The Relationship between Endocrine Imbalance and Alteration of Rat Vaginal Epithelium
スポンサーリンク
概要
- 論文の詳細を見る
The relationship between endocrine imbalance and vaginal epithelial features in rats was examined in aging Donryu and F344 rats, pregnant and lactated Donryu rats, and antipsychotic agent-treated Wistar rats. In addition, the influence of sex steroid hormones and prolactin secretion due to haloperidol administration and pituitary implantation was also investigated in ovariectomized Donryu females. Vaginal cornification and mucification were found to be linked with relatively high 17 β-estradiol (E2) levels and the relatively high progesterone (P) value under higher E2 concentration, respectively. Under ovariectomized conditions, the degree and incidence of vaginal mucification were emphasized by P and E2, being dose-dependency of E2. Mucification of the vaginal epithelium by antipsychotic agents might be induced by high P value through the effect of corpus stimulation by prolactin. These results indicated that the vaginal epithelium of rats is very sensitive to hormonal imbalance, and its morphological features are very useful for the assessment of individual hormone milieu.
- 日本毒性病理学会の論文
- 2002-06-30
著者
-
Takegawa K
Division Of Pathology National Institute Of Health Sciences:safety Evaluation Drug Development Labor
-
Takegawa Kiyoshi
三菱ウェルファーマ
-
Takada Koichi
Safety Evaluation Laboratory Yoshitomi Pharmaceutical Industries Co. Ltd.
-
Takegawa K
Toxicology Laboratories Pharmaceutical Research Division Mitsubishi Pharma Corporation
-
Takegawa Kiyoshi
Toxicology Lab. Mitsubishi Pharm.
-
Takegawa Kiyoshi
Department Of Pathology National Institute Of Health Sciences
-
Takegawa Kiyoshi
Safety Evaluation Drug Development Laboratories Pharmaceutical Research Division Yoshitomi Pharmaceu
-
MAEKAWA Akihiko
Chemical Management Center, National Institute of Technology and Evaluation
-
Takada Koichi
国立医薬品食品衛生研究所
-
MAEKAWA AKIHIKO
Department of Pathology, Sasaki Institute
-
Takada Koichi
Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences
-
Maekawa A
Chemical Management Center National Inst. Of Technol. And Evaluation
-
Maekawa Akihiko
Chemical Management Center National Institute Of Technology And Evaluation
-
Maekawa Akihiko
Department Of Pathology Nagoya City University Medical School
-
NAGAOKA Takaharu
Toxicology Laboratories, Pharmaceutical Research Division, Mitsubishi Pharma Corporation
-
Takada Koichi
Dept. Of Toxicology Bioological Safety Research Center National Institute Of Hygienic Sciences
-
Maekawa Akihiko
Safety Assessment Division Chemical Management Center National Institute Of Technology And Evaluatio
-
Nagaoka Takaharu
Toxicology Laboratories Pharmaceutical Research Division Mitsubishi Pharma Corporation
-
Takada Koichi
Divisions Of Toxicology National Institute Of Hygienic Sciences
-
Takada Koichi
Division Of Toxicology Biological Safety Research Center National Institute Of Hygienic Sciences
関連論文
- P8-29 The left lobe model as an improved mouse pulmonary fibrosis model by intratracheal bleomycin administration(STATISTICAL AND TEST METHODS/LOCAL STIMURATION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- THE TOXICITY STUDY OF BIODEGRADABLE PLASTIC IN RATS BY DIETARY ADMINISTRATION
- 206 A 28-DAY REPEATED INHALATION TOXICITY TEST OF 2,2,3,3,3-PENTAFLUOROPROPANOL IN F344 RAT
- "C-6 Evaluation of Rat Hepatotoxicity on Benzimidazole Compounds Using Gap Junctional Intercellular Communication Protein, Connexin 32.
