Concurrent Administration of Fish Meal and Sodium Nitrite Does not Promote Glandular Stomach Carcinogenesis in Rats after Treatment with N-methyl-N'-nitro-N-nitrosoguanidine

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概要

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• Post-initiation modifying effects of concurrent administration of fish meal and sodium nitrite on the development of glandular stomach tumors after treatment with N-methyl-N-nitro-N-nitrosoguanidine (MNNG) were investigated in a total of 120 male 6-week-old Wistar rats, divided into 6 groups. Groups 1-3 (30 animals each) were given 100 ppm MNNG in their drinking water and 10% NaCl in diet for 8 weeks as an initiation treatment for gastric cancer induction and thereafter respectively fed diets containing 64%, 32%, and 8% (original concentration in the basal diet) fish meal, and simultaneously given 0.12% sodium nitrite in the drinking water for 52 weeks. Groups 4-6 (10 animals each) were similarly treated without the application of MNNG and NaCl. At the end of the 60th experimental week, all surviving animals were autopsied and examined histopathologically for the existence of gastric proliferative lesions. The incidences and multiplicity of atypical hyperplasias or adenocarcinomas were comparable among groups 1-3. No gastric proliferative lesions were found in groups 4-6. Interestingly, the incidence of adenocarcinomas of the small intestine was significantly (p<0.05) decreased in groups 1 and 2, and that of intrahepatic cholangiomas was significantly (p<0.05) increased in group 1 as compared to the group 3 values. Our results suggest that concurrent administration of fish meal and sodium nitrite does not affect the post-initiation phase of MNNG-initiated glandular stomach carcinogenesis in the rat, but rather modulates development of proliferative lesions in other organs such as the small intestine and liver.

• 日本毒性病理学会の論文
• 1999-06-01

著者

• Hirose Masao

  Division of Pathology, National Institute of Health Sciences

• Nishikawa Akiyoshi

  Division of Pathology, National Institute of Health Sciences

• FURUKAWA Fumio

  Division of Pathology, National Institute of Health Sciences

• MIYAUCHI Makoto

  Division of Pathology, National Institute of Health Sciences

• SON Hwa-young

  Division of Pathology, National Institute of Health Sciences

• Nakamura H

  Department Of Analytical Chemistry Hoshi University

• Furukawa F

  Division Of Pathology National Institute Of Health Sciences

• Furukawa Fumio

  国立衛生試験所

• Furukawa Fumio

  Division Of Pathology National Institute Of Health Sciences

• NAKAMURA Hideaki

  Division of Pathology, National Institute of Health Sciences

• Hirose Masao

  Division Of Pathology National Institute Of Health Sciences

• Son Hwa-young

  Division Of Pathology National Institute Of Health Sciences

• Nakamura Hideaki

  Central Laboratory And Radiation Biology Aichi Cancer Center Research Institute

• Nishikawa Akiyoshi

  Division Of Pathology Biology Safety Research Center National Institute Of Health Sciences

• Miyauchi M

  Division Of Pathology National Institute Of Health Sciences

• Nakamura Hideaki

  Department Of Analytical Chemistry Hoshi University

• Nakamura Hideaki

  Central Laboratory And Radiation Biology Aichi Cancer Center Research Institute Kanokoden

• Miyauchi Makoto

  Division Of Pathology National Institute Of Health Sciences

• Nakamura Hajime

  Gastroenterological Surgery Nagoya University Graduate School Of Medicine

• Nakamura Hideaki

  Department of Analytical Chemistry, Hoshi University

• NAKAMURA Hideaki

  Department of Physics, Kumamoto University

• Nakamura Hideaki

  Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Medicine), Graduate School of Medicine, University of the Ryukyus, Japan

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