd Annual Meeting)
- Induction of Hepatocellular Proliferative Lesions in CBA Mice by a 26-week Dietary Administration of Kojic Acid
- Absence of DNA Damage in Comet Assay and Liver Initiation Activity of Cinnamaldehyde
- O-16 Analysis of gene expression profiles of forestomach tumors in rasH2 mice initiated with N-ethyl-N-nitrosourea(ENDOCRINE SYSTEM/DEVELOPMENT AND REPRODUCTION/CARCINOGENICITY/TOXICOGENOMICS)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st
- Modifying Effects of Genistein, 4-Nonylphenol and Methoxychlor on N-ethyl-N-nitrosourea-induced Uterine Carcinogenesis in RasH2 Transgenic Mice Harboring a Human Prototype C-Ha-ras Gene
- Enhancing Effects β-Estradiol 3-Benzoate but Not Methoxychlor on the Promotion/Progression Stage of Chemically-induced Mammary Carcinogenesis in Ovariectomized Rats
- GONADAL TOXICITY OF AN ETHANOL EXTRACT OF PSORALEA CORYLIFOLIA IN A RAT 90-DAY REPEATED DOSE STUDY
- The Utility of N-nitrosamines as Initiators for a 26-Week Rat Two-Stage Nasal Carcinogenesis Model
- "C-1 Reproductive and Developmental Toxicity Studies of Toluene. : II. Effects of inhalation exposure on fertility in rats.
- THE TOXICITY STUDY OF BIODEGRADABLE PLASTIC IN RATS BY DIETARY ADMINISTRATION
- TWENTY-EIGHT-DAY REPEATED DOSE TOXICITY TESTS OF O-NITROTOLUENE IN WISTAR RATS
- 206 A 28-DAY REPEATED INHALATION TOXICITY TEST OF 2,2,3,3,3-PENTAFLUOROPROPANOL IN F344 RAT
- O-16 Analysis of gene expression profiles of forestomach tumors in rasH2 mice initiated with N-ethyl-N-nitrosourea(ENDOCRINE SYSTEM/DEVELOPMENT AND REPRODUCTION/CARCINOGENICITY/TOXICOGENOMICS)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st
- Analysis of Gene Expression Profile on Uterine Tumorigenesis Initiated with N-ethyl-N-nitrosourea and Inhibited by Ethinylestradiol in rasH2 Mice
- THIRTEEN-WEEK REPEATED DOSE TOXICITY OF RICE BRAN GLYCOSPHINGOLIPID IN WISTAR HANNOVER (GALAS) RATS
- THIRTEEN-WEEK REPEATED DOSE TOXICITY STUDY OF WORMWOOD (ARTEMISIA ABSINTHIUM) EXTRACT IN RATS
- Investigation on liver initiation activity and DNA damages of flumequine in mice.(GENERAL SESSION BY ORAL PRESENTATION)(CARCINOGENICITY)
- "C-6 Evaluation of Rat Hepatotoxicity on Benzimidazole Compounds Using Gap Junctional Intercellular Communication Protein, Connexin 32.
- Comparison of the early gene responses of Ahr-activating chemicals using the Percellome system(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- The development of Chemical Toxicogenomics Database by the "Percellome" system for the mechanism-based toxicology(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- Aryl hydrocarbon receptor (AhR) mediated hematotoxicity induced by benzene.(GENERAL SESSION BY ORAL PRESENTATION)(BLOOD SYSTEM & HEMATOLOGY)
- Genome-wide expression analysis of Saccharomyces pastorianus orthologous genes using oligonucleotide microarrays(BIOINFORMATICS)
- Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide
- O-13 Genotoxic potential in vitro and liver initiation activity of norfloxacin(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- O-12 Molecular pathological analyses on hepatocarcinogenesis induced by dicyclanil in mouse two-stage liver carcinogenesis model(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Time Course of Expression of 7,12-Dimethylbenz[a]anthracene-induced CYP1A1 and CYP1B1 mRNA and Protein in Rat Liver
- THYROID PROLIFERATIVE LESIONS INDUCED BY ANTI-THYROID DRUGS IN RATS ARE NOT ALWAYS ACCOMPANIED BY SUSTAINED INCREASES IN SERUM TSH
- TIME COURSE OBSERVATION OF THYROID PROLIFERATIVE LESIONS AND SERUM LEVELS OF RELATED HORMONES IN RATS TREATED WITH KOJIC ACID AFTER DHPN INITIATION
- IMMUNOHISTOCHEMICAL STUDIES OF TSH-PRODUCING CELLS IN THE PITUITARY AND EXPRESSION OF GROWTH FACTORS IN THYROIDAL PROLIF-ERATIVE LESIONS IN RATS TREATED WITH THIOUREA AND EXCESS VITAMIN A
- Enhancement of Skin Tumorigenesis Due to Subcutaneous Implantation of Polyurethane Sheets in Rats Treated with N-Methyl-N-nitrosourea
- "P-42 Protective Effect of Lecithinization-Superoxide Dismutase Against Monocrotaline Induced Lung Injuries
- "P-41 A Morphometric study on the time course change of thyrotroph hypertrophy in the pituitary of rats treated with a goitrogen.