- Thesaurus for histopathological findings in publically available reports of repeated-dose oral toxicity studies in rats for 156 chemicals
- Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide
- K-Ras Point Mutations in Spontaneously Occurring Endometrial Adenocarcinomas in the Donryu Rat
- α-Naphthylisothiocyanate Induces Intrahepatic Bile Duct with Greater Proliferation in Female Rats than in Males
- Preliminary Evaluation of Toxicologic and Carcinogenic Risks of Copper Gluconate in Rats Given Multiple Carcinogens
- Expression of profiles of cytochrome P450 enzymes in the uterus and liver of female rats treated with indole-3-carbinol(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- α-Smooth Muscle Actin-positive Stromal Cells Reactive to Estrogens Surround Endometrial Glands in Rats but not Mice
- O-11 Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats by increase of cytochrome P450 activities and modulation of estrogen metabolism in the liver(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 3
- Effects of Maternal Exposure to Nonylphenol on Growth and Development of the Female Reproductive System and Uterine Carcinogenesis in Rats
- Effect of neonatal exposure of high dose p-tert octylphenol on the ovary in rats (ENDOCRINE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Carcinogenic risks in the high-risk groups (SYMPOSIUM3: RECENT TOPICS ON THE RISK ASSESSMENT OF CHEMICAL CARCINOGENS) (Proceedings of the 30th Annual Meeting)
- TIME COURSE OBSERVATION OF THYROID PROLIFERATIVE LESIONS AND SERUM LEVELS OF RELATED HORMONES IN RATS TREATED WITH KOJIC ACID AFTER DHPN INITIATION
- IMMUNOHISTOCHEMICAL STUDIES OF TSH-PRODUCING CELLS IN THE PITUITARY AND EXPRESSION OF GROWTH FACTORS IN THYROIDAL PROLIF-ERATIVE LESIONS IN RATS TREATED WITH THIOUREA AND EXCESS VITAMIN A
- Enhancement of Skin Tumorigenesis Due to Subcutaneous Implantation of Polyurethane Sheets in Rats Treated with N-Methyl-N-nitrosourea
- "P-42 Protective Effect of Lecithinization-Superoxide Dismutase Against Monocrotaline Induced Lung Injuries
- "P-41 A Morphometric study on the time course change of thyrotroph hypertrophy in the pituitary of rats treated with a goitrogen.
- "P-22 A Combination Toxicity Study of Sodium Ascorbate and Sodium Nitrite In Rats
- Long-Term Treatment with Bromocriptine Inhibits Endometrial Adenocarcinoma Development in Rats
- Erratum : Thesaurus for histopathological findings in publically available reports of repeated-dose oral toxicity studies in rats for 156 chemicals
- Busulfan胎生期曝露による第一次卵胞減少はDonryuラットの子宮発癌を促進する
- 313 TUMORIGENESIS OF SUBCUTANEOUS IMPLANTATION OF VARIOUS KINDS OF POLYURETHANE(PU) FILMS IN RATS
- 416 ACUTE AND SUBCHRONIC TOXICITY STUDIES OF 2, 2'-METHYLENEBIS (4-METHYL-6-TERT-BUTYLPHENOL) (MBMBP) IN RATS
- TOXICITIES OF MICROENCAPSULATED TRIBROMOMETHANE, DIBROMOCHLOROMETHANE AND BROMODICHLOROMETHANE ADMINISTERED IN THE DIET TO WISTAR RATS FOR ONE MONTH
- ACUTE AND SUBACUTE TOXICITIES OF THREE TRIHALOMETHANES IN RATS (I)
- DOSE-THRESHOLD FOR THYROID TUMOR-PROMOTING EFFECTS OF ORALLY AMINISTERED KOJIC ACID IN RATS AFTER INITIATION WITH N-bis(2-HYDROXYPROPYL) NITROSAMINE
- The Relationship between Endocrine Imbalance and Alteration of Rat Vaginal Epithelium
- Effects of Reproduction on Spontaneous Development of Endometrial Adenocarcinomas and Mammary Tumors in Donryu Rats
- ACUTE, SUBCHRONIC AND CHRONIC TOXICITY STUDIES OF A SYNTHETIC ANTIOXIDANT, 2,2'-METHYLENEBIS(4-METHYL-6-TERT-BUTYLPHENOL) IN RATS
- SEQUENTIAL ALTERATIONS IN CLINICAL BIOCHEMICAL INDICATORS OF RENAL FUNCTION IN 5/6 NEPHRECTOMIZED RATS : BASIC STUDY FOR RENAL TOXICITY USING 5/6 NEPHRECTOMIZED RATS
- Effect of low-dose puromycin on renal function in 5/6 nephrectomized rats
- Renal Toxicity Study Using Five Sixth-nephrectomized Rats : I Changes in toxicity of nephrotoxic substance by treatment-stages after nephrectomy
- CHRONIC ORAL TOXICITY STUDY OF A SYNTHETIC ANTIOXIDANT, 2, 2'-METHYLENEBIS(4-ETHYL-6-TERT-BUTYLPHENOL)(MBEBP)IN RATS
- TOXICITY STUDIES OF A SYNTHETIC ANTIOXIDANT, 2,2'-METHYLENEBIS (4-ETHYL-6-TERT-BUTYLPHENOL) IN RATS 1. ACUTE AND SUBCHRONIC TOXICITY
- B38 COMPARISON OF TOXICITY OF p-DCB IN MALE AND FEMALE RATS
- STUDY ON THE TOXICITY OF 2,2'-METHYLENE-bis(4-ETHYL-6-tert-BUTYLPHENOL) IN RAT (NO.1)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 6)2-AND 4-WEEKS ADMINISTRATION STUDY OF HALOPERIDOL
- LARGE AMOUNT OF VITAMIN A HAS NO MAJOR EFFECTS ON THYROIDAL HORMONE SYNTHESIS IN TWO-STAGE RAT THYROID CARCINOGENESIS MODEL USING N-BIS(2-HYDROXYPROPYL)NITROSAMINE AND THIOUREA
- 21C-11-1 A study on mechanisms of the enhanced thyroidal tumorigenesis in rats by large amounts of vitamin A simultaneously given with thiourea : Effects on thyroidal hormone syntheses.
