EFFECTS OF BARBITAL ON NEURO-ONCOGENESIS IN A TRANSPLACENTAL CARCINOGENICITY MODEL USING F344 RATS
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概要
- 論文の詳細を見る
Effects of barbital (BB) on neuro-oncogenesis were examined in a rat transplacental carcinogenesis model. Pregnant F344 rats were divided into 7 groups. Dams in group I received subcutaneous injections of 10 mg/rat 1-butyl-1-nitrosourea (BNU) on the days 15, 18 and 21 of pregnancy and dams in groups II-IV, 1mg/rat BNU on the same time schcdule. In addition to the treatment with BNU, dams in group IV were given 0.125% BB solution as their drinking water from the day 12 of pregnancy to parturition. Offspring in groups III and IV received 0.125% BB solution as drinking water from 4 weeks of age until the termination of the study. Animals in groups V and VI were given 0.25% and 0.125% BB solutions, respectively, in the peri- and postnatal period without BNU treatment. Dams in group VII received 250 mg/kg BB sub-cutaneously on the days 15, 18 and 21 of pregnancy. Offspring in all groups were observed until 105-116 weeks of age. High yields of neurogenic tumors, such as gliomas and neurinomas, were observed in group I. In groups II, III and IV, single cases of a chordoma, a granular cell tumor, and a neurinoma and a malignant reticulosis, which are known to occur spontaneously, were noted, although no gliomas were found. No neurogenic tumors were observed in groups V-VII. With regard to lesions other than those in neurogenic organs, a significant increase in liver tumors was observed in group III compared to group II. In contrast, lung tumors were not found in group III, while they were observed in groups II and IV. These results suggest that BB has no neuro-carcinogenic activity in the rat transplacental carcinogenesis model.
- 日本トキシコロジー学会の論文
- 1995-02-25
著者
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Onodera Hiroshi
Pharmaceuticals And Medical Devices Agency
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MAEKAWA AKIHIKO
Department of Pathology, Sasaki Institute
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Maekawa A
Sasaki Inst. Tokyo
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Maekawa Akihiko
Department Of Pathology Nagoya City University Medical School
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Onodera H
Pharmaceuticals And Medical Devices Agency
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TANIGAWA Hiroyuki
Divison of Safety Assessment, Research Laboratories, Roussel Morishita Co., Ltd.
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ONODERA Hiroshi
Dvision of Pathology, Biological Safety Research Center, National Institute of Health Sciences
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Onodera Hiroshi
Dvision Of Pathology Biological Safety Research Center National Institute Of Health Sciences
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Tanigawa Hiroyuki
Divison Of Safety Assessment Research Laboratories Roussel Morishita Co. Ltd.
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