- "P-22 A Combination Toxicity Study of Sodium Ascorbate and Sodium Nitrite In Rats
- ABSENCE OF IN VIVO GENOTOXICITY AND LIVER INITIATION ACTIVITY OF DICYCLANIL
- Effect of CO_2 concentration on the growth and exopolysaccharide production of Bifidobacterium longum cultivated under anaerobic conditions(BIOCHEMICAL ENGINEERING)
- Biological Detoxification of Waste House Wood Hydrolysate Using Ureibacillus thermosphaericus for Bioethanol Production(BIOCHEMICAL ENGINEERING)
- Rational Screening of Antibodies and Design of Sandwich Enzyme Linked Immunosorbant Assay on the Basis of a Kinetic Model(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Strategies for Reducing Supplemental Medium Cost in Bioethanol Production from Waste House Wood Hydrolysate by Ethanologenic Escherichia coli : Inoculum Size Increase and Coculture with Saccharomyces cerevisiae(BIOCHEMICAL ENGINEERING)
- Fed-Batch Coculture of Lactobacillus kefiranofaciens with Saccharomyces cerevisiae for Effective Production of Kefiran(BIOCHEMICAL ENGINEERING)
- Simulation Model for Predicting Limit of Detection and Range of Quantitation of Competitive Enzyme-Linked Immunosorbent Assay(BIOCHEMICAL ENGINEERING)
- Microaeration Enhances Productivity of Bioethanol from Hydrolysate of Waste House Wood Using Ethanologenic Escherichia coli KO11(ENVIRONMENTAL BIOTECHNOLOGY)
- Validation of a Method for Predicting the Precision, Limit of Detection and Range of Quantitation in Competitive ELISA
- New Strategy for Enhancement of Microbial Viability in Simulated Gastric Conditions Based on Display of Starch-Binding Domain on Cell Surface(BIOCHEMICAL ENGINEERING)
- Expression of C-terminal Repeat Region of Peptidoglycan Hydrolase of Lactococcus lactis IL1403 in Methylotrophic Yeast Pichia pastoris(BIOCHEMICAL ENGINEERING)
- Bidirectional Cell-Surface Anchoring Function of C-Terminal Repeat Region of Peptidoglycan Hydrolase of Lactococcus lactis IL1403(BIOCHEMICAL ENGINEERING)
- 3C09-3 Construction of whole cell biocatalysts based on the cell surface adhesive enzymes
- Point Mutations of the c-H-ras Gene in Spontaneous Pulmonary Tumors of Transgenic Mice Carrying the Human c-H-ras Gene
- Genome-Wide Analysis of the Effects of Location and Number of Stress Response Elements on Gene Expression in Saccharovyces cerevisiae(BIOINFORMATICS)
- 313 TUMORIGENESIS OF SUBCUTANEOUS IMPLANTATION OF VARIOUS KINDS OF POLYURETHANE(PU) FILMS IN RATS
- 416 ACUTE AND SUBCHRONIC TOXICITY STUDIES OF 2, 2'-METHYLENEBIS (4-METHYL-6-TERT-BUTYLPHENOL) (MBMBP) IN RATS
- TOXICITIES OF MICROENCAPSULATED TRIBROMOMETHANE, DIBROMOCHLOROMETHANE AND BROMODICHLOROMETHANE ADMINISTERED IN THE DIET TO WISTAR RATS FOR ONE MONTH
- ACUTE AND SUBACUTE TOXICITIES OF THREE TRIHALOMETHANES IN RATS (I)
- DOSE-THRESHOLD FOR THYROID TUMOR-PROMOTING EFFECTS OF ORALLY AMINISTERED KOJIC ACID IN RATS AFTER INITIATION WITH N-bis(2-HYDROXYPROPYL) NITROSAMINE
- CAPACITY FOR INDUCTION OF THYROID PROLIFERATIVE LESIONS BY ANTI-THYROID DRUGS WITH DIFFERENT TOXIC MECHANISMS
- TIME COURSE OBSERVATION OF THYROID PROLIFERATIVE LESIONS AND SERUM TSH LEVELS IN RATS TREATED WITH THIOUREA AFTER DHPN INITIATION
- RELATIONSHIP BETWEEN INDUCTION-DOSES OF THYROID TUMORS BY ANTI-THYROID DRUGS AND PLASMA LEVELS OF T_3, T_4 AND TSH
- The Relationship between Endocrine Imbalance and Alteration of Rat Vaginal Epithelium
- Effects of Reproduction on Spontaneous Development of Endometrial Adenocarcinomas and Mammary Tumors in Donryu Rats