- 3A-19 A Mechanistic Study on Ovarian Carcinogenesis of Nitrofurazone in Mice
- 3A-16 Toxicological significance of the metabolite, 2,6-xylidine, in rats treated with a parent drug, xylazine
- 3A-06 Study on the Thyroid Tumor Promotion Effect of Kojic Acid
- 2A-04 Mechanistic study on testicular toxicity in rats caused by nitrofurazone
- CONFIRMATION STUDY, USING NITROBENZENE, OF THE COMBINED REPEAT DOSE AND REPRODUCTIVE/DEVELOPMENTAL TOXICITY TEST PROTOCOL PROPOSED BY THE ORGANIZATION FOR ECONOMIC COOPERATION AND DEVELOPMENT (OECD)
- COMRARISON OF TOXICITY OF p-DICHLOROBENZENE (p-DCB) GIVEN ORALLY AND BY INHALATION
- TOXICITY OF ORIENTAL BEZOAR AND ITS COMPONENTS
- Sebaceous Gland Metaplasia in a Mammary Fibroadenoma Developing in a Female Donryu Rat
- Uterine Adenocarcinoma in N-Ethyl-N'-nitro-N-nitrosoguanidine-treated Rats with High-dose Exposure to p-tert-Octylphenol during Adulthood
- O12-16 Effects of in utero and lactational exposure to low-doses of bisphenol A on the reproductive system in female rats
- 21WA-04-1 Effects on reproductive tract of male Donryu rats by neonatal exposure of p-tert octylphenol
- 21WA-03-5 Persistent effects on the reproductive tract in female rats by neonatal exposure of p-tert-octylphenol.
- High Yield Selective Induction of Uterine Endometrial Adenocarcinomas in CD-1 Mice by N-Ethyl-N'-nitro-N-nitrosoguanidine Combined with 17β-Estradiol
- Establishment of Two-stage Rat Uterine Carcinogenicity Model
- GENITAL TUMORS IN FEMALE RATS-INFLUENCE OF CHEMICALS AND/OR HORMONES AND HOST FACTORS ON THEIR OCCURRENCE
- ヒト曝露相当量を含むビスフェノールAの経胎盤・経授乳曝露はラットの雌性生殖器および子宮発がんに影響を与えない
- EFFECTS OF BARBITAL ON NEURO-ONCOGENESIS IN A TRANSPLACENTAL CARCINOGENICITY MODEL USING F344 RATS
- Reduction of Primordial Follicles Caused by Maternal Treatment with Busulfan Promotes Endometrial Adenocarcinoma Development in Donryu Rats
- Maternal Exposure to Low Doses of Bisphenol A Has No Effects on Development of Female Reproductive Tract and Uterine Carcinogenesis in Donryu Rats
- CHRONIC TOXICITY OF MICROENCAPSULATED BROMODICHLOROMETHANE ADMINISTERED IN THE DIET TO WISTAR RATS
- ELECTROKINETIC CHARGE OF TRANSPLANTABLE FRIEND VIRUS-INDUCED TUMORS IN RATS
- B08 CHRONIC TOXICITY STUDIES ON TBM, DBCM AND BDCM IN WISTAR RATS
- Twenty-Eight-Day Repeated-Dose Toxicity Studies for Detection of Weak Endocrine Disrupting Effects of Nonylphenol and Atrazine in Female Rats
- Modifying Effects of Endocrine Disrupting Chemicals on N-bis (2-hydroxypropyl) Nitrosamine and Sulfadimethoxine-Induced Thyroid Carcinogenesis in Rats
- Spontaneous Tumors in the Uterus, Testis and Other Organs of F_1 Hybrids between Donryu and F344 Rats
- Effects of Endocrine Disrupting Chemicals with Estrogenic Activity on the Female Reproductive System in Rats
- Involvements of Estrogen Receptor, Proliferating Cell Nuclear Antigen and p53 in Endometrial Adenocarcinoma Development in Donryu Rats
- A Spontaneous Rat Ovarian Cystoadenocarcinoma with Papillary Growth to the Serosa.
- Uterine Carcinogenesis by Chemicals/Hormones in Rodents.