- ACUTE, SUBCHRONIC AND CHRONIC TOXICITY STUDIES OF A SYNTHETIC ANTIOXIDANT, 2,2'-METHYLENEBIS(4-METHYL-6-TERT-BUTYLPHENOL) IN RATS
- O-17 Analysis of expression profile of circadian genes(ENDOCRINE SYSTEM/DEVELOPMENT AND REPRODUCTION/CARCINOGENICITY/TOXICOGENOMICS)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- CHRONIC ORAL TOXICITY STUDY OF A SYNTHETIC ANTIOXIDANT, 2, 2'-METHYLENEBIS(4-ETHYL-6-TERT-BUTYLPHENOL)(MBEBP)IN RATS
- C06 TOXICOLOGICAL STUDY ON 2-(4-MORPHOLINOTHIO)BENZOTHIAZOLE (2-MTBT) IN MICE
- CHRONIC TOXICITY STUDY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) IN MICE
- TOXICITY AND BLOOD CONCENTRATIONS OF XYLAZINE AND ITS METABOLITE, 2, 6-DIMETHYLANILINE, IN RATS AFTER SINGLE OR CONTINUOUS ORAL ADMINISTRATIONS
- Absence of Tumor Promoting Activity of Xylazine in a Two-stage Nasal Carcinogenesis Model in N-bis(2-hydroxypropyl)nitrosamine-treated Rats
- O11-12 Modifying effects of endocrine disrupting chemicals on ENU-induced uterine carcinogenesis in heterozygous p53 deficient CBA mice.
- O-14 Mechanistic studies on testicular toxicity of Psoralea corylifolia extract in rats.(Proceedings of the 27th Annual Meeting)
- Testicular Toxicology of Pubescent and Adult Rats Prenatally Exposure to 3,3',4,4',5-Pentachlorobiphenyl
- 2A-04 Mechanistic study on testicular toxicity in rats caused by nitrofurazone
- CONFIRMATION STUDY, USING NITROBENZENE, OF THE COMBINED REPEAT DOSE AND REPRODUCTIVE/DEVELOPMENTAL TOXICITY TEST PROTOCOL PROPOSED BY THE ORGANIZATION FOR ECONOMIC COOPERATION AND DEVELOPMENT (OECD)
- TOXICITY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) (2ND REPORT) SUBACUTE TOXICITY IN MICE
- MORPHOLOGICAL EVALUATION OF CYCLOPHOSPHAMIDE TESTICULAR TOXICITY IN RATS USING QUANTITATIVE MORPHOMETRY OF SPERMATOGENIC CYCLE STAGES
- TESTICULAR TOXICITY EVALUATION OF CYCLOPHOSPHAMIDE BY QUANTITATIVE MORPHOMETRY OF SPERMATOGENIC CYCLE STAGES
- TOXICITY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) III TRANSFER THROUGH THE MATERNAL MILK AND EFFECT OF 2-MIZ TO THE OFFSPRING MICE
- STUDY OF EXAMINATION METHODS FOR ASSESSING MALE FERTILITY DISTURBANCES 1.QUANTITATIVE MORPHOMETRICAL EVALUATION OF TESTICULAR TOXICITY OF ADRIAMYCIN
- PROBLEMS ON PATHOLOGICAL EXAMINATIONS
- CHRONIC TOXICITY OF MICROENCAPSULATED BROMODICHLOROMETHANE ADMINISTERED IN THE DIET TO WISTAR RATS
- Improvement of L-Lactate Production by CYB2 Gene Disruption in a Recombinant Saccharomyces cerevisiae Strain under Low pH Condition
- Improving protein secretion of a transglutaminase-secreting Corynebacterium glutamicum recombinant strain on the basis of ^C metabolic flux analysis(BIOCHEMICAL ENGINEERING)
- Understanding the mechanism of heat stress tolerance caused by high trehalose accumulation in Saccharomyces cerevisiae using DNA microarray(BIOCHEMICAL ENGINEERING)
- Susceptibility of Heterozygous p53 Deficient CBA Mice to Induction of Liver Proliferative Lesions by Phenobarbital after Dimethylnitrosamine Initiation
- Reporter gene mutation in the livers of gpt delta mice treated with 5-(hydroxymethyl)-2-furfural, a contaminant of various foods
- Modifying Effects of Endocrine Disrupting Chemicals on N-bis (2-hydroxypropyl) Nitrosamine and Sulfadimethoxine-Induced Thyroid Carcinogenesis in Rats
- Modifying Effects of Flumequine on Dimethylnitrosamine-Induced Hepatocarcinogenesis in Heterozygous p53 Deficient CBA Mice
- Lack of Modifying Effects of Bisphenol A and Roasted-Ground Soybean (Kinako) on N-ethyl-N-nitrosourea-Induced Uterine Carcinogenesis in Heterozygous p53 Deficient CBA Mice